PTH and PTH1R

Number of citations of the paper that reports this interaction (PMID 9108031)
6

Data Source:
HPRD (in vivo)

		PTH	PTH1R
Gene Name		parathyroid hormone	parathyroid hormone 1 receptor
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space	Nucleus Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Basolateral Plasma Membrane Apical Plasma Membrane Brush Border Membrane Receptor Complex Extracellular Vesicular Exosome
	Molecular Function	RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Hormone Activity Parathyroid Hormone Receptor Binding Type 1 Parathyroid Hormone Receptor Binding Peptide Hormone Receptor Binding	Parathyroid Hormone Receptor Activity Protein Binding Peptide Hormone Binding Protein Self-association
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Skeletal System Development Transcription From RNA Polymerase II Promoter Cellular Calcium Ion Homeostasis G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Rho Protein Signal Transduction Cell-cell Signaling Hormone-mediated Apoptotic Signaling Pathway Positive Regulation Of Signal Transduction Response To Lead Ion Regulation Of Gene Expression Positive Regulation Of Bone Mineralization Positive Regulation Of CAMP Biosynthetic Process Response To Vitamin D Cellular Macromolecule Biosynthetic Process Response To Drug Bone Resorption Response To Ethanol Positive Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter CAMP Metabolic Process Positive Regulation Of Glucose Import Response To Cadmium Ion Response To Parathyroid Hormone Response To Fibroblast Growth Factor	Skeletal System Development Chondrocyte Differentiation Osteoblast Development G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Aging Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Bone Mineralization Bone Resorption Cell Maturation Positive Regulation Of Inositol Phosphate Biosynthetic Process
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling G alpha (s) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding Class B/2 (Secretin family receptors)	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling G alpha (s) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding Class B/2 (Secretin family receptors)
Drugs
Diseases
GWAS		Bone mineral density ( 19874204)
Protein-Protein Interactions		5 interactors: BAG6 FEZ1 MEP1A PTH1R PTH2R	8 interactors: ARRB1 GNB1 PTH PTHLH SLC9A3R1 SLC9A3R2 UBC YWHAH
Entrez ID		5741	5745
HPRD ID		01345	01347
Ensembl ID		ENSG00000152266	ENSG00000160801
Uniprot IDs		P01270	Q03431 Q0VGD7
PDB IDs		1BWX 1ET1 1ET2 1FVY 1HPH 1HPY 1HTH 1ZWA 1ZWB 1ZWD 1ZWE 1ZWF 1ZWG 2L1X 3C4M	1BL1 1ET2 1ET3 3C4M 3H3G 3KJ5 3L2J
Enriched GO Terms of Interacting Partners?			Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Regulation Of Signal Transduction Regulation Of Signaling Apoptotic Process Programmed Cell Death Cell Death Death Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Negative Regulation Of Phosphatidylinositol 3-kinase Signaling Positive Regulation Of Signal Transduction Regulation Of Sodium Ion Transmembrane Transporter Activity Regulation Of Phosphorus Metabolic Process Dopamine Receptor Signaling Pathway Regulation Of Sodium Ion Transmembrane Transport Positive Regulation Of Cellular Biosynthetic Process CAMP Metabolic Process Chemical Homeostasis Cell Surface Receptor Signaling Pathway Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Apoptotic Signaling Pathway Signal Transduction Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of CAMP Biosynthetic Process Regulation Of Sodium Ion Transport Positive Regulation Of CAMP Metabolic Process Negative Regulation Of Signal Transduction Signaling Cyclic Nucleotide Metabolic Process Cell Communication G-protein Coupled Receptor Signaling Pathway Renal Phosphate Ion Absorption Glucocorticoid Catabolic Process Nipple Sheath Formation Mammary Gland Bud Elongation Positive Regulation Of Cyclic Nucleotide Metabolic Process Cellular Ion Homeostasis Negative Regulation Of Signaling Regulation Of Phosphatidylinositol 3-kinase Signaling Regulation Of CAMP Biosynthetic Process Phototransduction Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Regulation Of CAMP Metabolic Process Negative Regulation Of Protein Ubiquitination Detection Of Light Stimulus Positive Regulation Of Transcription, DNA-templated Cellular Chemical Homeostasis Cellular Response To Oxygen Levels
Tagcloud ?		accurately assay coefficients commercially cr1073m detectable determining egta example fifteen fragments gave gives immunoassay immunoreactive inter interfere interfered intra p55 parathyroid pg porcine proximity scintillation simply spa spiked throughput	293a arrestin arrestin1 b2r bona cargo cargoes cognate colocalization construction cytofluorometric egfp endosomal fide gpcrs hek internalization internalize lysate maximakinin mk preproinsulin rab5 rab7 recipient secretable transporting verify
Tagcloud (Difference) ?		accurately assay coefficients commercially cr1073m detectable determining egta example fifteen fragments gave gives immunoassay immunoreactive inter interfere interfered intra p55 parathyroid pg porcine proximity scintillation simply spa spiked throughput	293a arrestin arrestin1 b2r bona cargo cargoes cognate colocalization construction cytofluorometric egfp endosomal fide gpcrs hek internalization internalize lysate maximakinin mk preproinsulin rab5 rab7 recipient secretable transporting verify
Tagcloud (Intersection) ?