ATP6AP2 and TMEM203

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ATP6AP2	TMEM203
Description		ATPase H+ transporting accessory protein 2	transmembrane protein 203
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Vacuolar Proton-transporting V-type ATPase, V0 Domain Autophagosome Membrane Cytoplasm Lysosome Lysosomal Membrane Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane External Side Of Plasma Membrane Endosome Membrane Membrane Vacuolar Proton-transporting V-type ATPase Complex Axon Clathrin-coated Vesicle Membrane Synaptic Vesicle Membrane Cytoplasmic Vesicle Dendritic Spine Membrane Proton-transporting V-type ATPase Complex Cell Projection Synapse Postsynaptic Membrane Extracellular Exosome Tertiary Granule Membrane Bounding Membrane Of Organelle Ficolin-1-rich Granule Membrane	Lysosome Lysosomal Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane
	Molecular Function	Protein Binding Signaling Receptor Activity	Protein Binding
	Biological Process	Angiotensin Maturation Vacuolar Acidification Lysosomal Lumen Acidification Central Nervous System Maturation Rostrocaudal Neural Tube Patterning Positive Regulation Of Wnt Signaling Pathway Positive Regulation Of Transforming Growth Factor Beta1 Production Regulation Of MAPK Cascade Eye Pigmentation Endosomal Lumen Acidification Intracellular PH Reduction Head Morphogenesis Golgi Lumen Acidification Positive Regulation Of Canonical Wnt Signaling Pathway Synaptic Vesicle Lumen Acidification Proton Transmembrane Transport	Intracellular Calcium Ion Homeostasis Spermatogenesis
Pathways		Metabolism of Angiotensinogen to Angiotensins Neutrophil degranulation
Drugs
Diseases		Syndromic X-linked mental retardation with epilepsy or seizures, including: West syndrome (WS); Partington syndrome (PRTS); Proud syndrome (ACCAG); XMR and epilepsy (XMRE); MRXHF1; XMR OPHN1-related (MRXSO) ; XELBD; XMR, Christianson type (MRXSC); Creatine deficiency syndrome (XL-CDS); Renpenning syndrome (RENS1); Epilepsy and mental retardation limited to females (EFMR); Periventricular nodular heterotopia (PVNH); Hydrocephalus (XLH); XMR, JARID1C related (MRXSJ); Boerjeson-Forssman syndrome (BFLS); CK syndrome (CKS)
GWAS		Metabolite levels ( 23823483)
Interacting Genes		20 interacting genes: ADRA1A AGT CD72 CREB3 GLP1R HTR2C NINJ1 NKG7 NSG1 PMP22 PTTG1IP REN SEC22A TIMMDC1 TMEM203 TMEM97 UPK2 VAMP5 VKORC1 ZBTB16	41 interacting genes: ANK1 AQP6 ATP6AP2 CD3G CNR2 CPLX4 CREB3 CREB3L1 EBP ELOVL4 ERGIC3 FAM174A FAM209A FFAR2 GPX8 HSD17B11 HSD17B13 KCNJ6 LMNA LY6G6C MANBAL MMD PDZK1IP1 RETREG3 RMDN3 RNASEK SCN3B SLC10A6 SLC18A1 SLC61A1 SSMEM1 STOM STX4 TIMMDC1 TMEM14B TMEM234 TMEM31 TMEM52B TMEM60 TMEM86B TMX2
Entrez ID		10159	94107
HPRD ID		06454	17496
Ensembl ID		ENSG00000182220	ENSG00000187713
Uniprot IDs		O75787	Q969S6
PDB IDs		3LBS 3LC8 6WLW 6WM2 6WM3 6WM4 7U4T
Enriched GO Terms of Interacting Partners?		Type 2 Angiotensin Receptor Binding Renin-angiotensin Regulation Of Aldosterone Production Membrane Maintenance Of Blood Vessel Diameter Homeostasis By Renin-angiotensin Regulation Of Blood Volume By Renin-angiotensin Establishment Of Protein Localization To Plasma Membrane Regulation Of Blood Pressure Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Mesonephros Development Angiotensin-activated Signaling Pathway Renal System Process Involved In Regulation Of Systemic Arterial Blood Pressure Protein Transport Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Hormone Levels Cell-cell Signaling Blood Vessel Diameter Maintenance Vasoconstriction Positive Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Heart Rate Involved In Baroreceptor Response To Increased Systemic Arterial Blood Pressure Cell Communication Regulation Of Tube Size Regulation Of System Process Signaling CGMP-mediated Signaling Kidney Development Regulation Of Lipid Transport Regulation Of Systemic Arterial Blood Pressure Mediated By A Chemical Signal Golgi To Plasma Membrane Protein Transport Vesicle-mediated Transport To The Plasma Membrane Intracellular Protein Localization Establishment Of Protein Localization Glucagon-like Peptide 1 Receptor Activity Regulation Of Monocyte Chemotaxis Ferroptosis Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Positive Regulation Of Deacetylase Activity Postsynaptic Neurotransmitter Receptor Cycle Neurotransmitter Receptor Cycle Vitamin-K-epoxide Reductase (warfarin-insensitive) Activity Positive Regulation Of Inflammatory Response Animal Organ Development Regulation Of Systemic Arterial Blood Pressure Signaling Receptor Binding Protein Localization To Plasma Membrane Regulation Of Heart Contraction Positive Regulation Of The Force Of Heart Contraction By Epinephrine-norepinephrine Positive Regulation Of Heart Rate By Epinephrine-norepinephrine Phospholipase C-activating Adrenergic Receptor Signaling Pathway Norepinephrine-epinephrine Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger	Membrane Endoplasmic Reticulum Steroid Dehydrogenase Activity Protein Binding Endoplasmic Reticulum Membrane Golgi Lumen Acidification Vacuolar Proton-transporting V-type ATPase, V0 Domain
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