EIF3E and HAP1

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		EIF3E	HAP1
Gene Name		eukaryotic translation initiation factor 3, subunit E	huntingtin-associated protein 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 3 Complex Membrane Eukaryotic 43S Preinitiation Complex PML Body Eukaryotic 48S Preinitiation Complex Extracellular Vesicular Exosome	Nucleus Mitochondrion Lysosome Autophagic Vacuole Endoplasmic Reticulum Cytoskeleton Synaptic Vesicle Actin Cytoskeleton Inclusion Body Cell Junction Axon
	Molecular Function	Translation Initiation Factor Activity Protein Binding Poly(A) RNA Binding Protein N-terminus Binding	Protein Binding Ion Channel Binding Brain-derived Neurotrophic Factor Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Formation Of Translation Preinitiation Complex Translation Translational Initiation Regulation Of Translational Initiation Gene Expression Cellular Protein Metabolic Process Negative Regulation Of Translational Initiation	Exocytosis Autophagy Synaptic Transmission Brain Development Anterograde Axon Cargo Transport Retrograde Axon Cargo Transport Protein Localization Protein Transport Regulation Of Exocytosis Cerebellum Development Hypothalamus Cell Differentiation Cell Projection Organization Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Positive Regulation Of Synaptic Transmission, GABAergic Positive Regulation Of Neurotrophin Production Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Vesicle Transport Along Microtubule Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Neurogenesis Negative Regulation Of Beta-amyloid Formation Regulation Of Organelle Transport Along Microtubule Positive Regulation Of Nonmotile Primary Cilium Assembly
Pathways		Ribosomal scanning and start codon recognition Translation initiation complex formation Formation of the ternary complex, and subsequently, the 43S complex GTP hydrolysis and joining of the 60S ribosomal subunit Translation Eukaryotic Translation Initiation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Formation of a pool of free 40S subunits Cap-dependent Translation Initiation L13a-mediated translational silencing of Ceruloplasmin expression
Drugs
Diseases
GWAS		Dupuytren's disease ( 21732829)	Esophageal cancer (squamous cell) ( 22960999)
Protein-Protein Interactions		25 interactors: ATM C4orf19 COPS6 COPS7A COPS7B COPS8 DDX24 EIF3C EIF3L EIF4ENIF1 EPAS1 GPAA1 GPBP1L1 HAP1 IFIT1 NDRG1 NPM1 NSF PRRC2A RUNDC3A SHBG SMAD9 TRIM27 TRIM55 TRIM63	68 interactors: APLP1 ATP5J2 BARD1 BRD7 C7orf25 C8orf33 CBX8 CCDC113 CDC73 CDK5RAP2 COL9A2 CRIP1 DCTN1 DDX49 DEFB1 EIF3E FAM173A FEZ1 GADD45G GIT1 GLTSCR2 GPRASP2 HGS HMOX2 HSPA4 HTT IMMT ING5 KAT5 KAT7 KATNBL1 KBTBD7 KPNA2 LRIF1 LUC7L2 MPP3 MRPS9 NAP1L5 NDUFB9 NEUROD1 NIPSNAP3A PABPC4 PCM1 PDCD7 PFDN1 PPID PPOX PSMD11 RER1 RIF1 RPS10 RPS25 SNAPIN SRSF4 STX5 TAF1D TBP TIMM17A TNNT1 TNNT3 TOMM20 TSPYL1 UTP3 VIM ZNF20 ZNF24 ZNF33B ZNF691
Entrez ID		3646	9001
HPRD ID		03734	02972
Ensembl ID		ENSG00000104408	ENSG00000173805
Uniprot IDs		B3KW56 P60228	P54257
PDB IDs
Enriched GO Terms of Interacting Partners?		Cullin Deneddylation Protein Deneddylation Protein Modification By Small Protein Removal Cellular Response To Organic Cyclic Compound Response To Hypoxia Formation Of Translation Preinitiation Complex Ribonucleoprotein Complex Assembly Cellular Response To DsRNA Signaling Cell Communication Posttranscriptional Regulation Of Gene Expression Cellular Protein Metabolic Process Signal Transduction Involved In Mitotic G2 DNA Damage Checkpoint Positive Regulation Of Neurotrophin Production Regulation Of Endoribonuclease Activity Regulation Of EIF2 Alpha Phosphorylation By DsRNA Positive Regulation Of Nonmotile Primary Cilium Assembly Primary Spermatocyte Growth Regulation Of Cell Cycle Process Positive Regulation Of Cell Cycle Process Response To Organic Cyclic Compound Signal Transduction Protein Localization Protein Transport Cellular Protein Modification Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Response To DNA Damage Stimulus Cell Aging Negative Regulation Of Interleukin-2 Secretion Golgi Vesicle Docking Establishment Of Protein Localization Regulation Of Translational Initiation Regulation Of Translation Telomere Maintenance Response To DsRNA Positive Regulation Of Cell Cycle Negative Regulation Of Viral Process DNA Damage Response, Signal Transduction By P53 Class Mediator Double-strand Break Repair Via Homologous Recombination Recombinational Repair Positive Regulation Of Cilium Assembly Regulation Of Ribonuclease Activity Negative Regulation Of Helicase Activity Regulation Of Endodeoxyribonuclease Activity Regulation Of Organelle Transport Along Microtubule Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Regulation Of Metabolic Process Response To Abiotic Stimulus Regulation Of Protein Metabolic Process Aging	Cellular Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Nitrogen Compound Metabolic Process Gene Expression RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Cytoplasmic Transport Intracellular Transport Establishment Of Localization In Cell Establishment Of Protein Localization To Organelle RNA Biosynthetic Process Organelle Organization Protein Localization To Organelle Viral Process Protein Targeting Negative Regulation Of Cellular Metabolic Process Cellular Localization Regulation Of Metabolic Process Regulation Of Gene Expression Cellular Process Cellular Macromolecule Biosynthetic Process Transcription, DNA-templated Macromolecule Biosynthetic Process Mitochondrial Transport Regulation Of Nitrogen Compound Metabolic Process Intracellular Protein Transport Actin-myosin Filament Sliding Muscle Filament Sliding Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Cellular Protein Localization Biosynthetic Process Protein Transport Endosomal Transport Cellular Metabolic Process Actin-mediated Cell Contraction Protein Localization Establishment Of Protein Localization Microtubule-based Transport Cytoskeleton-dependent Intracellular Transport MRNA Metabolic Process Chromatin Organization Cell Cycle Regulation Of Cell Cycle Protein Transmembrane Transport Actin Filament-based Movement Organelle Localization Protein Targeting To Mitochondrion Negative Regulation Of Neurogenesis
Tagcloud ?		adjacent classification clonality colon contained distant elucidated eukaryotic histopathologic initiation invasion involvement lymph mammalian metastasis microarray mucosa multivariate node paired predict prognosis promoted significance tma translation translational univariate vessel	autism axons cognition elucidated hippocampal huntingtin impairs knockdown morphogenesis mtorc1 neurons partner phenotypes polarity positioning profoundly proteomics pyramidal recapitulate reflected s6 specification supernumerary suppresses tsc tsc1 tsc2 tuberous uncover
Tagcloud (Difference) ?		adjacent classification clonality colon contained distant eukaryotic histopathologic initiation invasion involvement lymph mammalian metastasis microarray mucosa multivariate node paired predict prognosis promoted significance tma translation translational univariate vessel	autism axons cognition hippocampal huntingtin impairs knockdown morphogenesis mtorc1 neurons partner phenotypes polarity positioning profoundly proteomics pyramidal recapitulate reflected s6 specification supernumerary suppresses tsc tsc1 tsc2 tuberous uncover
Tagcloud (Intersection) ?		elucidated