PTH and FEZ1

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		PTH	FEZ1
Gene Name		parathyroid hormone	fasciculation and elongation protein zeta 1 (zygin I)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space	Cytoplasm Mitochondrion Centrosome Microtubule Plasma Membrane Microtubule Cytoskeleton Axon Dendrite
	Molecular Function	RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Hormone Activity Parathyroid Hormone Receptor Binding Type 1 Parathyroid Hormone Receptor Binding Peptide Hormone Receptor Binding	Protein Kinase C Binding Protein Binding Gamma-tubulin Binding Protein N-terminus Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Skeletal System Development Transcription From RNA Polymerase II Promoter Cellular Calcium Ion Homeostasis G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Rho Protein Signal Transduction Cell-cell Signaling Hormone-mediated Apoptotic Signaling Pathway Positive Regulation Of Signal Transduction Response To Lead Ion Regulation Of Gene Expression Positive Regulation Of Bone Mineralization Positive Regulation Of CAMP Biosynthetic Process Response To Vitamin D Cellular Macromolecule Biosynthetic Process Response To Drug Bone Resorption Response To Ethanol Positive Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter CAMP Metabolic Process Positive Regulation Of Glucose Import Response To Cadmium Ion Response To Parathyroid Hormone Response To Fibroblast Growth Factor	Transport Cell Adhesion Nervous System Development Axon Guidance Positive Regulation Of Neuron Projection Development Establishment Of Mitochondrion Localization Cellular Response To Growth Factor Stimulus
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling G alpha (s) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding Class B/2 (Secretin family receptors)
Drugs
Diseases
GWAS		Bone mineral density ( 19874204)	Schizophrenia ( 22688191 23894747)
Protein-Protein Interactions		5 interactors: BAG6 FEZ1 MEP1A PTH1R PTH2R	57 interactors: BARD1 BORA BRD1 C16orf59 C8orf33 CCL7 CIB1 CLASP2 COL9A2 CSTF2 DIS3L2 DISC1 DNAAF5 DRAP1 FEZ2 GEMIN7 GTF2F1 HAP1 HTATSF1 HTT IMMT KIAA1377 LRIF1 MEST NBR1 NDUFB9 NEK1 OLFML3 P4HB PAM16 PDCD7 PRKCZ PTH PTN PTPRS RAB3GAP1 RAB3GAP2 RAI14 RIF1 SAP30L SCOC SERPINH1 SMARCD1 SMC3 SMEK2 STAR TAC3 TAF1D TAF9 TBC1D25 TLK2 TOMM20 TTR TXNDC9 UBE4B WWC1 ZNF251
Entrez ID		5741	9638
HPRD ID		01345	09212
Ensembl ID		ENSG00000152266	ENSG00000149557
Uniprot IDs		P01270	Q99689
PDB IDs		1BWX 1ET1 1ET2 1FVY 1HPH 1HPY 1HTH 1ZWA 1ZWB 1ZWD 1ZWE 1ZWF 1ZWG 2L1X 3C4M
Enriched GO Terms of Interacting Partners?			Positive Regulation Of Endoplasmic Reticulum Tubular Network Organization Organelle Organization Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Establishment Of Protein Localization To Endoplasmic Reticulum Membrane Regulation Of Cellular Process Vesicle Transport Along Microtubule Cell Cycle Mitotic Cell Cycle Microtubule-based Process Microtubule Cytoskeleton Organization Regulation Of Metabolic Process Response To Radiation Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Heterocycle Metabolic Process Cellular Process Cellular Homeostasis Organelle Transport Along Microtubule Positive Regulation Of Metabolic Process Response To Ionizing Radiation Response To Stimulus Movement Of Cell Or Subcellular Component Cell Division Regulation Of Intracellular Signal Transduction Cell Cycle Process Regulation Of Synaptic Plasticity Nucleobase-containing Compound Metabolic Process Cellular Response To DNA Damage Stimulus Regulation Of Synaptic Transmission Regulation Of Microtubule-based Process Response To Abiotic Stimulus Cellular Nitrogen Compound Metabolic Process Establishment Or Maintenance Of Cell Polarity Cellular Metabolic Process Mitotic Nuclear Division Mitotic Cell Cycle Process Homeostatic Process Regulation Of Signal Transduction Regulation Of Signaling Mitochondrial Calcium Ion Homeostasis Regulation Of Organelle Organization Cellular Aromatic Compound Metabolic Process Regulation Of Cellular Component Organization Nitrogen Compound Metabolic Process DNA-templated Transcription, Elongation Establishment Of Protein Localization To Organelle Anatomical Structure Development Nervous System Development RNA Metabolic Process Diencephalon Development Transcription, DNA-templated
Tagcloud ?		accurately assay coefficients commercially cr1073m detectable determining egta example fifteen fragments gave gives immunoassay immunoreactive inter interfere interfered intra p55 parathyroid pg porcine proximity scintillation simply spa spiked throughput	atf5 burden credible disc1 disordered endophenotypes highlighting intriguing intrinsically lis maf missense nde1 ndel1 neuropsychiatric partners pde4b psychiatric reside schizophrenia striking swedish synonymous sz traf3ip1 unexplored variants ywhae znf365
Tagcloud (Difference) ?		accurately assay coefficients commercially cr1073m detectable determining egta example fifteen fragments gave gives immunoassay immunoreactive inter interfere interfered intra p55 parathyroid pg porcine proximity scintillation simply spa spiked throughput	atf5 burden credible disc1 disordered endophenotypes highlighting intriguing intrinsically lis maf missense nde1 ndel1 neuropsychiatric partners pde4b psychiatric reside schizophrenia striking swedish synonymous sz traf3ip1 unexplored variants ywhae znf365
Tagcloud (Intersection) ?