GCC1 and KHSRP

Data Source: HiPPIP (Novel)

		GCC1	KHSRP
Name		GRIP and coiled-coil domain containing 1	KH-type splicing regulatory protein
Structure		No pdb structure
GO Annotations	Cellular Component	Golgi Trans Cisterna Golgi Membrane Cytoplasm Golgi Apparatus Cytosol Membrane	Exosome (RNase Complex) Nucleus Nucleoplasm Cytoplasm Cytosol Membrane
	Molecular Function	Protein Binding Small GTPase Binding	Nucleic Acid Binding DNA Binding RNA Binding MRNA Binding Protein Binding MRNA 3'-UTR AU-rich Region Binding Protein Folding Chaperone
	Biological Process	None	RNA Splicing, Via Transesterification Reactions Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II MRNA Processing Protein Folding RNA Splicing MiRNA Metabolic Process Negative Regulation Of Low-density Lipoprotein Particle Clearance Regulation Of MRNA Stability Negative Regulation Of Nitric Oxide Biosynthetic Process MRNA Transport Positive Regulation Of MRNA Catabolic Process 3'-UTR-mediated MRNA Destabilization Cellular Response To Cytokine Stimulus
Pathways		Retrograde transport at the Trans-Golgi-Network	ATF4 activates genes in response to endoplasmic reticulum stress KSRP (KHSRP) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA
Drugs		None	Resveratrol Artenimol
GWAS		Feeling worry ( 29500382 ) General cognitive ability ( 29844566 ) Intelligence (MTAG) ( 29326435 ) Medication adherence in chronic diseases ( 25317111 ) Refractive error ( 32231278 ) Type 2 diabetes ( 22158537 26818947 30718926 )	No GWAS studies recorded
Interacting Genes		66 interacting genes: ABI2 AMOTL2 APP ARL1 ATF4 ATN1 BIRC2 BRCA1 C1orf94 CCDC33 CCDC85B CEP57 CEP70 COIL CPSF7 DISC1 DNAJA3 DRC4 FAM83A FBF1 FBXO28 FIGNL1 FOSL1 GLI1 GOLGA2 GTF2I HDX ICA1L IKBKG ITSN1 KATNAL1 KDM1A KIAA0753 KIAA1217 KIF5B LCA5 LZTS2 MCRS1 MED4 MEOX1 MID2 NAB2 NAV1 NECAB2 NINL OIP5 PAK5 PPP1R18 PPP1R27 PRPF18 RUNX1 SMARCA2 SMARCD1 SPOP TFIP11 TLE5 TP53BP2 TRIM29 TRIM50 TSC1 USHBP1 UTP14C XIAP ZC4H2 ZFP90 ZNF276	17 interacting genes: A1CF APBB1 BACE1 CEBPA EXOSC2 EXOSC3 GADD45A GSK3B HNRNPA1 HNRNPH1 MALAT1 NRON PARN PTBP2 SLC25A21-AS1 STK3 UBE2I
Entrez ID		79571	8570
HPRD ID		07599	10350
Ensembl ID		ENSG00000179562	ENSG00000088247
Uniprot IDs		A4D0Z4 Q96CN9	M0R0C6 Q92945
PDB IDs		Not available	2HH2 2HH3 2JVZ 2OPU 2OPV 4B8T
GO Terms Enriched among Interactors		Identical Protein Binding Protein Binding Cytoskeleton Microtubule Centrosome Microtubule Severing Transcription Coactivator Activity Microtubule-based Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Cytoplasm Regulation Of DNA Repair Microtubule Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Regulation Of RNA Metabolic Process P53 Binding Microtubule Severing ATPase Activity Regulation Of Primary Metabolic Process Lens Fiber Cell Morphogenesis Ciliary Basal Body Regulation Of Cellular Response To Stress Regulation Of Double-strand Break Repair Negative Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Cellular Response To Manganese Ion Spindle Pole Cytoplasm Organization Microtubule Cytoskeleton Organization Nucleus Negative Regulation Of DNA-templated Transcription Regulation Of Growth Negative Regulation Of RNA Biosynthetic Process Spermatid Development	Poly(A)-dependent SnoRNA 3'-end Processing Sno(s)RNA Metabolic Process MRNA Metabolic Process 3'-5'-RNA Exonuclease Activity CUT Catabolic Process Negative Regulation Of Macromolecule Metabolic Process RNA Processing Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) TRAMP-dependent TRNA Surveillance Pathway TRNA Surveillance Nuclear Polyadenylation-dependent RRNA Catabolic Process U4 SnRNA 3'-end Processing Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process RRNA 3'-end Processing Nucleolar Exosome (RNase Complex) RNA Metabolic Process TRNA Decay RNA 3'-end Processing Cytoplasmic Exosome (RNase Complex) RNA Exonuclease Activity RNA Binding Nucleic Acid Metabolic Process Nuclear Exosome (RNase Complex) Exosome (RNase Complex) Nuclear-transcribed MRNA Catabolic Process Regulation Of Gene Expression Positive Regulation Of Apoptotic Process SnRNA 3'-end Processing Positive Regulation Of Programmed Cell Death Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Telomere Maintenance Via Telomerase Macromolecule Metabolic Process Nucleic Acid Binding MRNA Catabolic Process Positive Regulation Of Telomere Maintenance Via Telomere Lengthening SnRNA Processing Nuclear RNA Surveillance Nucleobase-containing Compound Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process RNA Surveillance Presynaptic Modulation Of Chemical Synaptic Transmission RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Negative Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein Regulation Of Microtubule Anchoring At Centrosome Spliceosomal Complex Regulation Of Telomere Maintenance Via Telomerase Regulation Of RNA Splicing PriRNA 3'-end Processing