PCDH1 and VKORC1

Number of citations of the paper that reports this interaction (PubMedID 21103663)
0

Data Source:
BioGRID (two hybrid)

		PCDH1	VKORC1
Description		protocadherin 1	vitamin K epoxide reductase complex subunit 1
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GO Annotations	Cellular Component	Nucleoplasm Nucleolus Plasma Membrane Cell-cell Junction Membrane Cell Junction Anchoring Junction	Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Calcium Ion Binding Cell Adhesion Molecule Binding	Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On CH Or CH2 Groups, Disulfide As Acceptor Vitamin-K-epoxide Reductase (warfarin-sensitive) Activity Vitamin-K-epoxide Reductase (warfarin-insensitive) Activity Quinone Binding
	Biological Process	Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Cell-cell Signaling Nervous System Development	Xenobiotic Metabolic Process Blood Coagulation Peptidyl-glutamic Acid Carboxylation Vitamin K Metabolic Process Positive Regulation Of Coagulation Bone Development
Pathways			Metabolism of vitamin K
Drugs			Menadione Dicoumarol Phenindione Warfarin Phenprocoumon Acenocoumarol
Diseases			Combined deficiency of vitamin K-dependent clotting factors (VKCFD)
GWAS		Cerebral amyloid deposition (PET imaging) ( 26252872) Lung cancer ( 28604730) Major depressive disorder ( 23377640) Myopia (pathological) ( 23406873)	Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Body fat distribution (arm fat ratio) ( 30664634) Warfarin maintenance dose ( 18535201 19300499 20833655 26265036) Warfarin maintenance dose (adjusted for clinical factors) ( 28686080)
Interacting Genes		3 interacting genes: ATF7IP SMAD3 VKORC1	93 interacting genes: AHSG APLP2 APOA1 APOA2 APOC1 APOC3 APOC4 ARL6IP5 ASGR1 ASGR2 ATP5MC3 ATP6AP2 BCAP31 C1S CCDC12 CCDC167 CD63 CD81 CD9 CLDN10 CNN3 COMT CPLX4 CREB3 CREB3L1 CXADR DPM2 ECHDC1 FAM209A FAM210B FGG FGL1 FIS1 FTL GJB1 GORAB GPR152 HAMP HDAC6 HOMER2 HP HPR HSD17B7 IFITM3 JAGN1 KCNK17 LIG4 LMNA MANBAL MSMO1 MSRB1 MT1X MUC1 PCDH1 PCMT1 PDIA6 PIGH PLP2 PPA2 PPIB PROCR REEP5 RMDN1 RMDN3 RMND5A SAA1 SAT1 SERPINA1 SLC15A3 SLC22A2 SLC25A1 SLC31A2 SLC7A14 SNORA12 SPTSSA STAT6 SURF4 TF TMBIM4 TMEM120A TMEM134 TMEM176A TMEM230 TMEM242 TMEM256 TMEM35B TMEM45B TMT1B TRAM1 TREX1 VAPB YIF1A ZCCHC24
Entrez ID		5097	79001
HPRD ID		04692	10540
Ensembl ID		ENSG00000156453	ENSG00000167397
Uniprot IDs		A8K0E7 B4DUA8 B4E2D8 Q08174	A0A0S2Z5X7 A0A0S2Z6I4 Q9BQB6
PDB IDs		6BX7 6MGA 6PIM 6VFP	6WV3 6WV4 6WV5 6WV6 6WV7 6WVH
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Transforming Growth Factor Beta3 Production Negative Regulation Of Lung Blood Pressure Nuclear Mineralocorticoid Receptor Binding Peptidyl-glutamic Acid Carboxylation Oxidoreductase Activity, Acting On CH Or CH2 Groups, Disulfide As Acceptor Vitamin-K-epoxide Reductase (warfarin-insensitive) Activity Vitamin-K-epoxide Reductase (warfarin-sensitive) Activity Sterol Response Element Binding Paraxial Mesoderm Morphogenesis Transcription Regulator Complex Regulation Of Lung Blood Pressure Mesoderm Morphogenesis Immune System Development Transdifferentiation SMAD Protein Complex Pericardium Development DEAD/H-box RNA Helicase Binding Heteromeric SMAD Protein Complex Trophoblast Cell Migration Regulation Of Transforming Growth Factor Beta2 Production DNA-binding Transcription Repressor Activity Transforming Growth Factor Beta Receptor Binding Osteoblast Development Negative Regulation Of Osteoblast Proliferation Co-SMAD Binding Nuclear Glucocorticoid Receptor Binding Negative Regulation Of Cardiac Muscle Hypertrophy In Response To Stress I-SMAD Binding Nodal Signaling Pathway Negative Regulation Of Cytosolic Calcium Ion Concentration Lens Fiber Cell Differentiation Positive Regulation Of Extracellular Matrix Assembly Primary MiRNA Processing Embryonic Foregut Morphogenesis Quinone Binding Peptidyl-glutamic Acid Modification Vitamin K Metabolic Process Positive Regulation Of Transforming Growth Factor Beta Production Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Positive Regulation Of Chondrocyte Differentiation Regulation Of Osteoblast Proliferation Negative Regulation Of MiRNA Transcription Positive Regulation Of Positive Chemotaxis Embryonic Cranial Skeleton Morphogenesis Positive Regulation Of Extracellular Matrix Organization Regulation Of Extracellular Matrix Assembly Thyroid Gland Development SMAD Protein Signal Transduction BHLH Transcription Factor Binding Positive Regulation Of Focal Adhesion Assembly	Endoplasmic Reticulum Membrane Spherical High-density Lipoprotein Particle Very-low-density Lipoprotein Particle High-density Lipoprotein Particle High-density Lipoprotein Particle Receptor Binding Blood Microparticle Endoplasmic Reticulum Chylomicron Cholesterol Efflux Phospholipid Efflux Membrane Cholesterol Transport Phosphatidylcholine-sterol O-acyltransferase Activator Activity Negative Regulation Of Very-low-density Lipoprotein Particle Remodeling High-density Lipoprotein Particle Remodeling Sterol Transport Lipase Inhibitor Activity Plasma Lipoprotein Particle Assembly Protein-lipid Complex Assembly Plasma Lipoprotein Particle Clearance Extracellular Exosome Lipoprotein Metabolic Process Organic Hydroxy Compound Transport Asialoglycoprotein Receptor Activity Regulation Of Transport Endoplasmic Reticulum Lumen Regulation Of Intestinal Absorption Plasma Lipoprotein Particle Remodeling Response To Endoplasmic Reticulum Stress Cellular Response To Lipoprotein Particle Stimulus Protein-containing Complex Remodeling Lipid Transport Negative Regulation Of Lipid Transport Zymogen Activation Acute-phase Response Chemical Homeostasis Triglyceride Homeostasis Acylglycerol Homeostasis Peptidyl-methionine Modification Negative Regulation Of Cholesterol Import Myoblast Fusion Involved In Skeletal Muscle Regeneration Iron Ion Export Across Plasma Membrane Reverse Cholesterol Transport Regulation Of Lipid Transport Defense Response Endocytic Vesicle Lumen Cholesterol Binding Apolipoprotein Receptor Binding Negative Regulation Of Very-low-density Lipoprotein Particle Clearance Negative Regulation Of Cholesterol Transport
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