EIF3E and EIF3L

Number of citations of the paper that reports this interaction (PMID 11590142)
13

Data Source:
HPRD (in vivo, in vitro)

		EIF3E	EIF3L
Gene Name		eukaryotic translation initiation factor 3, subunit E	eukaryotic translation initiation factor 3, subunit L
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 3 Complex Membrane Eukaryotic 43S Preinitiation Complex PML Body Eukaryotic 48S Preinitiation Complex Extracellular Vesicular Exosome	Eukaryotic Translation Initiation Factor 3 Complex Membrane Eukaryotic 43S Preinitiation Complex Eukaryotic 48S Preinitiation Complex
	Molecular Function	Translation Initiation Factor Activity Protein Binding Poly(A) RNA Binding Protein N-terminus Binding	Translation Initiation Factor Activity Protein Binding Poly(A) RNA Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Formation Of Translation Preinitiation Complex Translation Translational Initiation Regulation Of Translational Initiation Gene Expression Cellular Protein Metabolic Process Negative Regulation Of Translational Initiation	Formation Of Translation Preinitiation Complex Translational Initiation Regulation Of Translational Initiation
Pathways		Ribosomal scanning and start codon recognition Translation initiation complex formation Formation of the ternary complex, and subsequently, the 43S complex GTP hydrolysis and joining of the 60S ribosomal subunit Translation Eukaryotic Translation Initiation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Formation of a pool of free 40S subunits Cap-dependent Translation Initiation L13a-mediated translational silencing of Ceruloplasmin expression
Drugs
Diseases
GWAS		Dupuytren's disease ( 21732829)
Protein-Protein Interactions		25 interactors: ATM C4orf19 COPS6 COPS7A COPS7B COPS8 DDX24 EIF3C EIF3L EIF4ENIF1 EPAS1 GPAA1 GPBP1L1 HAP1 IFIT1 NDRG1 NPM1 NSF PRRC2A RUNDC3A SHBG SMAD9 TRIM27 TRIM55 TRIM63	9 interactors: DNM2 EIF3D EIF3E EIF3K POLR1B RGS2 RRN3 SMAD2 XRN2
Entrez ID		3646	51386
HPRD ID		03734	10932
Ensembl ID		ENSG00000104408	ENSG00000100129
Uniprot IDs		B3KW56 P60228	B0QY90 Q9Y262
PDB IDs
Enriched GO Terms of Interacting Partners?		Cullin Deneddylation Protein Deneddylation Protein Modification By Small Protein Removal Cellular Response To Organic Cyclic Compound Response To Hypoxia Formation Of Translation Preinitiation Complex Ribonucleoprotein Complex Assembly Cellular Response To DsRNA Signaling Cell Communication Posttranscriptional Regulation Of Gene Expression Cellular Protein Metabolic Process Signal Transduction Involved In Mitotic G2 DNA Damage Checkpoint Positive Regulation Of Neurotrophin Production Regulation Of Endoribonuclease Activity Regulation Of EIF2 Alpha Phosphorylation By DsRNA Positive Regulation Of Nonmotile Primary Cilium Assembly Primary Spermatocyte Growth Regulation Of Cell Cycle Process Positive Regulation Of Cell Cycle Process Response To Organic Cyclic Compound Signal Transduction Protein Localization Protein Transport Cellular Protein Modification Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Response To DNA Damage Stimulus Cell Aging Negative Regulation Of Interleukin-2 Secretion Golgi Vesicle Docking Establishment Of Protein Localization Regulation Of Translational Initiation Regulation Of Translation Telomere Maintenance Response To DsRNA Positive Regulation Of Cell Cycle Negative Regulation Of Viral Process DNA Damage Response, Signal Transduction By P53 Class Mediator Double-strand Break Repair Via Homologous Recombination Recombinational Repair Positive Regulation Of Cilium Assembly Regulation Of Ribonuclease Activity Negative Regulation Of Helicase Activity Regulation Of Endodeoxyribonuclease Activity Regulation Of Organelle Transport Along Microtubule Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Regulation Of Metabolic Process Response To Abiotic Stimulus Regulation Of Protein Metabolic Process Aging	Formation Of Translation Preinitiation Complex Posttranscriptional Regulation Of Gene Expression Regulation Of Gene Expression Nucleolus Organization Regulation Of Translational Initiation Regulation Of Translation Ribonucleoprotein Complex Biogenesis Ribonucleoprotein Complex Assembly Regulation Of Metabolic Process Gene Expression Transcription Initiation From RNA Polymerase I Promoter Cellular Macromolecule Biosynthetic Process Cellular Macromolecular Complex Assembly Macromolecule Biosynthetic Process Translational Initiation Transcription From RNA Polymerase I Promoter DNA-templated Transcription, Initiation DNA-templated Transcription, Termination Biosynthetic Process Nucleologenesis Negative Regulation Of Membrane Tubulation Positive Regulation Of Nodal Signaling Pathway Involved In Determination Of Lateral Mesoderm Left/right Asymmetry Formation Of Cytoplasmic Translation Initiation Complex Nucleus Organization Regulation Of Nodal Signaling Pathway Involved In Determination Of Lateral Mesoderm Left/right Asymmetry Zygotic Specification Of Dorsal/ventral Axis Translation RNA Catabolic Process Positive Regulation Of Mesoderm Development Primary MiRNA Processing Regulation Of Adrenergic Receptor Signaling Pathway Regulation Of Nodal Signaling Pathway Common-partner SMAD Protein Phosphorylation Positive Regulation Of Cardiac Muscle Contraction Regulation Of Gene Expression, Epigenetic Cytoplasmic Translational Initiation Negative Regulation Of CAMP-mediated Signaling Positive Regulation Of Activin Receptor Signaling Pathway Cytoplasm Organization Negative Regulation Of Phospholipase Activity RNA Metabolic Process Relaxation Of Vascular Smooth Muscle Cellular Component Assembly Relaxation Of Smooth Muscle Negative Regulation Of Cardiac Muscle Hypertrophy Regulation Of Cellular Component Organization Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Striated Muscle Contraction Negative Regulation Of Muscle Hypertrophy SMAD Protein Complex Assembly
Tagcloud ?		adjacent classification clonality colon contained distant elucidated eukaryotic histopathologic initiation invasion involvement lymph mammalian metastasis microarray mucosa multivariate node paired predict prognosis promoted significance tma translation translational univariate vessel	biologically chromatography complex complexes composed consisting coupled devoid efficient encoding eukaryotic feasible hela incubation initiation native nonessential plasmids prepare programmed rapid reconstitute reconstituted reconstitution subunits system tag translation
Tagcloud (Difference) ?		adjacent classification clonality colon contained distant elucidated histopathologic invasion involvement lymph mammalian metastasis microarray mucosa multivariate node paired predict prognosis promoted significance tma translational univariate vessel	biologically chromatography complex complexes composed consisting coupled devoid efficient encoding feasible hela incubation native nonessential plasmids prepare programmed rapid reconstitute reconstituted reconstitution subunits system tag
Tagcloud (Intersection) ?		eukaryotic initiation translation