PRRC2A and MAN2C1

Number of citations of the paper that reports this interaction (PubMedID 14667819)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		PRRC2A	MAN2C1
Description		proline rich coiled-coil 2A	mannosidase alpha class 2C member 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Membrane Extracellular Exosome	Nucleoplasm Cytoplasm Cytosol
	Molecular Function	RNA Binding Protein Binding	Catalytic Activity Alpha-mannosidase Activity Hydrolase Activity Hydrolase Activity, Acting On Glycosyl Bonds Carbohydrate Binding Metal Ion Binding
	Biological Process	Cell Differentiation	Carbohydrate Metabolic Process Mannose Metabolic Process Oligosaccharide Catabolic Process
Pathways			Lysosomal oligosaccharide catabolism
Drugs
Diseases
GWAS		A body shape index ( 34021172) Adult body size ( 32376654) Age at first birth ( 34211149) Anxiety ( 33859377) Asthma ( 31619474) Asthma (childhood onset) ( 31619474) Asthma and major depressive disorder ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Childhood body mass index ( 33045005) Hand grip strength ( 29691431) Height ( 28552196) Hemoglobin levels ( 32327693) Hip circumference adjusted for BMI ( 34021172) Inflammatory bowel disease ( 28067908) Leukocyte telomere length ( 32109421) Malaria ( 31844061) Menopause (age at onset) ( 22267201) Metabolite levels ( 31628463) Platelet distribution width ( 32888494) Schizophrenia ( 23894747) Systolic blood pressure ( 30578418) Ulcerative colitis ( 28067908) Waist circumference ( 31928498) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		32 interacting genes: ATN1 ATXN1 C1QBP CCR10 CEBPA CPSF1 DDX20 EIF3E EWSR1 FGA GANAB GORASP2 GRB2 HNRNPA1 HNRNPM IFT88 IMMT JUN MAD2L2 MAN2C1 NEIL3 P4HA2 PRMT2 PSMA3 QARS1 RBFOX1 RBM11 RERE RUNX1 SRPK2 SSR3 UBAP2L	5 interacting genes: BRCA1 EXOSC6 NLGN3 PRRC2A XRN1
Entrez ID		7916	4123
HPRD ID		00807	01109
Ensembl ID		ENSG00000204469	ENSG00000140400
Uniprot IDs		A0A1U9X974 A0A1U9X985 A0A1U9X998 A0A1U9X999 A0A1U9X9A9 P48634	A0A140VJN9 Q9NTJ4
PDB IDs
Enriched GO Terms of Interacting Partners?		Nucleoplasm RNA Binding MRNA Metabolic Process MRNA Processing Regulation Of MRNA Splicing, Via Spliceosome RNA Splicing RNA Metabolic Process Protein Domain Specific Binding Regulation Of MRNA Processing Nucleic Acid Metabolic Process Nucleic Acid Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process RNA Processing Negative Regulation Of Biosynthetic Process Regulation Of RNA Splicing Negative Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Nucleobase-containing Compound Metabolic Process Nuclear Matrix Regulation Of RNA Metabolic Process Negative Regulation Of Metabolic Process Nucleolus Nucleus Regulation Of Alternative MRNA Splicing, Via Spliceosome Negative Regulation Of Transcription By RNA Polymerase II Hydrolase Activity, Acting On Glycosyl Bonds Regulation Of MRNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Transcription Corepressor Activity Regulation Of Macromolecule Biosynthetic Process Poly(U) RNA Binding Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Hematopoietic Stem Cell Proliferation Alternative MRNA Splicing, Via Spliceosome MRNA Binding Negative Regulation Of Double-strand Break Repair Via Homologous Recombination Positive Regulation Of Macromolecule Biosynthetic Process Adrenergic Receptor Binding Cellular Response To Stress RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Negative Regulation Of Blood Coagulation, Common Pathway Guanyl-nucleotide Exchange Factor Adaptor Activity Insulin-like Growth Factor Receptor Signaling Pathway Histone H3R8 Methyltransferase Activity DNA Damage Response, Signal Transduction Resulting In Transcription	Nuclear MRNA Surveillance RRNA Catabolic Process RNA Surveillance Nuclear RNA Surveillance Regulation Of DNA Metabolic Process RNA Binding Cellular Response To Puromycin Cellular Response To Cycloheximide Nuclear-transcribed MRNA Catabolic Process Histone H2AK127 Ubiquitin Ligase Activity Histone H2AK129 Ubiquitin Ligase Activity BRCA1-BARD1 Complex MRNA Catabolic Process Rhythmic Synaptic Transmission Symmetric, GABA-ergic, Inhibitory Synapse BRCA1-B Complex Asymmetric, Glutamatergic, Excitatory Synapse 5'-3' RNA Exonuclease Activity Negative Regulation Of Centrosome Duplication Negative Regulation Of Centriole Replication BRCA1-A Complex XY Body Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation Lateral Element Nuclear Ubiquitin Ligase Complex Cellular Response To Indole-3-methanol Positive Regulation Of DNA Metabolic Process BRCA1-C Complex Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Gamma-tubulin Ring Complex Ubiquitin-modified Histone Reader Activity Positive Regulation Of Developmental Process Response To Indole-3-methanol DNA Strand Resection Involved In Replication Fork Processing Response To Alcohol DNA Recombination Negative Regulation Of Gene Expression DNA Repair Complex Random Inactivation Of X Chromosome Neurexin Family Protein Binding Regulation Of Respiratory Gaseous Exchange By Nervous System Process Regulation Of Respiratory System Process Inhibitory Postsynaptic Potential Neuron Cell-cell Adhesion Positive Regulation Of Glutamate Receptor Signaling Pathway Postsynaptic Membrane Assembly Postsynaptic Membrane Organization Presynaptic Membrane Assembly Regulation Of Glutamate Receptor Signaling Pathway Neuron To Neuron Synapse
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