PRRC2A and SSR3

Number of citations: 0 (PubMedID 14667819)
Data Source: BioGRID (two hybrid), HPRD (two hybrid)

		PRRC2A	SSR3
Name		proline rich coiled-coil 2A	signal sequence receptor subunit 3
Structure		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Membrane Extracellular Exosome	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane
	Molecular Function	RNA Binding Protein Binding	Protein Binding
	Biological Process	Cell Differentiation	SRP-dependent Cotranslational Protein Targeting To Membrane
Pathways		None	SRP-dependent cotranslational protein targeting to membrane
GWAS		A body shape index ( 34021172 ) Adult body size ( 32376654 ) Age at first birth ( 34211149 ) Anxiety ( 33859377 ) Asthma ( 31619474 ) Asthma (childhood onset) ( 31619474 ) Asthma and major depressive disorder ( 31619474 ) Autism spectrum disorder or schizophrenia ( 28540026 ) Childhood body mass index ( 33045005 ) Hand grip strength ( 29691431 ) Height ( 28552196 ) Hemoglobin levels ( 32327693 ) Hip circumference adjusted for BMI ( 34021172 ) Inflammatory bowel disease ( 28067908 ) Leukocyte telomere length ( 32109421 ) Malaria ( 31844061 ) Menopause (age at onset) ( 22267201 ) Metabolite levels ( 31628463 ) Platelet distribution width ( 32888494 ) Schizophrenia ( 23894747 ) Systolic blood pressure ( 30578418 ) Ulcerative colitis ( 28067908 ) Waist circumference ( 31928498 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 )	Asthma (adult onset) ( 30929738 ) Chronotype ( 30696823 ) Malaria ( 31844061 ) Metabolite levels ( 23823483 ) Testicular germ cell tumor ( 28604732 )
Novel Interactors		None recorded	1 novel interactors: ERBB3
Interacting Genes		32 interacting genes: ATN1 ATXN1 C1QBP CCR10 CEBPA CPSF1 DDX20 EIF3E EWSR1 FGA GANAB GORASP2 GRB2 HNRNPA1 HNRNPM IFT88 IMMT JUN MAD2L2 MAN2C1 NEIL3 P4HA2 PRMT2 PSMA3 QARS1 RBFOX1 RBM11 RERE RUNX1 SRPK2 SSR3 UBAP2L	5 interacting genes: AQP2 PDE4B PRRC2A RABAC1 SSR4
Entrez ID		7916	6747
HPRD ID		00807	16206
Ensembl ID		ENSG00000204469	ENSG00000114850
Uniprot IDs		A0A1U9X974 A0A1U9X985 A0A1U9X998 A0A1U9X999 A0A1U9X9A9 P48634	C9J365 Q9UNL2
PDB IDs		Not available	8B6L
GO Terms Enriched among Interactors		Nucleoplasm RNA Binding MRNA Metabolic Process MRNA Processing Regulation Of MRNA Splicing, Via Spliceosome RNA Splicing RNA Metabolic Process Protein Domain Specific Binding Regulation Of MRNA Processing Nucleic Acid Metabolic Process Nucleic Acid Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process RNA Processing Negative Regulation Of Biosynthetic Process Regulation Of RNA Splicing Negative Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Nucleobase-containing Compound Metabolic Process Nuclear Matrix Regulation Of RNA Metabolic Process Negative Regulation Of Metabolic Process Nucleolus Nucleus Regulation Of Alternative MRNA Splicing, Via Spliceosome Negative Regulation Of Transcription By RNA Polymerase II Hydrolase Activity, Acting On Glycosyl Bonds Regulation Of MRNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Transcription Corepressor Activity Regulation Of Macromolecule Biosynthetic Process Poly(U) RNA Binding Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Hematopoietic Stem Cell Proliferation Alternative MRNA Splicing, Via Spliceosome MRNA Binding Negative Regulation Of Double-strand Break Repair Via Homologous Recombination Positive Regulation Of Macromolecule Biosynthetic Process Adrenergic Receptor Binding Cellular Response To Stress RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Negative Regulation Of Blood Coagulation, Common Pathway Guanyl-nucleotide Exchange Factor Adaptor Activity Insulin-like Growth Factor Receptor Signaling Pathway Histone H3R8 Methyltransferase Activity DNA Damage Response, Signal Transduction Resulting In Transcription	Lumenal Side Of Membrane Polyol Transmembrane Transport Renal Water Transport Response To Water Deprivation Glycerol Transmembrane Transport Water Transmembrane Transporter Activity Cellular Response To Mercury Ion Metanephric Collecting Duct Development Cellular Response To Water Deprivation Glycerol Transmembrane Transporter Activity Response To Mercury Ion Basolateral Plasma Membrane Positive Regulation Of Cardiac Muscle Tissue Development ErbB-3 Class Receptor Binding ERBB3:ERBB2 Complex Neuregulin Receptor Activity ERBB2-ERBB3 Signaling Pathway Schwann Cell Differentiation ERBB3 Signaling Pathway Neuregulin Binding Regulation Of Cardiac Muscle Tissue Development Neutrophil Homeostasis Synaptic Vesicle Negative Regulation Of Relaxation Of Muscle CAMP Catabolic Process Negative Regulation Of Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Negative Regulation Of Relaxation Of Cardiac Muscle Regulation Of Relaxation Of Cardiac Muscle Sec61 Translocon Complex Response To Water Negative Regulation Of Motor Neuron Apoptotic Process Gamma-tubulin Complex Membrane Collecting Duct Development Endocardial Cushion Development Cellular Response To Epinephrine Stimulus Negative Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Water Channel Activity Regulation Of Motor Neuron Apoptotic Process Motor Neuron Apoptotic Process Cyclic Nucleotide Catabolic Process Response To Epinephrine Protein Tyrosine Kinase Activator Activity Regulation Of Relaxation Of Muscle Apical Plasma Membrane Renal Water Homeostasis Plasma Membrane Schwann Cell Development Positive Regulation Of Calcineurin-NFAT Signaling Cascade 3',5'-cyclic-AMP Phosphodiesterase Activity