AIMP2 and MCF2L

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		AIMP2	MCF2L
Gene Name		aminoacyl tRNA synthetase complex-interacting multifunctional protein 2	MCF.2 cell line derived transforming sequence-like
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytosol Membrane	Extracellular Space Cytosol Plasma Membrane Lamellipodium
	Molecular Function	Protein Binding	Rho Guanyl-nucleotide Exchange Factor Activity 1-phosphatidylinositol Binding
	Biological Process	TRNA Aminoacylation For Protein Translation Apoptotic Process Negative Regulation Of Cell Proliferation Gene Expression Positive Regulation Of Protein Ubiquitination Type II Pneumocyte Differentiation	Small GTPase Mediated Signal Transduction Rho Protein Signal Transduction Positive Regulation Of Rho GTPase Activity Positive Regulation Of Apoptotic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Neurotrophin TRK Receptor Signaling Pathway Regulation Of Small GTPase Mediated Signal Transduction Apoptotic Signaling Pathway
Pathways		Cytosolic tRNA aminoacylation tRNA Aminoacylation	Rho GTPase cycle Signaling by GPCR GPCR downstream signaling Signalling by NGF Cell death signalling via NRAGE, NRIF and NADE Signaling by Rho GTPases NRAGE signals death through JNK G alpha (12/13) signalling events p75 NTR receptor-mediated signalling
Drugs
Diseases
GWAS			Factor VII ( 17903294) Osteoarthritis ( 21871595)
Protein-Protein Interactions		48 interactors: ACTB AIMP1 APP BCAS2 BLOC1S4 BYSL C19orf57 CEP170P1 CHD3 DARS DARS2 DEAF1 DSN1 EPRS EPS8 FGB FHL3 FUBP1 GYS1 ICE1 KARS KDR KIAA1377 KLC2 LMO2 LMO3 LNX1 LUC7L2 MATR3 MCF2L MIS18A NDEL1 NECAB2 NGFRAP1 PARK2 PCMT1 PLEKHF2 PPP2R1A PRKAA2 PSME1 TANK TERF2IP TFIP11 TP53 TRAF2 TRMT2A ZC3H12A ZGPAT	7 interactors: AIMP2 CDC42 RABAC1 RAC1 RHOA RHOG YAE1D1
Entrez ID		7965	23263
HPRD ID		02915	14371
Ensembl ID		ENSG00000106305	ENSG00000126217
Uniprot IDs		A8MU58 Q13155	G5E9A1 O15068
PDB IDs		4DPG
Enriched GO Terms of Interacting Partners?		RNA Metabolic Process Gene Expression Nucleobase-containing Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Nitrogen Compound Metabolic Process Cellular Component Assembly TRNA Aminoacylation For Protein Translation Axon Cargo Transport TRNA Aminoacylation Cell Cycle Process NcRNA Metabolic Process Mitotic Cell Cycle Process Positive Regulation Of Cellular Metabolic Process Regulation Of Autophagy Mitotic Cell Cycle Apoptotic Process Platelet Aggregation Negative Regulation Of Reactive Oxygen Species Metabolic Process Programmed Cell Death Positive Regulation Of Signal Transduction Regulation Of Signal Transduction Regulation Of Mitochondrion Degradation Protein Complex Assembly Microtubule-based Transport Immune System Process Cell Death Death TRNA Metabolic Process Cellular Response To Organic Substance Cytoskeleton-dependent Intracellular Transport Blood Coagulation Cell Cycle Cellular Macromolecule Biosynthetic Process Hemostasis Positive Regulation Of Peptidase Activity Macromolecule Biosynthetic Process Cellular Process Cellular Amino Acid Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Proteolysis Positive Regulation Of Metabolic Process Regulation Of Intracellular Signal Transduction Regulation Of Apoptotic Process Cellular Metabolic Process Response To Wounding Regulation Of Signaling Regulation Of Cellular Ketone Metabolic Process	Axon Guidance Blood Coagulation Hemostasis Ephrin Receptor Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Cell Projection Organization Regulation Of Cell Projection Assembly Axonogenesis Axon Development Regulation Of Body Fluid Levels Cell Morphogenesis Involved In Neuron Differentiation Wound Healing Chemotaxis Actin Cytoskeleton Organization Small GTPase Mediated Signal Transduction Neuron Projection Morphogenesis Actin Filament-based Process Positive Regulation Of Cell Morphogenesis Involved In Differentiation Response To Wounding Cell Morphogenesis Involved In Differentiation Regulation Of Small GTPase Mediated Signal Transduction Platelet Activation Cell-cell Junction Organization Neuron Projection Development Cell Migration Cell Projection Morphogenesis Cell Part Morphogenesis Cell Motility Positive Regulation Of Phosphatidylinositol 3-kinase Activity Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Neuron Development Positive Regulation Of Cell Projection Organization Regulation Of Substrate Adhesion-dependent Cell Spreading Cell Morphogenesis Epithelium Development Positive Regulation Of Cellular Component Biogenesis Substantia Nigra Development Neuron Differentiation Cytoskeleton Organization Positive Regulation Of Cytokinesis Cell Projection Organization Positive Regulation Of Stress Fiber Assembly Locomotion Positive Regulation Of Actin Filament Bundle Assembly Regulation Of Phosphatidylinositol 3-kinase Activity Neural Nucleus Development Regulation Of Cytokinesis Regulation Of Lipid Kinase Activity Rho Protein Signal Transduction Cell Differentiation
Tagcloud ?		4x20 abl abrogated bbb c57 compacts dopaminergic e3 easily endothelium inno irreversible microvessel mitigated mptp nanomolar neurodegeneration neuroprotective nigra nitrative parkin pars pd pharmacokinetic striatum substantia th translated ubiquitously	blocks brefeldin cdc42 cytoskeleton dbs defective dispersal edge encodes enlarged golgi guanine healing limits localized localizes mb microtubule motility osteoarthritis polarization reorient rhogef secretory transforming transport transwell vesicle wound
Tagcloud (Difference) ?		4x20 abl abrogated bbb c57 compacts dopaminergic e3 easily endothelium inno irreversible microvessel mitigated mptp nanomolar neurodegeneration neuroprotective nigra nitrative parkin pars pd pharmacokinetic striatum substantia th translated ubiquitously	blocks brefeldin cdc42 cytoskeleton dbs defective dispersal edge encodes enlarged golgi guanine healing limits localized localizes mb microtubule motility osteoarthritis polarization reorient rhogef secretory transforming transport transwell vesicle wound
Tagcloud (Intersection) ?