DPM2

Description		dolichyl-phosphate mannosyltransferase subunit 2, regulatory
Image		No pdb structure
GO Annotations	Cellular Component	Glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) Complex Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Dolichol-phosphate-mannose Synthase Complex
	Molecular Function	Protein Binding Enzyme Activator Activity Enzyme Regulator Activity
	Biological Process	Protein Glycosylation Dolichol-linked Oligosaccharide Biosynthetic Process GPI Anchor Biosynthetic Process Dolichol Phosphate Mannose Biosynthetic Process
Pathways		Synthesis of dolichyl-phosphate mannose Synthesis of glycosylphosphatidylinositol (GPI) Defective DPM1 causes DPM1-CDG Defective DPM3 causes DPM3-CDG Defective DPM2 causes DPM2-CDG
Drugs
Diseases
GWAS		Body mass index ( 26426971) Glaucoma (primary angle closure) ( 27064256)
Interacting Genes		7 interacting genes: DPM1 DPM3 HLA-DMB PIGA PIGC SLC22A2 VKORC1
Entrez ID		8818
HPRD ID		16028
Ensembl ID		ENSG00000136908
Uniprot IDs		O94777
PDB IDs
Enriched GO Terms of Interacting Partners?		Glycolipid Biosynthetic Process Glycolipid Metabolic Process GPI Anchor Metabolic Process GPI Anchor Biosynthetic Process Dolichol-phosphate-mannose Synthase Complex Membrane Lipid Metabolic Process Phospholipid Biosynthetic Process Dolichol Phosphate Mannose Biosynthetic Process Glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) Complex Phospholipid Metabolic Process Phosphatidylinositol Biosynthetic Process Protein O-linked Glycosylation Via Mannose Endoplasmic Reticulum Membrane Phosphatidylinositol Metabolic Process Carbohydrate Derivative Biosynthetic Process Lipid Biosynthetic Process Organophosphate Biosynthetic Process Glycerophospholipid Biosynthetic Process Isoprenoid Biosynthetic Process Endoplasmic Reticulum Glycerophospholipid Metabolic Process Carbohydrate Derivative Metabolic Process Glycerolipid Metabolic Process Organophosphate Metabolic Process MHC Class II Protein Complex Assembly Dolichyl-phosphate Beta-D-mannosyltransferase Activity Endoplasmic Reticulum-plasma Membrane Adaptor Activity Vitamin-K-epoxide Reductase (warfarin-insensitive) Activity Lipid Metabolic Process Terpenoid Metabolic Process Pyrimidine Nucleoside Transmembrane Transporter Activity Amine Transmembrane Transporter Activity Isoprenoid Metabolic Process Alcohol Binding Peptidyl-glutamic Acid Carboxylation Oxidoreductase Activity, Acting On CH Or CH2 Groups, Disulfide As Acceptor Vitamin-K-epoxide Reductase (warfarin-sensitive) Activity Protein O-linked Glycosylation Positive Regulation Of T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Phosphate-containing Compound Metabolic Process Histamine Uptake Putrescine Transmembrane Transporter Activity Membrane Phosphatidylinositol N-acetylglucosaminyltransferase Activity Acetylcholine Transport Epinephrine Transport Spermidine Transmembrane Transport Putrescine Transport Spermidine Transmembrane Transporter Activity L-arginine Import Across Plasma Membrane
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