EIF3E and EIF3C

Number of citations of the paper that reports this interaction (PMID 10504338)
13

Data Source:
HPRD (two hybrid)

		EIF3E	EIF3C
Gene Name		eukaryotic translation initiation factor 3, subunit E	eukaryotic translation initiation factor 3, subunit C
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 3 Complex Membrane Eukaryotic 43S Preinitiation Complex PML Body Eukaryotic 48S Preinitiation Complex Extracellular Vesicular Exosome	Cytosol Eukaryotic Translation Initiation Factor 3 Complex Eukaryotic 43S Preinitiation Complex Eukaryotic 48S Preinitiation Complex
	Molecular Function	Translation Initiation Factor Activity Protein Binding Poly(A) RNA Binding Protein N-terminus Binding	Translation Initiation Factor Activity Protein Binding Translation Initiation Factor Binding Poly(A) RNA Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Formation Of Translation Preinitiation Complex Translation Translational Initiation Regulation Of Translational Initiation Gene Expression Cellular Protein Metabolic Process Negative Regulation Of Translational Initiation	Formation Of Translation Preinitiation Complex Translation Translational Initiation Regulation Of Translational Initiation Gene Expression Cellular Protein Metabolic Process
Pathways		Ribosomal scanning and start codon recognition Translation initiation complex formation Formation of the ternary complex, and subsequently, the 43S complex GTP hydrolysis and joining of the 60S ribosomal subunit Translation Eukaryotic Translation Initiation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Formation of a pool of free 40S subunits Cap-dependent Translation Initiation L13a-mediated translational silencing of Ceruloplasmin expression	Ribosomal scanning and start codon recognition Translation initiation complex formation Formation of the ternary complex, and subsequently, the 43S complex GTP hydrolysis and joining of the 60S ribosomal subunit Translation Eukaryotic Translation Initiation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Formation of a pool of free 40S subunits Cap-dependent Translation Initiation L13a-mediated translational silencing of Ceruloplasmin expression
Drugs
Diseases
GWAS		Dupuytren's disease ( 21732829)	Crohn's disease ( 21102463) Inflammatory bowel disease ( 23128233) Inflammatory bowel disease (early onset) ( 19915574)
Protein-Protein Interactions		25 interactors: ATM C4orf19 COPS6 COPS7A COPS7B COPS8 DDX24 EIF3C EIF3L EIF4ENIF1 EPAS1 GPAA1 GPBP1L1 HAP1 IFIT1 NDRG1 NPM1 NSF PRRC2A RUNDC3A SHBG SMAD9 TRIM27 TRIM55 TRIM63	15 interactors: AAGAB CALM1 EIF1AX EIF3E EIF3G EIF3J EIF3K HMOX2 MAPK6 NDUFA4L2 PFDN1 RPS6KA3 SMAD9 SNIP1 UBC
Entrez ID		3646	8663
HPRD ID		03734	04889
Ensembl ID		ENSG00000104408	ENSG00000184110
Uniprot IDs		B3KW56 P60228	H3BRV0 Q99613
PDB IDs
Enriched GO Terms of Interacting Partners?		Cullin Deneddylation Protein Deneddylation Protein Modification By Small Protein Removal Cellular Response To Organic Cyclic Compound Response To Hypoxia Formation Of Translation Preinitiation Complex Ribonucleoprotein Complex Assembly Cellular Response To DsRNA Signaling Cell Communication Posttranscriptional Regulation Of Gene Expression Cellular Protein Metabolic Process Signal Transduction Involved In Mitotic G2 DNA Damage Checkpoint Positive Regulation Of Neurotrophin Production Regulation Of Endoribonuclease Activity Regulation Of EIF2 Alpha Phosphorylation By DsRNA Positive Regulation Of Nonmotile Primary Cilium Assembly Primary Spermatocyte Growth Regulation Of Cell Cycle Process Positive Regulation Of Cell Cycle Process Response To Organic Cyclic Compound Signal Transduction Protein Localization Protein Transport Cellular Protein Modification Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Response To DNA Damage Stimulus Cell Aging Negative Regulation Of Interleukin-2 Secretion Golgi Vesicle Docking Establishment Of Protein Localization Regulation Of Translational Initiation Regulation Of Translation Telomere Maintenance Response To DsRNA Positive Regulation Of Cell Cycle Negative Regulation Of Viral Process DNA Damage Response, Signal Transduction By P53 Class Mediator Double-strand Break Repair Via Homologous Recombination Recombinational Repair Positive Regulation Of Cilium Assembly Regulation Of Ribonuclease Activity Negative Regulation Of Helicase Activity Regulation Of Endodeoxyribonuclease Activity Regulation Of Organelle Transport Along Microtubule Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Regulation Of Metabolic Process Response To Abiotic Stimulus Regulation Of Protein Metabolic Process Aging	Formation Of Translation Preinitiation Complex Regulation Of Translational Initiation Translational Initiation Posttranscriptional Regulation Of Gene Expression Regulation Of Translation Ribonucleoprotein Complex Assembly Cellular Protein Metabolic Process Translation Ribonucleoprotein Complex Biogenesis Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Cellular Metabolic Process Protein Metabolic Process Neurotrophin TRK Receptor Signaling Pathway Gene Expression Neurotrophin Signaling Pathway Cellular Response To Growth Factor Stimulus MAPK Cascade Response To Growth Factor Intracellular Signal Transduction Cellular Macromolecular Complex Assembly Toll-like Receptor 5 Signaling Pathway Regulation Of Gene Expression Toll-like Receptor 10 Signaling Pathway Regulation Of DNA-templated Transcription In Response To Stress I-kappaB Kinase/NF-kappaB Signaling Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Signal Transduction By Phosphorylation Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Glycogen Metabolic Process Response To Hypoxia TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Negative Regulation Of Cellular Protein Metabolic Process Toll-like Receptor 4 Signaling Pathway Polysaccharide Metabolic Process Midbrain Development Negative Regulation Of Protein Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Heme Oxidation Toll-like Receptor Signaling Pathway Central Nervous System Development Stress-activated MAPK Cascade Cellular Macromolecule Biosynthetic Process Stress-activated Protein Kinase Signaling Cascade Immune Response-regulating Signaling Pathway
Tagcloud ?		adjacent classification clonality colon contained distant elucidated eukaryotic histopathologic initiation invasion involvement lymph mammalian metastasis microarray mucosa multivariate node paired predict prognosis promoted significance tma translation translational univariate vessel	adr alternatively b16f10 deliver emphasize eukaryote eventually evolving g0 gep hct116 housekeeping hyaluronan kind lnps manipulating mcf7 nar nci polysome res retrieved rnai run seeking sirnas ubiquitously unstable vital
Tagcloud (Difference) ?		adjacent classification clonality colon contained distant elucidated eukaryotic histopathologic initiation invasion involvement lymph mammalian metastasis microarray mucosa multivariate node paired predict prognosis promoted significance tma translation translational univariate vessel	adr alternatively b16f10 deliver emphasize eukaryote eventually evolving g0 gep hct116 housekeeping hyaluronan kind lnps manipulating mcf7 nar nci polysome res retrieved rnai run seeking sirnas ubiquitously unstable vital
Tagcloud (Intersection) ?