PCDH1 and ATF7IP

Number of citations of the paper that reports this interaction (PubMedID 15231748)
54

Data Source:
HPRD (two hybrid)

		PCDH1	ATF7IP
Description		protocadherin 1	activating transcription factor 7 interacting protein
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GO Annotations	Cellular Component	Nucleoplasm Nucleolus Plasma Membrane Cell-cell Junction Membrane Cell Junction Anchoring Junction	Nucleus Nucleoplasm Transcription Regulator Complex Cytosol Nuclear Body
	Molecular Function	Calcium Ion Binding Cell Adhesion Molecule Binding	Transcription Coregulator Activity Transcription Corepressor Activity Protein Binding ATP Hydrolysis Activity
	Biological Process	Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Cell-cell Signaling Nervous System Development	Negative Regulation Of Transcription By RNA Polymerase II DNA Methylation-dependent Constitutive Heterochromatin Formation Regulation Of DNA-templated Transcription Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription
Pathways			PKMTs methylate histone lysines Regulation of endogenous retroelements by KRAB-ZFP proteins Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex
Drugs
Diseases
GWAS		Cerebral amyloid deposition (PET imaging) ( 26252872) Lung cancer ( 28604730) Major depressive disorder ( 23377640) Myopia (pathological) ( 23406873)	Breast cancer ( 24143190) Cognitive ability (MTAG) ( 29186694) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Height ( 31562340 33713608) Household income (MTAG) ( 31844048) Intelligence (MTAG) ( 29326435) Leukocyte telomere length ( 32109421) Liver enzyme levels (alkaline phosphatase) ( 33972514) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Prostate-specific antigen levels ( 23359319) Testicular germ cell cancer ( 20543847) Testicular germ cell tumor ( 23666240 28604728 28604732)
Interacting Genes		3 interacting genes: ATF7IP SMAD3 VKORC1	71 interacting genes: A2M ACTB ACTG1 AP1B1 CADM1 CEP250 COL4A2 CREB1 CREBBP CSPG4 DISC1 DMTF1 DNM2 EHMT2 EPG5 FLNB FLT4 GMEB1 GTF2E2 GTF2F1 GTF2H1 HEYL HLA-B HMGB1 HSPG2 KIF13A KRT7 LAMA4 LAMA5 LAMC1 LUC7L2 MACF1 MBD1 MCAM MED4 MRI1 NOMO1 NPR1 PAPPA PAPPA2 PCDH1 PEX6 PIAS3 PKD1 PLEKHB2 POLR2C POLR2D POLR2G PRSS8 PSG3 QRICH1 RPS3A RRBP1 SENP3 SETDB1 SLC12A4 SMAD4 SP1 SPTBN1 SREBF2 STBD1 STRN SUMO2 SUSD1 SVEP1 TRIP12 TTC3 UBE2I ZBTB6 ZNF350 ZNF518A
Entrez ID		5097	55729
HPRD ID		04692	09811
Ensembl ID		ENSG00000156453	ENSG00000171681
Uniprot IDs		A8K0E7 B4DUA8 B4E2D8 Q08174	B3KNI7 B3KQF8 Q6VMQ6
PDB IDs		6BX7 6MGA 6PIM 6VFP	2RPQ
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Transforming Growth Factor Beta3 Production Negative Regulation Of Lung Blood Pressure Nuclear Mineralocorticoid Receptor Binding Peptidyl-glutamic Acid Carboxylation Oxidoreductase Activity, Acting On CH Or CH2 Groups, Disulfide As Acceptor Vitamin-K-epoxide Reductase (warfarin-insensitive) Activity Vitamin-K-epoxide Reductase (warfarin-sensitive) Activity Sterol Response Element Binding Paraxial Mesoderm Morphogenesis Transcription Regulator Complex Regulation Of Lung Blood Pressure Mesoderm Morphogenesis Immune System Development Transdifferentiation SMAD Protein Complex Pericardium Development DEAD/H-box RNA Helicase Binding Heteromeric SMAD Protein Complex Trophoblast Cell Migration Regulation Of Transforming Growth Factor Beta2 Production DNA-binding Transcription Repressor Activity Transforming Growth Factor Beta Receptor Binding Osteoblast Development Negative Regulation Of Osteoblast Proliferation Co-SMAD Binding Nuclear Glucocorticoid Receptor Binding Negative Regulation Of Cardiac Muscle Hypertrophy In Response To Stress I-SMAD Binding Nodal Signaling Pathway Negative Regulation Of Cytosolic Calcium Ion Concentration Lens Fiber Cell Differentiation Positive Regulation Of Extracellular Matrix Assembly Primary MiRNA Processing Embryonic Foregut Morphogenesis Quinone Binding Peptidyl-glutamic Acid Modification Vitamin K Metabolic Process Positive Regulation Of Transforming Growth Factor Beta Production Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Positive Regulation Of Chondrocyte Differentiation Regulation Of Osteoblast Proliferation Negative Regulation Of MiRNA Transcription Positive Regulation Of Positive Chemotaxis Embryonic Cranial Skeleton Morphogenesis Positive Regulation Of Extracellular Matrix Organization Regulation Of Extracellular Matrix Assembly Thyroid Gland Development SMAD Protein Signal Transduction BHLH Transcription Factor Binding Positive Regulation Of Focal Adhesion Assembly	Transcription By RNA Polymerase II DNA-templated Transcription Morphogenesis Of A Polarized Epithelium Transcription Initiation At RNA Polymerase II Promoter Nucleoplasm DNA-templated Transcription Initiation Basement Membrane Laminin-11 Complex Laminin-10 Complex Lymph Vessel Morphogenesis RNA Polymerase II, Core Complex Nucleobase-containing Compound Biosynthetic Process SUMO Transferase Activity Regulation Of Transepithelial Transport Dense Body Regulation Of Multicellular Organismal Development Nuclear Thyroid Hormone Receptor Binding Presynaptic Cytosol Macromolecule Biosynthetic Process Postsynaptic Cytosol Structural Constituent Of Postsynaptic Actin Cytoskeleton Maintenance Of Blood-brain Barrier Proximal Tubule Development Focal Adhesion DNA-directed RNA Polymerase Complex Golgi To Plasma Membrane Protein Transport Histone H3K9me2 Methyltransferase Activity DNA Methylation-dependent Constitutive Heterochromatin Formation Extracellular Exosome Positive Regulation Of Endothelial Cell Proliferation Regulation Of Transcription By RNA Polymerase II Histone H3K9 Methyltransferase Activity Nucleus
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