AIMP2 and MCF2L

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		AIMP2	MCF2L
Description		aminoacyl tRNA synthetase complex interacting multifunctional protein 2	MCF.2 cell line derived transforming sequence like
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Membrane Aminoacyl-tRNA Synthetase Multienzyme Complex	Extracellular Space Cytoplasm Cytosol Plasma Membrane Endomembrane System Membrane Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane
	Molecular Function	Protein Binding Protein-macromolecule Adaptor Activity Molecular Adaptor Activity	Guanyl-nucleotide Exchange Factor Activity Protein Binding Lipid Binding Phosphatidylinositol Binding
	Biological Process	Translation Apoptotic Process Negative Regulation Of Cell Population Proliferation Protein Ubiquitination Cell Differentiation Positive Regulation Of Protein Ubiquitination Positive Regulation Of Neuron Apoptotic Process Type II Pneumocyte Differentiation Protein-containing Complex Assembly	Positive Regulation Of Rho Protein Signal Transduction Intracellular Signal Transduction Regulation Of Small GTPase Mediated Signal Transduction
Pathways		Selenoamino acid metabolism Cytosolic tRNA aminoacylation Transcriptional and post-translational regulation of MITF-M expression and activity	NRAGE signals death through JNK G alpha (12/13) signalling events RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RHOG GTPase cycle
Drugs
Diseases
GWAS		High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 27863252 32888494)	Coronary artery disease ( 29212778 33020668) Cutaneous malignant melanoma ( 32341527) Diastolic blood pressure ( 27841878) Factor VII ( 17903294) Mean platelet volume ( 32888494) Osteoarthritis ( 21871595) Pulse pressure ( 27841878 30578418) Systolic blood pressure ( 27841878 28135244 30578418)
Interacting Genes		103 interacting genes: AIMP1 APP BCAS2 BEX3 BLOC1S4 BRME1 BYSL C1orf216 CBY2 CEBPA CEP126 CHD3 DARS1 DARS2 DEAF1 DISC1 DRC12 DSN1 EPRS1 EPS8 EXOC8 FGB FHL3 FILNC1 FUBP1 GYS1 ICE1 KARS1 KDR KLC2 KRT31 KRT33B KRT34 KRT36 LMO2 LMO3 LNX1 LUC7L2 MATR3 MCF2L MIR106A MIR107 MIR122 MIR128-1 MIR128-2 MIR138-2 MIR15A MIR18A MIR199A1 MIR19A MIR19B1 MIR19B2 MIR200C MIR205 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR34A MIR34B MIR34C MIR429 MIR451A MIR7-1 MIR7-2 MIR92A2 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7I MIS18A NDEL1 NECAB2 NTAQ1 PFDN6 PLEKHF2 PPP2R1A PRKAA2 PRKN PSME1 RABEP1 SBK3 SLU7 SMURF2 SPATA18 TANK TCP11 TERF2IP TEX12 TFIP11 TRAF2 TRMT2A ZC3H12A ZGPAT	7 interacting genes: AIMP2 CDC42 RABAC1 RAC1 RHOA RHOG YAE1
Entrez ID		7965	23263
HPRD ID		02915	14371
Ensembl ID		ENSG00000106305	ENSG00000126217
Uniprot IDs		A8MU58 Q13155	H0Y4M6 O15068
PDB IDs		4DPG 4YCU 4YCW 5A1N 5A34 5A5H 5Y6L 6ILD 6IY6 6JPV 6K39 8J9S 9DPL
Enriched GO Terms of Interacting Partners?		MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing RISC Complex Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Extracellular Vesicle Negative Regulation Of Gene Expression MiRNA-mediated Gene Silencing By MRNA Destabilization MRNA 3'-UTR Binding MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process MRNA Destabilization RNA Destabilization Positive Regulation Of MRNA Catabolic Process Negative Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of MRNA Metabolic Process Negative Regulation Of Translation Regulation Of MRNA Stability Regulation Of Angiogenesis Negative Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Regulation Of Vasculature Development Regulation Of RNA Stability Negative Regulation Of Cytokine Production Negative Regulation Of Signal Transduction Regulation Of Cell Migration Involved In Sprouting Angiogenesis Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Negative Regulation Of Signaling Negative Regulation Of Cell Communication Negative Regulation Of Protein Metabolic Process Regulation Of Endothelial Cell Migration Negative Regulation Of Endothelial Cell Migration Positive Regulation Of Catabolic Process Negative Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Sprouting Angiogenesis Extracellular Space Regulation Of Macromolecule Metabolic Process Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of MRNA Metabolic Process Negative Regulation Of Cell Migration Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Multicellular Organismal Process Negative Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Cell Motility	Establishment Or Maintenance Of Cell Polarity Wnt Signaling Pathway, Planar Cell Polarity Pathway Positive Regulation Of Stress Fiber Assembly Glutamatergic Synapse Membrane Invagination Non-canonical Wnt Signaling Pathway Postsynapse Actin Filament Organization Positive Regulation Of Actin Filament Bundle Assembly Small GTPase-mediated Signal Transduction G Protein Activity Regulation Of Synapse Organization G Protein-coupled Receptor Signaling Pathway Involved In Heart Process GTPase Activity Regulation Of Actin Cytoskeleton Organization Regulation Of Stress Fiber Assembly Secretory Granule Membrane GTP Binding Actin Cytoskeleton Organization Thioesterase Binding Regulation Of Actin Filament-based Process Actin Filament-based Process Focal Adhesion Protein Kinase Binding Establishment Of Epithelial Cell Apical/basal Polarity Regulation Of Postsynapse Organization Supramolecular Fiber Organization Regulation Of Cytoskeleton Organization GTP-dependent Protein Binding Establishment Of Apical/basal Cell Polarity Positive Regulation Of Supramolecular Fiber Organization Polarized Epithelial Cell Differentiation Cell-cell Junction Organization Establishment Of Monopolar Cell Polarity Establishment Or Maintenance Of Monopolar Cell Polarity Positive Regulation Of Cytoskeleton Organization Rac Protein Signal Transduction Positive Regulation Of Lamellipodium Assembly Cerebral Cortex Cell Migration Establishment Of Epithelial Cell Polarity Regulation Of Ruffle Assembly Phagocytosis, Engulfment Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell-substrate Adhesion Regulation Of Cell Projection Organization Positive Regulation Of Lamellipodium Organization Regulation Of Cell Projection Assembly Regulation Of Lamellipodium Assembly Telencephalon Cell Migration Regulation Of Cell Junction Assembly
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