INO80 and ACTN4

Number of citations of the paper that reports this interaction (PMID 20197409)
10

Data Source:
BioGRID (affinity chromatography technology, pull down)

		INO80	ACTN4
Gene Name		INO80 complex subunit	actinin, alpha 4
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Microtubule Ino80 Complex	Stress Fiber Extracellular Region Extracellular Space Nucleus Cytoplasm Cell-cell Junction Focal Adhesion Z Disc Ribonucleoprotein Complex Cortical Cytoskeleton Platelet Alpha Granule Lumen Pseudopodium Neuron Projection Protein Complex Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	DNA Binding DNA Helicase Activity Actin Binding Protein Binding ATP Binding ATPase Activity Alpha-tubulin Binding	Nucleoside Binding Actin Binding Integrin Binding Calcium Ion Binding Protein Binding Ligand-dependent Nuclear Receptor Transcription Coactivator Activity Nuclear Hormone Receptor Binding Protein Homodimerization Activity Retinoic Acid Receptor Binding Poly(A) RNA Binding Protein N-terminus Binding Actin Filament Binding
	Biological Process	Mitotic Sister Chromatid Segregation Double-strand Break Repair Via Homologous Recombination Double-strand Break Repair Chromatin Remodeling Positive Regulation Of Nuclear Cell Cycle DNA Replication Positive Regulation Of Cell Growth DNA Duplex Unwinding Cellular Response To UV Positive Regulation Of Transcription From RNA Polymerase II Promoter Spindle Assembly Cell Division UV-damage Excision Repair Cellular Response To Ionizing Radiation Regulation Of G1/S Transition Of Mitotic Cell Cycle	Response To Hypoxia Platelet Degranulation Blood Coagulation Protein Transport Platelet Activation Positive Regulation Of Sodium:proton Antiporter Activity Peroxisome Proliferator Activated Receptor Signaling Pathway Regulation Of Apoptotic Process Retinoic Acid Receptor Signaling Pathway Positive Regulation Of Pinocytosis Actin Filament Bundle Assembly Negative Regulation Of Cellular Component Movement Positive Regulation Of Cellular Component Movement Tight Junction Assembly Protein Localization To Tight Junction Regulation Of Nucleic Acid-templated Transcription
Pathways			Response to elevated platelet cytosolic Ca2+ Nephrin interactions Platelet degranulation Platelet activation, signaling and aggregation
Drugs
Diseases
GWAS			Heart rate ( 23583979)
Protein-Protein Interactions		2 interactors: ACTN4 YY1	43 interactors: ACTC1 ACTN3 ADORA2A ATP6V1B1 ATXN7 BMP7 CAMK2A CAMK2B CAMK2G CDKN2A COIL COL17A1 ESR1 GSN HDAC7 INO80 ITGB1 KPNA2 LRRC7 MAGI1 MAPK7 MEF2A MYOZ1 MYOZ2 NEB NOS2 NOS3 PDLIM1 POT1 PTPN11 PTPN6 RPS27 SACS SERPINE1 SLC2A4 SLC9A3R2 STAT1 TJP1 TRIM3 TXN UCHL5 USP6NL VDR
Entrez ID		54617	81
HPRD ID		10024	05222
Ensembl ID		ENSG00000128908
Uniprot IDs		Q9ULG1	O43707
PDB IDs			1WLX 1YDI 2R0O
Enriched GO Terms of Interacting Partners?		Response To Prostaglandin F Protein Localization To Tight Junction Positive Regulation Of Pinocytosis Positive Regulation Of Sodium:proton Antiporter Activity Regulation Of Sodium:proton Antiporter Activity Peroxisome Proliferator Activated Receptor Signaling Pathway Protein Localization To Cell Junction Response To UV-C Positive Regulation Of Sodium Ion Transmembrane Transporter Activity Regulation Of Proton Transport Positive Regulation Of Sodium Ion Transmembrane Transport Actin Crosslink Formation Response To Abiotic Stimulus Retinoic Acid Receptor Signaling Pathway Regulation Of Sodium Ion Transmembrane Transporter Activity Regulation Of Sodium Ion Transmembrane Transport Positive Regulation Of Sodium Ion Transport Tight Junction Assembly Positive Regulation Of Ion Transmembrane Transporter Activity Positive Regulation Of Transporter Activity Cellular Response To UV Regulation Of Sodium Ion Transport Actin Filament Bundle Assembly Response To Fatty Acid Platelet Degranulation Apical Junction Assembly Positive Regulation Of Ion Transmembrane Transport Double-strand Break Repair Via Homologous Recombination Recombinational Repair Cellular Response To Light Stimulus Positive Regulation Of Endocytosis	Cellular Response To Organic Substance Response To Organic Substance Negative Regulation Of Signaling Response To Stress Developmental Process Cellular Response To Interferon-gamma Response To Interferon-gamma Negative Regulation Of Signal Transduction Regulation Of Cell Death Response To Abiotic Stimulus Defense Response Cellular Response To Lipid Regulation Of Signaling Regulation Of Apoptotic Process Signal Transduction Interferon-gamma-mediated Signaling Pathway Anatomical Structure Development Negative Regulation Of Cellular Metabolic Process Regulation Of Signal Transduction Cell Surface Receptor Signaling Pathway Positive Regulation Of Cellular Biosynthetic Process Enzyme Linked Receptor Protein Signaling Pathway Cellular Component Assembly Signaling Cellular Response To Stimulus Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Intracellular Signal Transduction Cellular Response To Hormone Stimulus Cell Communication Regulation Of Phosphorus Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Innate Immune Response Regulation Of Catalytic Activity Anatomical Structure Morphogenesis Response To Lipid Multicellular Organismal Development Response To Stimulus Regulation Of Cellular Component Organization Regulation Of Cellular Process Response To Hormone Abortive Mitotic Cell Cycle System Development Mitotic Cell Cycle Cell Differentiation Positive Regulation Of Metabolic Process Regulation Of Body Fluid Levels Cellular Response To Cytokine Stimulus G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Lipopolysaccharide
Tagcloud ?		batf ccnd2 coexpressed cooccupancy ctcf ebf ebna2 ebnalp enhancers ets1 h2az h3k27ac h3k9ac irf4 looping lp lymphoblastoid med ncor pax5 rad21 rbpj removes rnapii smc3 tblr tfs yy1 znf143	1beta actin actinin blocks coactivator cytosol defective fails filtration focal fsgs glomerular glomerulosclerosis ikappabalpha k255e mechanistically nphs1 p50 p65 podocytes potentiate proteinuria recruit reporter segmental specialized terminally tnfalpha translocate
Tagcloud (Difference) ?		batf ccnd2 coexpressed cooccupancy ctcf ebf ebna2 ebnalp enhancers ets1 h2az h3k27ac h3k9ac irf4 looping lp lymphoblastoid med ncor pax5 rad21 rbpj removes rnapii smc3 tblr tfs yy1 znf143	1beta actin actinin blocks coactivator cytosol defective fails filtration focal fsgs glomerular glomerulosclerosis ikappabalpha k255e mechanistically nphs1 p50 p65 podocytes potentiate proteinuria recruit reporter segmental specialized terminally tnfalpha translocate
Tagcloud (Intersection) ?