DPM2 and DPM3

Number of citations of the paper that reports this interaction (PubMedID 10835346)
31

Data Source:
HPRD (in vivo)

		DPM2	DPM3
Description		dolichyl-phosphate mannosyltransferase subunit 2, regulatory	dolichyl-phosphate mannosyltransferase subunit 3, regulatory
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) Complex Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Dolichol-phosphate-mannose Synthase Complex	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Dolichol-phosphate-mannose Synthase Complex
	Molecular Function	Protein Binding Enzyme Activator Activity Enzyme Regulator Activity	Protein Binding Enzyme Activator Activity Endoplasmic Reticulum-plasma Membrane Adaptor Activity
	Biological Process	Protein Glycosylation Dolichol-linked Oligosaccharide Biosynthetic Process GPI Anchor Biosynthetic Process Dolichol Phosphate Mannose Biosynthetic Process	Protein Glycosylation Protein O-linked Glycosylation Via Mannose Dolichol Phosphate Mannose Biosynthetic Process
Pathways		Synthesis of dolichyl-phosphate mannose Synthesis of glycosylphosphatidylinositol (GPI) Defective DPM1 causes DPM1-CDG Defective DPM3 causes DPM3-CDG Defective DPM2 causes DPM2-CDG	Synthesis of dolichyl-phosphate mannose Defective DPM1 causes DPM1-CDG Defective DPM3 causes DPM3-CDG Defective DPM2 causes DPM2-CDG
Drugs
Diseases
GWAS		Body mass index ( 26426971) Glaucoma (primary angle closure) ( 27064256)	Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Crohn's disease ( 28067908) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Estimated glomerular filtration rate in non-diabetics ( 31451708) Inflammatory bowel disease ( 28067908) Liver enzyme levels (gamma-glutamyl transferase) ( 22001757) Prostate cancer ( 23535732) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Urate levels ( 31578528) Urinary albumin-to-creatinine ratio ( 31630189)
Interacting Genes		7 interacting genes: DPM1 DPM3 HLA-DMB PIGA PIGC SLC22A2 VKORC1	6 interacting genes: DPM1 DPM2 FAM177A1 IER3IP1 SEC22B TMEM147
Entrez ID		8818	54344
HPRD ID		16028	16179
Ensembl ID		ENSG00000136908	ENSG00000179085
Uniprot IDs		O94777	A0A140VJI4 Q86TM7 Q9P2X0
PDB IDs
Enriched GO Terms of Interacting Partners?		Glycolipid Biosynthetic Process Glycolipid Metabolic Process GPI Anchor Metabolic Process GPI Anchor Biosynthetic Process Dolichol-phosphate-mannose Synthase Complex Membrane Lipid Metabolic Process Phospholipid Biosynthetic Process Dolichol Phosphate Mannose Biosynthetic Process Glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) Complex Phospholipid Metabolic Process Phosphatidylinositol Biosynthetic Process Protein O-linked Glycosylation Via Mannose Endoplasmic Reticulum Membrane Phosphatidylinositol Metabolic Process Carbohydrate Derivative Biosynthetic Process Lipid Biosynthetic Process Organophosphate Biosynthetic Process Glycerophospholipid Biosynthetic Process Isoprenoid Biosynthetic Process Endoplasmic Reticulum Glycerophospholipid Metabolic Process Carbohydrate Derivative Metabolic Process Glycerolipid Metabolic Process Organophosphate Metabolic Process MHC Class II Protein Complex Assembly Dolichyl-phosphate Beta-D-mannosyltransferase Activity Endoplasmic Reticulum-plasma Membrane Adaptor Activity Vitamin-K-epoxide Reductase (warfarin-insensitive) Activity Lipid Metabolic Process Terpenoid Metabolic Process Pyrimidine Nucleoside Transmembrane Transporter Activity Amine Transmembrane Transporter Activity Isoprenoid Metabolic Process Alcohol Binding Peptidyl-glutamic Acid Carboxylation Oxidoreductase Activity, Acting On CH Or CH2 Groups, Disulfide As Acceptor Vitamin-K-epoxide Reductase (warfarin-sensitive) Activity Protein O-linked Glycosylation Positive Regulation Of T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Phosphate-containing Compound Metabolic Process Histamine Uptake Putrescine Transmembrane Transporter Activity Membrane Phosphatidylinositol N-acetylglucosaminyltransferase Activity Acetylcholine Transport Epinephrine Transport Spermidine Transmembrane Transport Putrescine Transport Spermidine Transmembrane Transporter Activity L-arginine Import Across Plasma Membrane	Dolichol Phosphate Mannose Biosynthetic Process Dolichol-phosphate-mannose Synthase Complex Endoplasmic Reticulum Membrane Dolichol-linked Oligosaccharide Biosynthetic Process GPI Anchor Metabolic Process Isoprenoid Biosynthetic Process Endoplasmic Reticulum GPI Anchor Biosynthetic Process Glycolipid Biosynthetic Process Dolichyl-phosphate Beta-D-mannosyltransferase Activity Glycolipid Metabolic Process Terpenoid Metabolic Process Isoprenoid Metabolic Process Phosphatidylinositol Biosynthetic Process Alcohol Binding Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Phosphatidylinositol Metabolic Process Protein Glycosylation Macromolecule Glycosylation Protein Localization To Nuclear Inner Membrane Positive Regulation Of Extracellular Matrix Constituent Secretion Glycosylation Glycerophospholipid Biosynthetic Process Membrane Lipid Metabolic Process Phospholipid Biosynthetic Process Glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) Complex Regulation Of Extracellular Matrix Constituent Secretion Glycerophospholipid Metabolic Process Multi-pass Transmembrane Protein Insertion Into ER Membrane Multi-pass Translocon Complex Type B Pancreatic Cell Differentiation Protein O-linked Glycosylation Via Mannose GDP-mannose Metabolic Process Golgi Vesicle Transport Negative Regulation Of Autophagosome Assembly Glycerolipid Metabolic Process Protein Localization To Nuclear Envelope Phospholipid Metabolic Process Enteroendocrine Cell Differentiation Insulin Metabolic Process Establishment Of Protein Localization Regulation Of Fibroblast Apoptotic Process Protein N-linked Glycosylation Via Asparagine D-mannose Binding Positive Regulation Of Extracellular Matrix Organization Enzyme Regulator Activity Carbohydrate Derivative Biosynthetic Process Protein Insertion Into ER Membrane Cellular Localization Lipid Biosynthetic Process
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