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AIMP2 and PPP2R1A
Number of citations of the paper that reports this interaction (PubMedID
21900206
)
0
Data Source:
BioGRID
(two hybrid)
AIMP2
PPP2R1A
Description
aminoacyl tRNA synthetase complex interacting multifunctional protein 2
protein phosphatase 2 scaffold subunit Aalpha
Image
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Cytosol
Membrane
Aminoacyl-tRNA Synthetase Multienzyme Complex
Protein Phosphatase Type 2A Complex
Chromosome, Centromeric Region
Chromatin
Nucleus
Chromosome
Cytoplasm
Mitochondrion
Cytosol
Plasma Membrane
Microtubule Cytoskeleton
Membrane
Lateral Plasma Membrane
Dendrite
Cell Projection
Neuron Projection
Neuronal Cell Body
Synapse
Extracellular Exosome
FAR/SIN/STRIPAK Complex
Glutamatergic Synapse
INTAC Complex
Molecular Function
Protein Binding
Protein-macromolecule Adaptor Activity
Molecular Adaptor Activity
Protein Serine/threonine Phosphatase Activity
Protein Binding
Protein Phosphatase Regulator Activity
Protein Heterodimerization Activity
Protein Antigen Binding
Biological Process
Translation
Apoptotic Process
Negative Regulation Of Cell Population Proliferation
Protein Ubiquitination
Cell Differentiation
Positive Regulation Of Protein Ubiquitination
Positive Regulation Of Neuron Apoptotic Process
Type II Pneumocyte Differentiation
Protein-containing Complex Assembly
Transcription By RNA Polymerase II
Transcription Elongation By RNA Polymerase II
Chromosome Segregation
Female Meiotic Nuclear Division
Negative Regulation Of Hippo Signaling
Intracellular Signal Transduction
Regulation Of Growth
T Cell Homeostasis
Regulation Of Cell Differentiation
Spindle Assembly
Meiotic Spindle Elongation
Mitotic Sister Chromatid Separation
Meiotic Sister Chromatid Cohesion, Centromeric
Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Protein-containing Complex Assembly
RNA Polymerase II Transcription Initiation Surveillance
Regulation Of Meiotic Cell Cycle Process Involved In Oocyte Maturation
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways
Selenoamino acid metabolism
Cytosolic tRNA aminoacylation
Transcriptional and post-translational regulation of MITF-M expression and activity
Inhibition of replication initiation of damaged DNA by RB1/E2F1
Spry regulation of FGF signaling
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
PP2A-mediated dephosphorylation of key metabolic factors
DARPP-32 events
Degradation of beta-catenin by the destruction complex
Beta-catenin phosphorylation cascade
ERK/MAPK targets
ERKs are inactivated
MASTL Facilitates Mitotic Progression
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
Regulation of PLK1 Activity at G2/M Transition
Initiation of Nuclear Envelope (NE) Reformation
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization from the centrosome
Recruitment of NuMA to mitotic centrosomes
Co-stimulation by CD28
Co-inhibition by CTLA4
Platelet sensitization by LDL
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Signaling by GSK3beta mutants
CTNNB1 S33 mutants aren't phosphorylated
CTNNB1 S37 mutants aren't phosphorylated
CTNNB1 S45 mutants aren't phosphorylated
CTNNB1 T41 mutants aren't phosphorylated
APC truncation mutants have impaired AXIN binding
AXIN missense mutants destabilize the destruction complex
Truncations of AMER1 destabilize the destruction complex
Anchoring of the basal body to the plasma membrane
RHO GTPases Activate Formins
RAF activation
Negative regulation of MAPK pathway
Regulation of TP53 Degradation
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Mitotic Prometaphase
Cyclin D associated events in G1
Cyclin A/B1/B2 associated events during G2/M transition
AURKA Activation by TPX2
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism
EML4 and NUDC in mitotic spindle formation
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
PKR-mediated signaling
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells
Drugs
2,6,8-Trimethyl-3-Amino-9-Benzyl-9-Methoxynonanoic Acid
(2S,3S,4E,6E,8S,9S)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyldeca-4,6-dienoic acid
Diseases
GWAS
High light scatter reticulocyte count (
32888494
)
High light scatter reticulocyte percentage of red cells (
32888494
)
Reticulocyte count (
32888494
)
Reticulocyte fraction of red cells (
27863252
32888494
)
Interacting Genes
103 interacting genes:
AIMP1
APP
BCAS2
BEX3
BLOC1S4
BRME1
BYSL
C1orf216
CBY2
CEBPA
CEP126
CHD3
DARS1
DARS2
DEAF1
DISC1
DRC12
DSN1
EPRS1
EPS8
EXOC8
FGB
FHL3
FILNC1
FUBP1
GYS1
ICE1
KARS1
KDR
KLC2
KRT31
KRT33B
KRT34
KRT36
LMO2
LMO3
LNX1
LUC7L2
MATR3
MCF2L
MIR106A
MIR107
MIR122
MIR128-1
MIR128-2
MIR138-2
MIR15A
MIR18A
MIR199A1
MIR19A
MIR19B1
MIR19B2
MIR200C
MIR205
MIR20A
MIR20B
MIR21
MIR214
MIR221
MIR222
MIR25
MIR29A
MIR34A
MIR34B
MIR34C
MIR429
MIR451A
MIR7-1
MIR7-2
MIR92A2
MIRLET7A1
MIRLET7A2
MIRLET7A3
MIRLET7B
MIRLET7C
MIRLET7E
MIRLET7F1
MIRLET7F2
MIRLET7I
MIS18A
NDEL1
NECAB2
NTAQ1
PFDN6
PLEKHF2
PPP2R1A
PRKAA2
PRKN
PSME1
RABEP1
SBK3
SLU7
SMURF2
SPATA18
TANK
TCP11
TERF2IP
TEX12
TFIP11
TRAF2
TRMT2A
ZC3H12A
ZGPAT
59 interacting genes:
AIMP2
AKT1
AMOTL2
ARIH2
ATM
CARD11
CARHSP1
CDC42
CDK1
CSDC2
CSNK2B
DAPK1
DELEC1
DUX4
EEF2
ESR1
FBXO43
GNA12
GOLGA6A
GOLGA8F
GRIN1
GRIN2D
HSF2
HSPD1
IPO9
LINC01554
MAP3K7
MAPK6
MCM3
OGT
PARK7
PLAAT3
PPP2CA
PPP2R2A
PPP2R3B
PPP2R5A
PPP2R5B
PPP4C
PPP5C
PRDX1
PRDX2
PTPA
RAB11A
RAB18
RAB7A
RAP1A
RORC
SGO1
SGO2
SLC25A21-AS1
SLC6A2
SMAD2
SMAD3
STRN
STRN3
SUMO2
TAB1
TRADD
ZFYVE9
Entrez ID
7965
5518
HPRD ID
02915
16184
Ensembl ID
ENSG00000106305
ENSG00000105568
Uniprot IDs
A8MU58
Q13155
A8K7B7
B3KQV6
P30153
PDB IDs
4DPG
4YCU
4YCW
5A1N
5A34
5A5H
5Y6L
6ILD
6IY6
6JPV
6K39
8J9S
9DPL
1B3U
2IE3
2IE4
2NPP
2NYL
2NYM
2PKG
3C5W
3DW8
3K7V
3K7W
4I5L
4I5N
4LAC
5W0W
6IUR
6NTS
7CUN
7K36
7PKS
7SOY
7YCX
8RBX
8RBZ
8RC4
8SO0
8TTB
8TWE
8TWI
8U1X
8U89
8UWB
8YJB
Enriched GO Terms of Interacting Partners
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MiRNA-mediated Post-transcriptional Gene Silencing
Regulatory NcRNA-mediated Post-transcriptional Gene Silencing
Post-transcriptional Gene Silencing
RISC Complex
Regulatory NcRNA-mediated Gene Silencing
MRNA Base-pairing Post-transcriptional Repressor Activity
Post-transcriptional Regulation Of Gene Expression
Extracellular Vesicle
Negative Regulation Of Gene Expression
MiRNA-mediated Gene Silencing By MRNA Destabilization
MRNA 3'-UTR Binding
MiRNA-mediated Gene Silencing By Inhibition Of Translation
Negative Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Metabolic Process
Negative Regulation Of Biosynthetic Process
MRNA Destabilization
RNA Destabilization
Positive Regulation Of MRNA Catabolic Process
Negative Regulation Of Vascular Endothelial Growth Factor Production
Positive Regulation Of MRNA Metabolic Process
Negative Regulation Of Translation
Regulation Of MRNA Stability
Regulation Of Angiogenesis
Negative Regulation Of Angiogenesis
Negative Regulation Of Vasculature Development
Regulation Of Vasculature Development
Regulation Of RNA Stability
Negative Regulation Of Cytokine Production
Negative Regulation Of Signal Transduction
Regulation Of Cell Migration Involved In Sprouting Angiogenesis
Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis
Negative Regulation Of Signaling
Negative Regulation Of Cell Communication
Negative Regulation Of Protein Metabolic Process
Regulation Of Endothelial Cell Migration
Negative Regulation Of Endothelial Cell Migration
Positive Regulation Of Catabolic Process
Negative Regulation Of Blood Vessel Endothelial Cell Migration
Positive Regulation Of Cardiac Muscle Hypertrophy
Negative Regulation Of Sprouting Angiogenesis
Extracellular Space
Regulation Of Macromolecule Metabolic Process
Regulation Of Blood Vessel Endothelial Cell Migration
Regulation Of MRNA Metabolic Process
Negative Regulation Of Cell Migration
Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Multicellular Organismal Process
Negative Regulation Of Cellular Response To Growth Factor Stimulus
Negative Regulation Of Cell Motility
Protein Phosphatase Type 2A Complex
Intracellular Signal Transduction
Intracellular Signaling Cassette
Cytosol
Protein Phosphatase 2A Binding
Cytoplasm
Protein Phosphatase Regulator Activity
Signal Transduction
Peroxiredoxin Activity
Cellular Response To Oxygen-containing Compound
Canonical NF-kappaB Signal Transduction
Regulation Of Signal Transduction
Glutamatergic Synapse
Response To Oxidative Stress
G Protein Activity
Positive Regulation Of Signal Transduction
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Protein-containing Complex
Regulation Of Cell Communication
Regulation Of Signaling
Response To Growth Factor
Cellular Response To Nerve Growth Factor Stimulus
Tau Protein Binding
Response To Nerve Growth Factor
Removal Of Superoxide Radicals
Response To Reactive Oxygen Species
Positive Regulation Of Cell Communication
Regulation Of Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Signaling
Kinase Binding
Positive Regulation Of Intracellular Signal Transduction
Cell Population Proliferation
Regulation Of Programmed Cell Death
Negative Regulation Of Hydrogen Peroxide-induced Neuron Intrinsic Apoptotic Signaling Pathway
Regulation Of Intracellular Signal Transduction
Protein-containing Complex Binding
GTP Binding
Protein Phosphatase Activator Activity
Phosphatase Binding
Paraxial Mesoderm Morphogenesis
Transforming Growth Factor Beta Receptor Signaling Pathway
FAR/SIN/STRIPAK Complex
Regulation Of Protein Catabolic Process
Cellular Response To Growth Factor Stimulus
Peptidyl-threonine Phosphorylation
Calmodulin Binding
Protein Metabolic Process
Positive Regulation Of Cellular Component Biogenesis
Regulation Of Proteasomal Protein Catabolic Process
Regulation Of Cellular Localization
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Tagcloud (Intersection)
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