GREB1 and HMMR

Number of citations: 0 (PubMedID 25640309)
Data Source: BioGRID (two hybrid)

		GREB1	HMMR
Name		growth regulating estrogen receptor binding 1	hyaluronan mediated motility receptor
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Membrane Extracellular Exosome	Cytoplasm Centrosome Spindle Cytosol Cytoskeleton Plasma Membrane Cell Surface Microtubule Cytoskeleton Membrane
	Molecular Function	None	Protein Binding Hyaluronic Acid Binding Cargo Receptor Activity
	Biological Process	Morphogenesis Of An Epithelium	Receptor-mediated Endocytosis Hyaluronan Catabolic Process
Pathways		Estrogen-dependent gene expression	Hyaluronan metabolism Hyaluronan degradation AURKA Activation by TPX2
Drugs		None	Hyaluronic acid
GWAS		Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653 ) Diisocyanate-induced asthma ( 25918132 ) Endometriosis ( 23104006 28537267 ) Gynecologic disease (multivariate analysis) ( 31488892 ) High density lipoprotein cholesterol levels ( 30108155 ) Inferior parietal cortex volume ( 31530798 ) LDL cholesterol levels in HIV infection ( 33109212 ) Obesity-related traits ( 23251661 ) Severe insulin-resistant type 2 diabetes ( 34737425 ) Uterine fibroids ( 30194396 31649266 )	Metabolite levels ( 23823483 )
Interacting Genes		12 interacting genes: BCAR3 CASP8 CDKN2C ESR1 HMMR HRAS LSP1 PALB2 RB1CC1 SMAD4 TGFB1 XRCC3	18 interacting genes: ACTB BACH1 CALM1 CD44 CDH13 CEBPA CFTR GREB1 IL24 ITIH5 MAPK3 MORN4 NAT2 SVIL THRSP TPX2 TRIM54 TUBB2A
Entrez ID		9687	3161
HPRD ID		13611	02963
Ensembl ID		ENSG00000196208	ENSG00000072571
Uniprot IDs		Q4ZG55	O75330
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Regulation Of MiRNA Metabolic Process Extrinsic Apoptotic Signaling Pathway Apoptotic Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Cell Population Proliferation Positive Regulation Of Fibroblast Proliferation Regulation Of Intracellular Signal Transduction Positive Regulation Of MiRNA Metabolic Process Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Regulation Of MiRNA Transcription Positive Regulation Of Extracellular Matrix Assembly Positive Regulation Of Signal Transduction Branch Elongation Of An Epithelium Regulation Of Fibroblast Proliferation Hyaluronan Catabolic Process Regulation Of Cell Population Proliferation Positive Regulation Of Macrophage Differentiation Regulation Of MAPK Cascade Response To Estradiol Positive Regulation Of Cell Communication Positive Regulation Of Signaling Axis Elongation Branching Involved In Mammary Gland Duct Morphogenesis Regulation Of Cardiac Muscle Cell Differentiation Negative Regulation Of Cell Population Proliferation Developmental Growth Branching Morphogenesis Of An Epithelial Tube Uterus Development Glycosaminoglycan Catabolic Process Regulation Of Extracellular Matrix Assembly Hyaluronan Metabolic Process Regulation Of Macrophage Differentiation Morphogenesis Of A Branching Epithelium Negative Regulation Of MiRNA Transcription Positive Regulation Of Extracellular Matrix Organization Animal Organ Development Morphogenesis Of A Branching Structure Negative Regulation Of Cell Growth Positive Regulation Of MAPK Cascade Apoptotic Process Anatomical Structure Morphogenesis Negative Regulation Of Programmed Cell Death Regulation Of Signal Transduction Endoderm Development Positive Regulation Of Cell Population Proliferation Protein-membrane Adaptor Activity Programmed Cell Death Cell Death Response To Stress	Focal Adhesion Negative Regulation Of Protein-containing Complex Disassembly Regulation Of Protein Depolymerization Calyx Of Held