PRRC2A and FGA

Number of citations of the paper that reports this interaction (PMID 14667819)
24

Data Source:
HPRD (two hybrid)

		PRRC2A	FGA
Gene Name		proline-rich coiled-coil 2A	fibrinogen alpha chain
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Membrane Intracellular Membrane-bounded Organelle Extracellular Vesicular Exosome	Extracellular Region Fibrinogen Complex Extracellular Space Plasma Membrane Cell Cortex External Side Of Plasma Membrane Cell Surface Platelet Alpha Granule Platelet Alpha Granule Lumen Vesicle Extracellular Vesicular Exosome Blood Microparticle
	Molecular Function	Protein Binding Poly(A) RNA Binding	Receptor Binding Structural Molecule Activity Protein Binding Protein Binding, Bridging Cell Adhesion Molecule Binding
	Biological Process		Platelet Degranulation Cell-matrix Adhesion Signal Transduction Blood Coagulation Platelet Activation Extracellular Matrix Organization Positive Regulation Of Heterotypic Cell-cell Adhesion Cellular Protein Complex Assembly Innate Immune Response Positive Regulation Of Vasoconstriction Positive Regulation Of Exocytosis Positive Regulation Of Protein Secretion Protein Polymerization Response To Calcium Ion Positive Regulation Of ERK1 And ERK2 Cascade Platelet Aggregation Blood Coagulation, Common Pathway Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Blood Coagulation, Common Pathway Negative Regulation Of Endothelial Cell Apoptotic Process
Pathways			p130Cas linkage to MAPK signaling for integrins Integrin alphaIIb beta3 signaling Platelet degranulation GRB2:SOS provides linkage to MAPK signaling for Integrins Platelet Aggregation (Plug Formation) Formation of Fibrin Clot (Clotting Cascade) Common Pathway Amyloids Response to elevated platelet cytosolic Ca2+ Integrin cell surface interactions Platelet activation, signaling and aggregation
Drugs			Alteplase Reteplase Anistreplase Tenecteplase Sucralfate Alpha-D-Mannose
Diseases
GWAS		Menopause (age at onset) ( 22267201) Schizophrenia ( 23894747)	D-dimer levels ( 21502573) Fibrinogen ( 20031577 21757653) Venous thromboembolism ( 21980494)
Protein-Protein Interactions		27 interactors: ATN1 ATXN1 C1QBP CCR10 CPSF1 DDX20 EIF3E EWSR1 FGA GANAB GORASP2 GRB2 HNRNPA1 HNRNPM IFT88 IMMT JUN MAD2L2 MAN2C1 P4HA2 PRMT2 PSMA3 QARS RBFOX1 RERE SSR3 UBAP2L	15 interactors: CDH5 F13A1 F2 FGB FGG HRG ITGA2B ITGB3 NID1 PLAT PRRC2A SERPINA5 SERPINF2 THBS1 UBC
Entrez ID		7916	2243
HPRD ID		00807	00619
Ensembl ID		ENSG00000204469	ENSG00000171560
Uniprot IDs		P48634	P02671
PDB IDs			1BBR 1DM4 1FZA 1FZB 1FZC 1FZD 1FZE 1FZF 1FZG 1LT9 1LTJ 1N86 1N8E 1RE3 1RE4 1RF0 1RF1 1YCP 2A45 2FFD 2H43 2HLO 2HOD 2HPC 2OYH 2OYI 2Q9I 2XNX 2XNY 2Z4E 3AT0 3BVH 3E1I 3GHG 3H32 3HUS 4F27
Enriched GO Terms of Interacting Partners?		Gene Expression MRNA Metabolic Process RNA Splicing RNA Metabolic Process RNA Processing MRNA Processing Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Nucleocytoplasmic Transport Nuclear Transport Heterocycle Metabolic Process Nitrogen Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Cellular Nitrogen Compound Metabolic Process Cytoplasmic Transport MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription, DNA-templated Signal Transduction In Response To DNA Damage Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of RNA Biosynthetic Process Cellular Aromatic Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Nuclear Export Nuclear Import Negative Regulation Of Protein Metabolic Process Positive Regulation Of Substrate Adhesion-dependent Cell Spreading RNA Transport Negative Regulation Of Mitotic Cell Cycle Phase Transition RNA Localization Regulation Of Substrate Adhesion-dependent Cell Spreading Cellular Metabolic Process Ribonucleoprotein Complex Assembly Negative Regulation Of Signal Transduction Glutaminyl-tRNA Aminoacylation Negative Regulation Of Blood Coagulation, Common Pathway Blood Coagulation, Common Pathway Cellular Response To Potassium Ion Starvation Negative Regulation Of DNA Binding Negative Regulation Of Signaling Regulation Of Cell Morphogenesis Innate Immune Response Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Mitotic Cell Cycle	Platelet Degranulation Blood Coagulation Hemostasis Platelet Activation Regulation Of Body Fluid Levels Wound Healing Response To Wounding Exocytosis Negative Regulation Of Fibrinolysis Cell Activation Regulation Of Fibrinolysis Secretion By Cell Extracellular Matrix Organization Extracellular Structure Organization Secretion Fibrinolysis Regulation Of Blood Coagulation Positive Regulation Of Blood Coagulation Positive Regulation Of Cell-substrate Adhesion Platelet Aggregation Response To Stress Positive Regulation Of Coagulation Regulation Of Wound Healing Negative Regulation Of Protein Metabolic Process Positive Regulation Of Wound Healing Negative Regulation Of Blood Coagulation Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Cell-matrix Adhesion Negative Regulation Of Coagulation Regulation Of Proteolysis Positive Regulation Of Cell Adhesion Negative Regulation Of Wound Healing Regulation Of Protein Processing Regulation Of Cell-substrate Adhesion Cell-substrate Adhesion Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Phosphorylation Positive Regulation Of Phosphorylation Establishment Of Localization In Cell Vesicle-mediated Transport Regulation Of Phosphorus Metabolic Process Regulation Of Cell Adhesion Regulation Of Endothelial Cell Apoptotic Process Cellular Localization Negative Regulation Of Endothelial Cell Chemotaxis Cell Adhesion Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Signal Transduction Regulation Of Cellular Response To Growth Factor Stimulus
Tagcloud ?			antipsychotic antipsychotics app began caution combinations commonly concurrent contrasts dementia exploring hazardous hospitalized hypnotics monotherapy odds polypharmacy prescribed prescribing quetiapine risperidone schizophrenia sedatives sga taiwan tolerability trends warning warranted
Tagcloud (Difference) ?			antipsychotic antipsychotics app began caution combinations commonly concurrent contrasts dementia exploring hazardous hospitalized hypnotics monotherapy odds polypharmacy prescribed prescribing quetiapine risperidone schizophrenia sedatives sga taiwan tolerability trends warning warranted
Tagcloud (Intersection) ?