GREB1 and XRCC3

Number of citations of the paper that reports this interaction (PubMedID 25640309)
0

Data Source:
BioGRID (two hybrid)

		GREB1	XRCC3
Description		growth regulating estrogen receptor binding 1	X-ray repair cross complementing 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Membrane Extracellular Exosome	Chromosome, Telomeric Region Nucleus Nucleoplasm Replication Fork Cytoplasm Mitochondrion Cytosol Rad51C-XRCC3 Complex Perinuclear Region Of Cytoplasm
	Molecular Function		Nucleotide Binding Four-way Junction DNA Binding DNA Binding Protein Binding ATP Binding Crossover Junction DNA Endonuclease Activity ATP-dependent DNA Damage Sensor Activity
	Biological Process	Morphogenesis Of An Epithelium	Telomere Maintenance Via Recombination Double-strand Break Repair Via Homologous Recombination DNA Repair DNA Recombination DNA Damage Response Regulation Of Centrosome Duplication Interstrand Cross-link Repair Double-strand Break Repair Via Synthesis-dependent Strand Annealing Resolution Of Mitotic Recombination Intermediates Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint T-circle Formation Telomeric Loop Disassembly Telomere Maintenance Via Telomere Trimming
Pathways		Estrogen-dependent gene expression	HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange
Drugs
Diseases
GWAS		Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Diisocyanate-induced asthma ( 25918132) Endometriosis ( 23104006 28537267) Gynecologic disease (multivariate analysis) ( 31488892) High density lipoprotein cholesterol levels ( 30108155) Inferior parietal cortex volume ( 31530798) LDL cholesterol levels in HIV infection ( 33109212) Obesity-related traits ( 23251661) Severe insulin-resistant type 2 diabetes ( 34737425) Uterine fibroids ( 30194396 31649266)	Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 31043756) Body mass index ( 26426971 29273807) Schizophrenia ( 25056061 29483656)
Interacting Genes		12 interacting genes: BCAR3 CASP8 CDKN2C ESR1 HMMR HRAS LSP1 PALB2 RB1CC1 SMAD4 TGFB1 XRCC3	22 interacting genes: BAP1 BCAS3 CXCL1 FANCG GREB1 ITIH5 LRATD2 MRC2 OSGIN1 PALB2 PSMC3IP RAD51 RAD51C RAD51D RNF20 SCGB3A1 SERPINB5 SNAI1 SWSAP1 TFF1 ZNHIT3 ZSWIM7
Entrez ID		9687	7517
HPRD ID		13611	07201
Ensembl ID		ENSG00000196208	ENSG00000126215
Uniprot IDs		Q4ZG55	O43542 Q53XC8
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of MiRNA Metabolic Process Extrinsic Apoptotic Signaling Pathway Apoptotic Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Cell Population Proliferation Positive Regulation Of Fibroblast Proliferation Regulation Of Intracellular Signal Transduction Positive Regulation Of MiRNA Metabolic Process Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Regulation Of MiRNA Transcription Positive Regulation Of Extracellular Matrix Assembly Positive Regulation Of Signal Transduction Branch Elongation Of An Epithelium Regulation Of Fibroblast Proliferation Hyaluronan Catabolic Process Regulation Of Cell Population Proliferation Positive Regulation Of Macrophage Differentiation Regulation Of MAPK Cascade Response To Estradiol Positive Regulation Of Cell Communication Positive Regulation Of Signaling Axis Elongation Branching Involved In Mammary Gland Duct Morphogenesis Regulation Of Cardiac Muscle Cell Differentiation Negative Regulation Of Cell Population Proliferation Developmental Growth Branching Morphogenesis Of An Epithelial Tube Uterus Development Glycosaminoglycan Catabolic Process Regulation Of Extracellular Matrix Assembly Hyaluronan Metabolic Process Regulation Of Macrophage Differentiation Morphogenesis Of A Branching Epithelium Negative Regulation Of MiRNA Transcription Positive Regulation Of Extracellular Matrix Organization Animal Organ Development Morphogenesis Of A Branching Structure Negative Regulation Of Cell Growth Positive Regulation Of MAPK Cascade Apoptotic Process Anatomical Structure Morphogenesis Negative Regulation Of Programmed Cell Death Regulation Of Signal Transduction Endoderm Development Positive Regulation Of Cell Population Proliferation Protein-membrane Adaptor Activity Programmed Cell Death Cell Death Response To Stress	Recombinational Repair DNA Strand Invasion Double-strand Break Repair Via Homologous Recombination DNA Recombination Reciprocal Meiotic Recombination Homologous Recombination Double-strand Break Repair Telomere Maintenance Via Recombination ATP-dependent DNA Damage Sensor Activity Shu Complex Mitotic Recombination DNA Metabolic Process DNA Repair Rad51B-Rad51C-Rad51D-XRCC2 Complex DNA Recombinase Assembly Interstrand Cross-link Repair DNA Damage Response Meiosis I Cell Cycle Process Four-way Junction DNA Binding Telomere Maintenance Single-stranded DNA Binding Nucleic Acid Metabolic Process Telomere Organization Replication Fork ATP-dependent Activity, Acting On DNA Reproductive Process Growth Factor Activity Response To Glucoside Chromosome Organization Meiosis I Female Meiosis Sister Chromatid Cohesion Nucleate Erythrocyte Differentiation Thrombocyte Differentiation Meiotic Joint Molecule Formation DNA Recombinase Auxiliary Factor Complex Recombinase Activator Activity Meiotic Strand Invasion Involved In Reciprocal Meiotic Recombination Histone H2B C-terminal K Residue Ubiquitin Ligase Activity Condensed Nuclear Chromosome Mitotic Recombination-dependent Replication Fork Processing DNA Strand Exchange Activity Chromosome Organization Involved In Meiotic Cell Cycle Presynaptic Intermediate Filament Cytoskeleton Rad51C-XRCC3 Complex Meiotic DNA Recombinase Assembly Mesoderm Development Negative Regulation Of Cell Differentiation Involved In Embryonic Placenta Development Macrophage Homeostasis Cellular Response To Stress Nucleobase-containing Compound Metabolic Process
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