GC and CUBN

Number of citations of the paper that reports this interaction (PubMedID 11717447)
27

Data Source:
HPRD (in vivo, in vitro)

		GC	CUBN
Description		GC vitamin D binding protein	cubilin
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Cytosol Lysosomal Lumen Extracellular Exosome Blood Microparticle	Cytoplasm Lysosome Lysosomal Membrane Endosome Endoplasmic Reticulum Golgi Apparatus Cytosol Plasma Membrane Brush Border Clathrin-coated Pit Membrane Apical Plasma Membrane Endocytic Vesicle Extrinsic Component Of External Side Of Plasma Membrane Cell Projection Membrane Brush Border Membrane Microvillus Membrane Lysosomal Lumen Receptor Complex Apical Part Of Cell Extracellular Exosome
	Molecular Function	Actin Binding Vitamin D Binding Vitamin Transmembrane Transporter Activity Calcidiol Binding	Calcium Ion Binding Protein Binding Cobalamin Binding Signaling Receptor Activity Cargo Receptor Activity Protein Homodimerization Activity Metal Ion Binding
	Biological Process	Response To Nutrient Levels Vitamin Transmembrane Transport Vitamin D Metabolic Process Vitamin Transport	Tissue Homeostasis Lipid Metabolic Process Endocytosis Receptor-mediated Endocytosis Steroid Metabolic Process Cholesterol Metabolic Process Cobalamin Metabolic Process Response To Bacterium Protein Transport Cobalamin Transport Lipoprotein Transport Establishment Of Localization In Cell
Pathways		Vitamin D (calciferol) metabolism	Vitamin D (calciferol) metabolism Defective AMN causes MGA1 Defective CUBN causes MGA1 HDL clearance Uptake of dietary cobalamins into enterocytes
Drugs		Vitamin D	Hydroxocobalamin
Diseases
GWAS		Bioavailable vitamin D levels in type 2 diabetes ( 34014961) Granulocyte count ( 27863252) Lymphocyte count ( 32888494) Metabolite levels ( 22916037) Monocyte count ( 32888494) Myeloid white cell count ( 27863252) Neonatal total 25-hydroxyvitamin D levels (fetal genetic effect) ( 32047095) Neutrophil count ( 27863252 32888494) Non-alcoholic fatty liver disease histology (other) ( 23213074) Platelet count ( 32888494) Plateletcrit ( 32888494) Refractive error ( 32231278) Serum 25-Hydroxyvitamin D levels ( 29325163 29545823 31841498 33382404) Serum metabolite levels ( 31636271) Serum metabolite levels (CMS) ( 31636271) Serum vitamin D-binding protein levels ( 24740207) Serum vitamin D-binding protein levels in type 2 diabetes ( 34014961) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Vitamin D insufficiency ( 20541252) Vitamin D levels ( 29343764 25208829 22673963 20418485) Vitamin D levels (dietary vitamin D intake interaction) ( 29343764) White blood cell count ( 27863252 32888494)	Binge eating behaviour in bipolar disorder ( 29391396) Bipolar disorder (early vs late onset) ( 34016946) Cholesterol, total ( 24097068) Colorectal cancer ( 25990418) Folate pathway vitamin levels ( 19744961 19303062) High density lipoprotein cholesterol levels ( 30498476) Homocysteine levels ( 23824729) Metabolite levels ( 23823483) Microalbuminuria ( 26631737 31511532) Molybdenum levels ( 26025379) Platelet distribution width ( 27863252) Plateletcrit ( 32888494) Proteinuria ( 30476138) Proteinuria (mild) ( 30476138) Proteinuria (moderate to severe) ( 30476138) Quantitative traits ( 19197348) Superior temporal gyrus volume ( 31530798) Total cholesterol levels ( 28334899) Total grey matter volume ( 31530798) Urate levels ( 31578528) Urinary albumin excretion ( 30220432 21355061) Urinary albumin excretion (no hypertensive medication) ( 30220432) Urinary albumin-to-creatinine ratio ( 30910378 27650483 31511532 26631737 31630189) Urinary albumin-to-creatinine ratio in diabetes ( 31511532) Urinary albumin-to-creatinine ratio in non-diabetics ( 26631737) Vitamin B levels in ischemic stroke ( 25147783) Whole-brain volume ( 21116278)
Interacting Genes		13 interacting genes: ACTA1 ACTA2 ACTC1 C3 CCND3 CDC73 CUBN GRB2 HSP90AA1 LRIF1 LRP2 PIK3R3 SERF2	9 interacting genes: ALB BRCA1 CBL CBLIF GC LGALS3 LRP2 SCGB1A1 TF
Entrez ID		2638	8029
HPRD ID		00749	04296
Ensembl ID		ENSG00000145321	ENSG00000107611
Uniprot IDs		P02774	O60494
PDB IDs		1J78 1J7E 1KW2 1KXP 1LOT 1MA9	3KQ4 6GJE
Enriched GO Terms of Interacting Partners?		Mesenchyme Migration Brush Border Membrane Filopodium Extracellular Exosome Skeletal Muscle Thin Filament Assembly Muscle Contraction Cobalamin Transport Muscle System Process Cell Body Apical Part Of Cell Actin Cytoskeleton Circulatory System Process Blood Microparticle Regulation Of Metabolic Process Myosin Binding Apical Plasma Membrane Cargo Receptor Activity Amyloid-beta Clearance Positive Regulation Of Gene Expression Microvillus Membrane Tissue Morphogenesis Response To External Biotic Stimulus Receptor-mediated Endocytosis Regulation Of Macromolecule Metabolic Process Lamellipodium Positive Regulation Of Metabolic Process Lymphocyte Activation Regulation Of Fibroblast Migration Regulation Of Apoptotic Process Vitamin Transport System Process Regulation Of Programmed Cell Death Phosphotyrosine Residue Binding Positive Regulation Of Hepatic Stellate Cell Contraction C5L2 Anaphylatoxin Chemotactic Receptor Binding Guanyl-nucleotide Exchange Factor Adaptor Activity CTP Binding DATP Binding Renal Phosphate Ion Absorption Leukocyte Activation Sarcomere Cardiac Muscle Tissue Morphogenesis Regulation Of Cellular Component Size Brush Border Protein Destabilization Positive Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Hepatic Stellate Cell Migration Response To Other Organism Vascular Process In Circulatory System	Vitamin Transport Cobalamin Transport Blood Microparticle Extracellular Space Vitamin D Metabolic Process Vitamin Transmembrane Transport Extracellular Region Extracellular Exosome Enterobactin Binding Exogenous Protein Binding Cellular Response To Calcium Ion Starvation Histone H2AK127 Ubiquitin Ligase Activity Negative Regulation Of Programmed Cell Death Histone H2AK129 Ubiquitin Ligase Activity Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Apoptotic Process Protein Autoubiquitination BRCA1-BARD1 Complex Positive Regulation Of Receptor-mediated Endocytosis Response To Growth Factor Regulation Of Endocytosis Calcidiol Binding Lysosomal Lumen Apical Plasma Membrane Disaccharide Binding Negative Regulation Of Immunological Synapse Formation Folate Import Across Plasma Membrane Clathrin-coated Endocytic Vesicle Membrane Positive Regulation Of Oligodendrocyte Progenitor Proliferation Clathrin-coated Pit Endocytic Vesicle Polychlorinated Biphenyl Binding Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Protein-folding Chaperone Binding SH3 Domain Binding Male Gonad Development Cargo Receptor Ligand Activity Negative Regulation Of NK T Cell Activation Negative Regulation Of T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Folate Transmembrane Transport Iron Chaperone Activity Iron Ion Export Across Plasma Membrane Response To Nutrient Levels Regulation Of Receptor-mediated Endocytosis Transmembrane Transport Response To Stress BRCA1-B Complex Regulation Of Rap Protein Signal Transduction Response To Ozone Response To Silicon Dioxide
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