PRRC2A and P4HA2

Number of citations: 0 (PubMedID 14667819)
Data Source: HPRD (two hybrid)

		PRRC2A	P4HA2
Name		proline rich coiled-coil 2A	prolyl 4-hydroxylase subunit alpha 2
Structure		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Membrane Extracellular Exosome	Nucleoplasm Endoplasmic Reticulum Endoplasmic Reticulum Lumen Cytosol
	Molecular Function	RNA Binding Protein Binding	Procollagen-proline 4-dioxygenase Activity Iron Ion Binding Protein Binding Electron Transfer Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen L-ascorbic Acid Binding Metal Ion Binding Dioxygenase Activity
	Biological Process	Cell Differentiation	None
Pathways		None	Collagen biosynthesis and modifying enzymes
Drugs		None	Proline
GWAS		A body shape index ( 34021172 ) Adult body size ( 32376654 ) Age at first birth ( 34211149 ) Anxiety ( 33859377 ) Asthma ( 31619474 ) Asthma (childhood onset) ( 31619474 ) Asthma and major depressive disorder ( 31619474 ) Autism spectrum disorder or schizophrenia ( 28540026 ) Childhood body mass index ( 33045005 ) Hand grip strength ( 29691431 ) Height ( 28552196 ) Hemoglobin levels ( 32327693 ) Hip circumference adjusted for BMI ( 34021172 ) Inflammatory bowel disease ( 28067908 ) Leukocyte telomere length ( 32109421 ) Malaria ( 31844061 ) Menopause (age at onset) ( 22267201 ) Metabolite levels ( 31628463 ) Platelet distribution width ( 32888494 ) Schizophrenia ( 23894747 ) Systolic blood pressure ( 30578418 ) Ulcerative colitis ( 28067908 ) Waist circumference ( 31928498 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 )	Asthma ( 31619474 ) Asthma or allergic disease (pleiotropy) ( 29785011 ) Brain morphology (MOSTest) ( 32665545 ) Cortical surface area (MOSTest) ( 32665545 ) Crohn's disease ( 22412388 28067908 ) Giant cell arteritis ( 28041642 ) Height ( 28552196 ) Inflammatory bowel disease ( 28067908 ) Intracranial aneurysm ( 33199917 ) Intraocular pressure ( 29617998 ) Subcortical volume (MOSTest) ( 32665545 ) Sum eosinophil basophil counts ( 27863252 ) Ulcerative colitis ( 28067908 ) Youthful appearance (self-reported) ( 32339537 )
Novel Interactors		None recorded	2 novel interactors: CD86 PRKAR2A
Interacting Genes		32 interacting genes: ATN1 ATXN1 C1QBP CCR10 CEBPA CPSF1 DDX20 EIF3E EWSR1 FGA GANAB GORASP2 GRB2 HNRNPA1 HNRNPM IFT88 IMMT JUN MAD2L2 MAN2C1 NEIL3 P4HA2 PRMT2 PSMA3 QARS1 RBFOX1 RBM11 RERE RUNX1 SRPK2 SSR3 UBAP2L	7 interacting genes: CLNK CREB3 FHL3 OGT P4HB PRRC2A TNS4
Entrez ID		7916	8974
HPRD ID		00807	11862
Ensembl ID		ENSG00000204469	ENSG00000072682
Uniprot IDs		A0A1U9X974 A0A1U9X985 A0A1U9X998 A0A1U9X999 A0A1U9X9A9 P48634	O15460 Q05DA4
PDB IDs		Not available	6EVL 6EVM 6EVN 6EVO 6EVP 7ZSC
GO Terms Enriched among Interactors		Nucleoplasm RNA Binding MRNA Metabolic Process MRNA Processing Regulation Of MRNA Splicing, Via Spliceosome RNA Splicing RNA Metabolic Process Protein Domain Specific Binding Regulation Of MRNA Processing Nucleic Acid Metabolic Process Nucleic Acid Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process RNA Processing Negative Regulation Of Biosynthetic Process Regulation Of RNA Splicing Negative Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Nucleobase-containing Compound Metabolic Process Nuclear Matrix Regulation Of RNA Metabolic Process Negative Regulation Of Metabolic Process Nucleolus Nucleus Regulation Of Alternative MRNA Splicing, Via Spliceosome Negative Regulation Of Transcription By RNA Polymerase II Hydrolase Activity, Acting On Glycosyl Bonds Regulation Of MRNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Transcription Corepressor Activity Regulation Of Macromolecule Biosynthetic Process Poly(U) RNA Binding Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Hematopoietic Stem Cell Proliferation Alternative MRNA Splicing, Via Spliceosome MRNA Binding Negative Regulation Of Double-strand Break Repair Via Homologous Recombination Positive Regulation Of Macromolecule Biosynthetic Process Adrenergic Receptor Binding Cellular Response To Stress RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Negative Regulation Of Blood Coagulation, Common Pathway Guanyl-nucleotide Exchange Factor Adaptor Activity Insulin-like Growth Factor Receptor Signaling Pathway Histone H3R8 Methyltransferase Activity DNA Damage Response, Signal Transduction Resulting In Transcription	Focal Adhesion