EIF3E and NSF

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		EIF3E	NSF
Description		eukaryotic translation initiation factor 3 subunit E	N-ethylmaleimide sensitive factor, vesicle fusing ATPase
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 3 Complex Postsynaptic Density Membrane Eukaryotic 43S Preinitiation Complex PML Body Protein-containing Complex Eukaryotic 48S Preinitiation Complex Extracellular Exosome Eukaryotic Translation Initiation Factor 3 Complex, EIF3e	Cytoplasm Lysosomal Membrane Golgi Apparatus Golgi Stack Cytosol Plasma Membrane Dendritic Shaft GABA-ergic Synapse Postsynaptic Specialization, Intracellular Component
	Molecular Function	RNA Binding Translation Initiation Factor Activity Protein Binding Cadherin Binding	SNARE Binding Nucleotide Binding Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Syntaxin-1 Binding Protein Kinase Binding Syntaxin Binding PDZ Domain Binding Ionotropic Glutamate Receptor Binding Protein-containing Complex Binding Metal Ion Binding ATP-dependent Protein Disaggregase Activity
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Formation Of Cytoplasmic Translation Initiation Complex Cytoplasmic Translational Initiation Translation Translational Initiation Regulation Of Translational Initiation Positive Regulation Of Translation Negative Regulation Of Translational Initiation	Positive Regulation Of Receptor Recycling Potassium Ion Transport Intracellular Protein Transport Exocytosis Intra-Golgi Vesicle-mediated Transport Protein Transport Vesicle-mediated Transport Regulation Of Exocytosis SNARE Complex Disassembly Golgi To Plasma Membrane Protein Transport Plasma Membrane Fusion Positive Regulation Of Protein Catabolic Process
Pathways		L13a-mediated translational silencing of Ceruloplasmin expression Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit	COPII-mediated vesicle transport Trafficking of GluR2-containing AMPA receptors COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic Intra-Golgi traffic Retrograde transport at the Trans-Golgi-Network
Drugs			1-Ethyl-Pyrrolidine-2,5-Dione
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Coffee consumption ( 31046077) Dupuytren's disease ( 21732829 28886342) Heel bone mineral density ( 30598549) Macular thickness ( 30535121) Male-pattern baldness ( 28196072) Ossification of the posterior longitudinal ligament of the spine ( 25064007)	Alcohol use disorder (total score) ( 30336701) Body mass index ( 26426971) Brain morphology (MOSTest) ( 32665545) Cortical surface area ( 32963231) Cortical surface area (global PC1) ( 32198502) Cortical volume ( 32963231) General factor of neuroticism ( 30867560) Handedness (Left-handed vs. non-left-handed) ( 30980028) Handedness (Right-handed vs. non-right-handed) ( 30980028) Hemoglobin levels ( 32327693) Hypertrophic cardiomyopathy ( 33495596) Hypertrophic cardiomyopathy (MTAG) ( 33495596) Intelligence (MTAG) ( 29326435) Intraocular pressure ( 30054594) Macular thickness ( 30535121) Male-pattern baldness ( 28196072) Parkinson's disease ( 21812969 19915575) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Reaction time ( 29844566) Refractive error ( 32231278) Sense of smell ( 26632684) Thyroid stimulating hormone levels ( 30367059)
Interacting Genes		37 interacting genes: ANKHD1 ATM COPS6 COPS7A COPS7B COPS8 DDX24 EIF3C EIF3L EIF4ENIF1 EPAS1 EPN2 GPAA1 GPBP1L1 HAP1 IFIT1 ISCA2 KPRP LINC01554 MAPK1IP1L MIIP MRNIP MSI2 NDRG1 NSF OGT PGCKA1 PRPF31 PRRC2A RPSA RUNDC3A SHBG SMAD9 TRIM27 TRIM55 TRIM63 ZNF48	31 interacting genes: ARRB1 ASPSCR1 CD28 CEP126 DRD2 EIF3E ERG28 ESR1 FILNC1 FUNDC2 GABARAP GABARAPL2 GABBR1 GABBR2 GOSR1 GRIA2 GRIA3 LUC7L2 MEOX2 NAPA NAPG PLK2 PTPN9 RAMP3 RNF10 RPLP1 STX1A STX4 STX8 USO1 VAPA
Entrez ID		3646	4905
HPRD ID		03734	03380
Ensembl ID		ENSG00000104408	ENSG00000073969
Uniprot IDs		P60228	A0A384MTI6 P46459
PDB IDs		3J8B 3J8C 6FEC 6YBD 6ZMW 6ZON 6ZP4 6ZVJ 7A09 7QP6 7QP7 8OZ0 8PJ1 8PJ2 8PJ3 8PJ4 8PJ5 8PJ6 8PPL 8RG0 8XXN 9BLN	6KZQ
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Neddylation Protein Deneddylation COP9 Signalosome Assembly COP9 Signalosome Regulation Of Post-translational Protein Modification Protein Neddylation Regulation Of Protein Metabolic Process Protein Modification By Small Protein Removal RNA Binding Negative Regulation Of Cell Cycle G2/M Phase Transition Post-translational Protein Modification Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Cytoplasm Regulation Of Protein Modification Process Formation Of Cytoplasmic Translation Initiation Complex Eukaryotic Translation Initiation Factor 3 Complex Eukaryotic 48S Preinitiation Complex Protein K63-linked Ubiquitination Eukaryotic 43S Preinitiation Complex Protein Modification By Small Protein Conjugation Protein Metabolic Process	Membrane Fusion SNARE Complex Intracellular Protein Localization SNARE Binding Protein Transport Organelle Localization By Membrane Tethering Vesicle-mediated Transport Intra-Golgi Vesicle-mediated Transport Membrane Docking SNAP Receptor Activity Vesicle Fusion Establishment Of Protein Localization Chemical Synaptic Transmission Organelle Membrane Fusion Trans-synaptic Signaling Synaptic Signaling G Protein-coupled GABA Receptor Activity G Protein-coupled GABA Receptor Complex G Protein-coupled Receptor Heterodimeric Complex Organelle Fusion Intracellular Protein Transport Vesicle Docking Positive Regulation Of Synaptic Transmission Dendritic Spine Regulation Of Protein Localization To Cell Periphery GABA Receptor Complex Golgi Vesicle Transport Soluble NSF Attachment Protein Activity Regulation Of Protein Localization To Membrane Membrane Organization Negative Regulation Of Dopamine Secretion Vesicle Organization Synaptobrevin 2-SNAP-25-syntaxin-1a Complex Modulation Of Chemical Synaptic Transmission Intracellular Transport Regulation Of Postsynaptic Membrane Potential Neuron-glial Cell Signaling Regulation Of Catecholamine Secretion Negative Regulation Of Synaptic Transmission Establishment Of Localization In Cell GABA Receptor Activity AMPA Glutamate Receptor Activity Postsynaptic Membrane Regulation Of Protein Localization To Plasma Membrane ATP-dependent Protein Binding Chloride Channel Inhibitor Activity Synaptic Transmission, Glutamatergic Cell-cell Signaling Syntaxin Binding Endomembrane System
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