FGL1 and VKORC1

Number of citations of the paper that reports this interaction (PubMedID 21103663)
0

Data Source:
BioGRID (two hybrid)

		FGL1	VKORC1
Description		fibrinogen like 1	vitamin K epoxide reductase complex subunit 1
Image
GO Annotations	Cellular Component	Extracellular Region Fibrinogen Complex Extracellular Space Extracellular Matrix	Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Protein Binding	Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On CH Or CH2 Groups, Disulfide As Acceptor Vitamin-K-epoxide Reductase (warfarin-sensitive) Activity Vitamin-K-epoxide Reductase (warfarin-insensitive) Activity Quinone Binding
	Biological Process	Adaptive Immune Response Immune System Process Blood Coagulation Regulation Of Immune Response Negative Regulation Of T Cell Activation Hepatocyte Proliferation	Xenobiotic Metabolic Process Blood Coagulation Peptidyl-glutamic Acid Carboxylation Vitamin K Metabolic Process Positive Regulation Of Coagulation Bone Development
Pathways			Metabolism of vitamin K
Drugs			Menadione Dicoumarol Phenindione Warfarin Phenprocoumon Acenocoumarol
Diseases			Combined deficiency of vitamin K-dependent clotting factors (VKCFD)
GWAS		Blood protein levels ( 30072576) Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) ( 26503814)	Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Body fat distribution (arm fat ratio) ( 30664634) Warfarin maintenance dose ( 18535201 19300499 20833655 26265036) Warfarin maintenance dose (adjusted for clinical factors) ( 28686080)
Interacting Genes		3 interacting genes: BCL2L11 GLP1R VKORC1	93 interacting genes: AHSG APLP2 APOA1 APOA2 APOC1 APOC3 APOC4 ARL6IP5 ASGR1 ASGR2 ATP5MC3 ATP6AP2 BCAP31 C1S CCDC12 CCDC167 CD63 CD81 CD9 CLDN10 CNN3 COMT CPLX4 CREB3 CREB3L1 CXADR DPM2 ECHDC1 FAM209A FAM210B FGG FGL1 FIS1 FTL GJB1 GORAB GPR152 HAMP HDAC6 HOMER2 HP HPR HSD17B7 IFITM3 JAGN1 KCNK17 LIG4 LMNA MANBAL MSMO1 MSRB1 MT1X MUC1 PCDH1 PCMT1 PDIA6 PIGH PLP2 PPA2 PPIB PROCR REEP5 RMDN1 RMDN3 RMND5A SAA1 SAT1 SERPINA1 SLC15A3 SLC22A2 SLC25A1 SLC31A2 SLC7A14 SNORA12 SPTSSA STAT6 SURF4 TF TMBIM4 TMEM120A TMEM134 TMEM176A TMEM230 TMEM242 TMEM256 TMEM35B TMEM45B TMT1B TRAM1 TREX1 VAPB YIF1A ZCCHC24
Entrez ID		2267	79001
HPRD ID		09312	10540
Ensembl ID		ENSG00000104760	ENSG00000167397
Uniprot IDs		Q08830	A0A0S2Z5X7 A0A0S2Z6I4 Q9BQB6
PDB IDs		7TZ2	6WV3 6WV4 6WV5 6WV6 6WV7 6WVH
Enriched GO Terms of Interacting Partners?		Glucagon-like Peptide 1 Receptor Activity BIM-BCL-2 Complex BIM-BCL-xl Complex Peptidyl-glutamic Acid Carboxylation Oxidoreductase Activity, Acting On CH Or CH2 Groups, Disulfide As Acceptor Vitamin-K-epoxide Reductase (warfarin-insensitive) Activity Vitamin-K-epoxide Reductase (warfarin-sensitive) Activity Glucagon Receptor Activity Apoptotic Process Involved In Embryonic Digit Morphogenesis Response To Psychosocial Stress Post-translational Protein Targeting To Membrane, Translocation Cellular Response To Glucagon Stimulus Activation Of Adenylate Cyclase Activity Cellular Response To Hormone Stimulus Positive Regulation Of Fibroblast Apoptotic Process Positive Regulation Of Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Ear Development Regulation Of Developmental Pigmentation Positive Regulation Of T Cell Apoptotic Process Bcl-2 Family Protein Complex Positive Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Positive Regulation Of IRE1-mediated Unfolded Protein Response Thymocyte Apoptotic Process Developmental Pigmentation Quinone Binding Peptidyl-glutamic Acid Modification Vitamin K Metabolic Process Positive Regulation Of Lyase Activity Regulation Of Biological Quality Positive Regulation Of Adenylate Cyclase Activity Response To Glucagon Regulation Of Fibroblast Apoptotic Process Regulation Of IRE1-mediated Unfolded Protein Response Mitochondrial Outer Membrane Permeabilization Involved In Programmed Cell Death Positive Regulation Of Lymphocyte Apoptotic Process Positive Regulation Of Cyclase Activity Response To Hormone Apoptotic Process Involved In Morphogenesis Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Intracellular Protein Transmembrane Transport Regulation Of Multicellular Organismal Process Positive Regulation Of Blood Pressure B Cell Homeostasis T Cell Apoptotic Process Positive Regulation Of Membrane Permeability Positive Regulation Of Mitochondrial Membrane Permeability Positive Regulation Of Release Of Cytochrome C From Mitochondria Positive Regulation Of Leukocyte Apoptotic Process Myeloid Cell Homeostasis	Endoplasmic Reticulum Membrane Spherical High-density Lipoprotein Particle Very-low-density Lipoprotein Particle High-density Lipoprotein Particle High-density Lipoprotein Particle Receptor Binding Blood Microparticle Endoplasmic Reticulum Chylomicron Cholesterol Efflux Phospholipid Efflux Membrane Cholesterol Transport Phosphatidylcholine-sterol O-acyltransferase Activator Activity Negative Regulation Of Very-low-density Lipoprotein Particle Remodeling High-density Lipoprotein Particle Remodeling Sterol Transport Lipase Inhibitor Activity Plasma Lipoprotein Particle Assembly Protein-lipid Complex Assembly Plasma Lipoprotein Particle Clearance Extracellular Exosome Lipoprotein Metabolic Process Organic Hydroxy Compound Transport Asialoglycoprotein Receptor Activity Regulation Of Transport Endoplasmic Reticulum Lumen Regulation Of Intestinal Absorption Plasma Lipoprotein Particle Remodeling Response To Endoplasmic Reticulum Stress Cellular Response To Lipoprotein Particle Stimulus Protein-containing Complex Remodeling Lipid Transport Negative Regulation Of Lipid Transport Zymogen Activation Acute-phase Response Chemical Homeostasis Triglyceride Homeostasis Acylglycerol Homeostasis Peptidyl-methionine Modification Negative Regulation Of Cholesterol Import Myoblast Fusion Involved In Skeletal Muscle Regeneration Iron Ion Export Across Plasma Membrane Reverse Cholesterol Transport Regulation Of Lipid Transport Defense Response Endocytic Vesicle Lumen Cholesterol Binding Apolipoprotein Receptor Binding Negative Regulation Of Very-low-density Lipoprotein Particle Clearance Negative Regulation Of Cholesterol Transport
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