DPM2 and DPM3

Number of citations of the paper that reports this interaction (PMID 10835346)
25

Data Source:
HPRD (in vivo)

		DPM2	DPM3
Gene Name		dolichyl-phosphate mannosyltransferase polypeptide 2, regulatory subunit	dolichyl-phosphate mannosyltransferase polypeptide 3
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) Complex Endoplasmic Reticulum Membrane Integral Component Of Endoplasmic Reticulum Membrane Dolichol-phosphate-mannose Synthase Complex Perinuclear Region Of Cytoplasm	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Integral Component Of Endoplasmic Reticulum Membrane Mannosyltransferase Complex Dolichol-phosphate-mannose Synthase Complex
	Molecular Function	Dolichyl-phosphate Beta-D-mannosyltransferase Activity Protein Binding Enzyme Regulator Activity	Dolichyl-phosphate Beta-D-mannosyltransferase Activity Protein Binding
	Biological Process	Dolichol-linked Oligosaccharide Biosynthetic Process C-terminal Protein Lipidation GPI Anchor Biosynthetic Process Preassembly Of GPI Anchor In ER Membrane Protein N-linked Glycosylation Via Asparagine Dolichol Metabolic Process Regulation Of Protein Stability Protein O-linked Mannosylation Post-translational Protein Modification Cellular Protein Metabolic Process Regulation Of Catalytic Activity	Carbohydrate Metabolic Process Dolichol-linked Oligosaccharide Biosynthetic Process C-terminal Protein Lipidation GPI Anchor Biosynthetic Process Protein N-linked Glycosylation Via Asparagine Protein C-linked Glycosylation Via 2'-alpha-mannosyl-L-tryptophan Regulation Of Protein Stability Protein Mannosylation Protein O-linked Mannosylation Post-translational Protein Modification Cellular Protein Metabolic Process
Pathways		Diseases of glycosylation Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS) Defective ALG1 causes ALG1-CDG (CDG-1k) Defective MGAT2 causes MGAT2-CDG (CDG-2a) Defective MOGS causes MOGS-CDG (CDG-2b) Synthesis of glycosylphosphatidylinositol (GPI) Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein Defective ALG9 causes ALG9-CDG (CDG-1l) Synthesis of dolichyl-phosphate mannose Defective MAN1B1 causes MRT15 Defective ALG11 causes ALG11-CDG (CDG-1p) Defective ALG2 causes ALG2-CDG (CDG-1i) Defective ALG3 causes ALG3-CDG (CDG-1d) Post-translational protein modification Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2 Synthesis of substrates in N-glycan biosythesis Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Post-translational modification: synthesis of GPI-anchored proteins Defective ALG6 causes ALG6-CDG (CDG-1c) Defective RFT1 causes RFT1-CDG (CDG-1n) Asparagine N-linked glycosylation Defective ALG8 causes ALG8-CDG (CDG-1h) Defective MPDU1 causes MPDU1-CDG (CDG-1f) Defective ALG12 causes ALG12-CDG (CDG-1g) Synthesis of dolichyl-phosphate mannose Diseases associated with N-glycosylation of proteins	Diseases of glycosylation Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS) Defective ALG1 causes ALG1-CDG (CDG-1k) Defective MGAT2 causes MGAT2-CDG (CDG-2a) Defective MOGS causes MOGS-CDG (CDG-2b) Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein Defective ALG9 causes ALG9-CDG (CDG-1l) Synthesis of dolichyl-phosphate mannose Defective MAN1B1 causes MRT15 Defective ALG11 causes ALG11-CDG (CDG-1p) Defective ALG2 causes ALG2-CDG (CDG-1i) Defective ALG3 causes ALG3-CDG (CDG-1d) Post-translational protein modification Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2 Synthesis of substrates in N-glycan biosythesis Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Post-translational modification: synthesis of GPI-anchored proteins Defective ALG6 causes ALG6-CDG (CDG-1c) Defective RFT1 causes RFT1-CDG (CDG-1n) Asparagine N-linked glycosylation Defective ALG8 causes ALG8-CDG (CDG-1h) Defective MPDU1 causes MPDU1-CDG (CDG-1f) Defective ALG12 causes ALG12-CDG (CDG-1g) Synthesis of dolichyl-phosphate mannose Diseases associated with N-glycosylation of proteins
Drugs
Diseases
GWAS			Liver enzyme levels (gamma-glutamyl transferase) ( 22001757) Prostate cancer ( 23535732)
Protein-Protein Interactions		6 interactors: DPM1 DPM3 HLA-DMB PIGA PIGC VKORC1	2 interactors: DPM1 DPM2
Entrez ID		8818	54344
HPRD ID		16028	16179
Ensembl ID		ENSG00000136908	ENSG00000179085
Uniprot IDs		O94777	Q86TM7 Q9P2X0
PDB IDs
Enriched GO Terms of Interacting Partners?		C-terminal Protein Lipidation Post-translational Protein Modification GPI Anchor Biosynthetic Process GPI Anchor Metabolic Process Glycolipid Biosynthetic Process Protein Lipidation Lipoprotein Biosynthetic Process Phosphatidylinositol Biosynthetic Process Glycolipid Metabolic Process Lipoprotein Metabolic Process Glycerophospholipid Biosynthetic Process Phosphatidylinositol Metabolic Process Membrane Lipid Metabolic Process Phospholipid Biosynthetic Process Glycerophospholipid Metabolic Process Glycerolipid Metabolic Process Phospholipid Metabolic Process Protein O-linked Mannosylation Lipid Biosynthetic Process Preassembly Of GPI Anchor In ER Membrane Protein Mannosylation Mannosylation Cellular Lipid Metabolic Process Organophosphate Metabolic Process Dolichol-linked Oligosaccharide Biosynthetic Process Lipid Metabolic Process Protein O-linked Glycosylation Cellular Protein Modification Process Positive Regulation Of T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Protein N-linked Glycosylation Via Asparagine Protein N-linked Glycosylation Dolichol Metabolic Process Cellular Protein Metabolic Process Peptidyl-amino Acid Modification Protein C-linked Glycosylation Via 2'-alpha-mannosyl-L-tryptophan Peptide Antigen Assembly With MHC Class II Protein Complex MHC Class II Protein Complex Assembly Vitamin K Metabolic Process Phosphate-containing Compound Metabolic Process Macromolecule Glycosylation Protein Glycosylation Glycosylation Protein Metabolic Process Peptidyl-glutamic Acid Carboxylation Glycoprotein Biosynthetic Process Glycoprotein Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process GDP-mannose Metabolic Process Quinone Metabolic Process	Dolichol Metabolic Process Protein O-linked Mannosylation Protein Mannosylation C-terminal Protein Lipidation Mannosylation Dolichol-linked Oligosaccharide Biosynthetic Process GPI Anchor Biosynthetic Process GPI Anchor Metabolic Process Glycolipid Biosynthetic Process Protein O-linked Glycosylation Protein N-linked Glycosylation Via Asparagine Protein Lipidation Lipoprotein Biosynthetic Process Protein N-linked Glycosylation Phosphatidylinositol Biosynthetic Process Isoprenoid Metabolic Process Glycolipid Metabolic Process Lipoprotein Metabolic Process Glycerophospholipid Biosynthetic Process Post-translational Protein Modification Phosphatidylinositol Metabolic Process Membrane Lipid Metabolic Process Phospholipid Biosynthetic Process Glycerophospholipid Metabolic Process Macromolecule Glycosylation Protein Glycosylation Alcohol Metabolic Process Glycosylation Glycerolipid Metabolic Process Phospholipid Metabolic Process Glycoprotein Biosynthetic Process Glycoprotein Metabolic Process Lipid Biosynthetic Process Preassembly Of GPI Anchor In ER Membrane Peptidyl-amino Acid Modification Cellular Lipid Metabolic Process Organophosphate Metabolic Process Carbohydrate Metabolic Process GDP-mannose Metabolic Process Lipid Metabolic Process Nucleotide-sugar Metabolic Process Small Molecule Metabolic Process Regulation Of Protein Stability Phosphate-containing Compound Metabolic Process Cellular Protein Modification Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Cellular Protein Metabolic Process Posttranscriptional Regulation Of Gene Expression
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