PRRC2A and EIF3E

Number of citations of the paper that reports this interaction (PubMedID 14667819)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		PRRC2A	EIF3E
Description		proline rich coiled-coil 2A	eukaryotic translation initiation factor 3 subunit E
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Membrane Extracellular Exosome	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 3 Complex Postsynaptic Density Membrane Eukaryotic 43S Preinitiation Complex PML Body Protein-containing Complex Eukaryotic 48S Preinitiation Complex Extracellular Exosome Eukaryotic Translation Initiation Factor 3 Complex, EIF3e
	Molecular Function	RNA Binding Protein Binding	RNA Binding Translation Initiation Factor Activity Protein Binding Cadherin Binding
	Biological Process	Cell Differentiation	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Formation Of Cytoplasmic Translation Initiation Complex Cytoplasmic Translational Initiation Translation Translational Initiation Regulation Of Translational Initiation Positive Regulation Of Translation Negative Regulation Of Translational Initiation
Pathways			L13a-mediated translational silencing of Ceruloplasmin expression Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit
Drugs
Diseases
GWAS		A body shape index ( 34021172) Adult body size ( 32376654) Age at first birth ( 34211149) Anxiety ( 33859377) Asthma ( 31619474) Asthma (childhood onset) ( 31619474) Asthma and major depressive disorder ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Childhood body mass index ( 33045005) Hand grip strength ( 29691431) Height ( 28552196) Hemoglobin levels ( 32327693) Hip circumference adjusted for BMI ( 34021172) Inflammatory bowel disease ( 28067908) Leukocyte telomere length ( 32109421) Malaria ( 31844061) Menopause (age at onset) ( 22267201) Metabolite levels ( 31628463) Platelet distribution width ( 32888494) Schizophrenia ( 23894747) Systolic blood pressure ( 30578418) Ulcerative colitis ( 28067908) Waist circumference ( 31928498) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Brain morphology (MOSTest) ( 32665545) Coffee consumption ( 31046077) Dupuytren's disease ( 21732829 28886342) Heel bone mineral density ( 30598549) Macular thickness ( 30535121) Male-pattern baldness ( 28196072) Ossification of the posterior longitudinal ligament of the spine ( 25064007)
Interacting Genes		32 interacting genes: ATN1 ATXN1 C1QBP CCR10 CEBPA CPSF1 DDX20 EIF3E EWSR1 FGA GANAB GORASP2 GRB2 HNRNPA1 HNRNPM IFT88 IMMT JUN MAD2L2 MAN2C1 NEIL3 P4HA2 PRMT2 PSMA3 QARS1 RBFOX1 RBM11 RERE RUNX1 SRPK2 SSR3 UBAP2L	37 interacting genes: ANKHD1 ATM COPS6 COPS7A COPS7B COPS8 DDX24 EIF3C EIF3L EIF4ENIF1 EPAS1 EPN2 GPAA1 GPBP1L1 HAP1 IFIT1 ISCA2 KPRP LINC01554 MAPK1IP1L MIIP MRNIP MSI2 NDRG1 NSF OGT PGCKA1 PRPF31 PRRC2A RPSA RUNDC3A SHBG SMAD9 TRIM27 TRIM55 TRIM63 ZNF48
Entrez ID		7916	3646
HPRD ID		00807	03734
Ensembl ID		ENSG00000204469	ENSG00000104408
Uniprot IDs		A0A1U9X974 A0A1U9X985 A0A1U9X998 A0A1U9X999 A0A1U9X9A9 P48634	P60228
PDB IDs			3J8B 3J8C 6FEC 6YBD 6ZMW 6ZON 6ZP4 6ZVJ 7A09 7QP6 7QP7 8OZ0 8PJ1 8PJ2 8PJ3 8PJ4 8PJ5 8PJ6 8PPL 8RG0 8XXN 9BLN
Enriched GO Terms of Interacting Partners?		Nucleoplasm RNA Binding MRNA Metabolic Process MRNA Processing Regulation Of MRNA Splicing, Via Spliceosome RNA Splicing RNA Metabolic Process Protein Domain Specific Binding Regulation Of MRNA Processing Nucleic Acid Metabolic Process Nucleic Acid Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process RNA Processing Negative Regulation Of Biosynthetic Process Regulation Of RNA Splicing Negative Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Nucleobase-containing Compound Metabolic Process Nuclear Matrix Regulation Of RNA Metabolic Process Negative Regulation Of Metabolic Process Nucleolus Nucleus Regulation Of Alternative MRNA Splicing, Via Spliceosome Negative Regulation Of Transcription By RNA Polymerase II Hydrolase Activity, Acting On Glycosyl Bonds Regulation Of MRNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Transcription Corepressor Activity Regulation Of Macromolecule Biosynthetic Process Poly(U) RNA Binding Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Hematopoietic Stem Cell Proliferation Alternative MRNA Splicing, Via Spliceosome MRNA Binding Negative Regulation Of Double-strand Break Repair Via Homologous Recombination Positive Regulation Of Macromolecule Biosynthetic Process Adrenergic Receptor Binding Cellular Response To Stress RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Negative Regulation Of Blood Coagulation, Common Pathway Guanyl-nucleotide Exchange Factor Adaptor Activity Insulin-like Growth Factor Receptor Signaling Pathway Histone H3R8 Methyltransferase Activity DNA Damage Response, Signal Transduction Resulting In Transcription	Regulation Of Protein Neddylation Protein Deneddylation COP9 Signalosome Assembly COP9 Signalosome Regulation Of Post-translational Protein Modification Protein Neddylation Regulation Of Protein Metabolic Process Protein Modification By Small Protein Removal RNA Binding Negative Regulation Of Cell Cycle G2/M Phase Transition Post-translational Protein Modification Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Cytoplasm Regulation Of Protein Modification Process Formation Of Cytoplasmic Translation Initiation Complex Eukaryotic Translation Initiation Factor 3 Complex Eukaryotic 48S Preinitiation Complex Protein K63-linked Ubiquitination Eukaryotic 43S Preinitiation Complex Protein Modification By Small Protein Conjugation Protein Metabolic Process
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