EIF3E and IFIT1

Number of citations of the paper that reports this interaction (PubMedID 10644362)
30

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		EIF3E	IFIT1
Description		eukaryotic translation initiation factor 3 subunit E	interferon induced protein with tetratricopeptide repeats 1
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 3 Complex Postsynaptic Density Membrane Eukaryotic 43S Preinitiation Complex PML Body Protein-containing Complex Eukaryotic 48S Preinitiation Complex Extracellular Exosome Eukaryotic Translation Initiation Factor 3 Complex, EIF3e	Cytoplasm Cytosol Host Cell
	Molecular Function	RNA Binding Translation Initiation Factor Activity Protein Binding Cadherin Binding	RNA Binding Enzyme Inhibitor Activity Protein Binding RNA Sequestering Activity
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Formation Of Cytoplasmic Translation Initiation Complex Cytoplasmic Translational Initiation Translation Translational Initiation Regulation Of Translational Initiation Positive Regulation Of Translation Negative Regulation Of Translational Initiation	Immune System Process Response To Virus Intracellular Transport Of Viral Protein In Host Cell Positive Regulation Of Viral Genome Replication Negative Regulation Of Viral Genome Replication Innate Immune Response Defense Response To Virus Response To Other Organism Cellular Response To Type I Interferon Cellular Response To Exogenous DsRNA Antiviral Innate Immune Response Negative Regulation Of Viral Translation
Pathways		L13a-mediated translational silencing of Ceruloplasmin expression Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit	ISG15 antiviral mechanism Interferon alpha/beta signaling
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Coffee consumption ( 31046077) Dupuytren's disease ( 21732829 28886342) Heel bone mineral density ( 30598549) Macular thickness ( 30535121) Male-pattern baldness ( 28196072) Ossification of the posterior longitudinal ligament of the spine ( 25064007)
Interacting Genes		37 interacting genes: ANKHD1 ATM COPS6 COPS7A COPS7B COPS8 DDX24 EIF3C EIF3L EIF4ENIF1 EPAS1 EPN2 GPAA1 GPBP1L1 HAP1 IFIT1 ISCA2 KPRP LINC01554 MAPK1IP1L MIIP MRNIP MSI2 NDRG1 NSF OGT PGCKA1 PRPF31 PRRC2A RPSA RUNDC3A SHBG SMAD9 TRIM27 TRIM55 TRIM63 ZNF48	5 interacting genes: ANXA1 EIF3E IFIT2 IFIT3 WEE2-AS1
Entrez ID		3646	3434
HPRD ID		03734	00983
Ensembl ID		ENSG00000104408	ENSG00000185745
Uniprot IDs		P60228	P09914
PDB IDs		3J8B 3J8C 6FEC 6YBD 6ZMW 6ZON 6ZP4 6ZVJ 7A09 7QP6 7QP7 8OZ0 8PJ1 8PJ2 8PJ3 8PJ4 8PJ5 8PJ6 8PPL 8RG0 8XXN 9BLN	4HOU 5UDI 5UDJ 5UDK 5UDL 5W5H 5W5I 6C6K
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Neddylation Protein Deneddylation COP9 Signalosome Assembly COP9 Signalosome Regulation Of Post-translational Protein Modification Protein Neddylation Regulation Of Protein Metabolic Process Protein Modification By Small Protein Removal RNA Binding Negative Regulation Of Cell Cycle G2/M Phase Transition Post-translational Protein Modification Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Cytoplasm Regulation Of Protein Modification Process Formation Of Cytoplasmic Translation Initiation Complex Eukaryotic Translation Initiation Factor 3 Complex Eukaryotic 48S Preinitiation Complex Protein K63-linked Ubiquitination Eukaryotic 43S Preinitiation Complex Protein Modification By Small Protein Conjugation Protein Metabolic Process
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