GREB1 and BCAR3

Number of citations of the paper that reports this interaction (PubMedID 25640309)
0

Data Source:
BioGRID (two hybrid)

		GREB1	BCAR3
Description		growth regulating estrogen receptor binding 1	BCAR3 adaptor protein, NSP family member
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Membrane Extracellular Exosome	Cytoplasm Focal Adhesion Membrane Anchoring Junction
	Molecular Function		Phosphotyrosine Residue Binding Guanyl-nucleotide Exchange Factor Activity Protein Binding Kinase Binding
	Biological Process	Morphogenesis Of An Epithelium	Lens Morphogenesis In Camera-type Eye Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Small GTPase-mediated Signal Transduction Positive Regulation Of Cell Population Proliferation Insulin Receptor Signaling Pathway Response To Xenobiotic Stimulus Positive Regulation Of MAPK Cascade Positive Regulation Of GTPase Activity Endothelin Receptor Signaling Pathway
Pathways		Estrogen-dependent gene expression
Drugs
Diseases
GWAS		Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Diisocyanate-induced asthma ( 25918132) Endometriosis ( 23104006 28537267) Gynecologic disease (multivariate analysis) ( 31488892) High density lipoprotein cholesterol levels ( 30108155) Inferior parietal cortex volume ( 31530798) LDL cholesterol levels in HIV infection ( 33109212) Obesity-related traits ( 23251661) Severe insulin-resistant type 2 diabetes ( 34737425) Uterine fibroids ( 30194396 31649266)	Alzheimer's disease progression score ( 29860282) Blood urea nitrogen levels ( 31152163) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Estimated glomerular filtration rate ( 31152163) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Liver fibrosis (total hepatic collagen content) ( 32953199) Major depressive disorder ( 27777418) Systolic blood pressure ( 30224653)
Interacting Genes		12 interacting genes: BCAR3 CASP8 CDKN2C ESR1 HMMR HRAS LSP1 PALB2 RB1CC1 SMAD4 TGFB1 XRCC3	38 interacting genes: AGR3 AP1M1 APP ATAD2 BAP1 BEX1 BEX2 CASZ1 CCDC57 CCL5 CST6 DKK3 DRC4 EGFR EPSTI1 ERBB2 ERBB3 ERBB4 ERRFI1 GAB1 GLCE GREB1 HOXC6 KIT KPNA1 MET MTA3 NEDD9 NSD3 OSGIN1 PDLIM2 PRDM14 PSMC3IP RPRD1A SERPINB5 THRSP UBASH3A VPS45
Entrez ID		9687	8412
HPRD ID		13611	05268
Ensembl ID		ENSG00000196208	ENSG00000137936
Uniprot IDs		Q4ZG55	A0A384MTS3 B3KNL6 B3KP06 O75815
PDB IDs			3T6A
Enriched GO Terms of Interacting Partners?		Regulation Of MiRNA Metabolic Process Extrinsic Apoptotic Signaling Pathway Apoptotic Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Cell Population Proliferation Positive Regulation Of Fibroblast Proliferation Regulation Of Intracellular Signal Transduction Positive Regulation Of MiRNA Metabolic Process Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Regulation Of MiRNA Transcription Positive Regulation Of Extracellular Matrix Assembly Positive Regulation Of Signal Transduction Branch Elongation Of An Epithelium Regulation Of Fibroblast Proliferation Hyaluronan Catabolic Process Regulation Of Cell Population Proliferation Positive Regulation Of Macrophage Differentiation Regulation Of MAPK Cascade Response To Estradiol Positive Regulation Of Cell Communication Positive Regulation Of Signaling Axis Elongation Branching Involved In Mammary Gland Duct Morphogenesis Regulation Of Cardiac Muscle Cell Differentiation Negative Regulation Of Cell Population Proliferation Developmental Growth Branching Morphogenesis Of An Epithelial Tube Uterus Development Glycosaminoglycan Catabolic Process Regulation Of Extracellular Matrix Assembly Hyaluronan Metabolic Process Regulation Of Macrophage Differentiation Morphogenesis Of A Branching Epithelium Negative Regulation Of MiRNA Transcription Positive Regulation Of Extracellular Matrix Organization Animal Organ Development Morphogenesis Of A Branching Structure Negative Regulation Of Cell Growth Positive Regulation Of MAPK Cascade Apoptotic Process Anatomical Structure Morphogenesis Negative Regulation Of Programmed Cell Death Regulation Of Signal Transduction Endoderm Development Positive Regulation Of Cell Population Proliferation Protein-membrane Adaptor Activity Programmed Cell Death Cell Death Response To Stress	Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Activity ERBB2 Signaling Pathway Receptor Complex Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Basal Plasma Membrane Protein Tyrosine Kinase Activity Regulation Of Peptidyl-tyrosine Phosphorylation Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Epithelial Cell Proliferation Cellular Response To Epidermal Growth Factor Stimulus Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Epithelial Cell Proliferation ERBB3:ERBB2 Complex Response To Epidermal Growth Factor Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Epidermal Growth Factor Receptor Activity Neuregulin Receptor Activity Regulation Of Cell Population Proliferation Cellular Response To Growth Factor Stimulus Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Epithelial Cell Proliferation Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction ErbB-3 Class Receptor Binding ERBB2-ERBB4 Signaling Pathway Molecular Function Inhibitor Activity Positive Regulation Of Phosphate Metabolic Process Response To Growth Factor Regulation Of Protein Modification Process Protein Kinase Activity Positive Regulation Of Lymphocyte Migration Positive Chemotaxis ERBB2-EGFR Signaling Pathway Growth Factor Binding Regulation Of Primary Metabolic Process Cell Population Proliferation Positive Regulation Of Protein Phosphorylation Positive Regulation Of Receptor Signaling Pathway Via STAT ERBB2-ERBB3 Signaling Pathway ERBB3 Signaling Pathway ERBB4 Signaling Pathway Positive Regulation Of Mitotic Cell Cycle Regulation Of Protein Phosphorylation Basolateral Plasma Membrane Positive Regulation Of Cell Migration Anatomical Structure Morphogenesis Cell Surface Receptor Signaling Pathway
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