ATP6AP2 and REN

Number of citations of the paper that reports this interaction (PubMedID 12045255)
40

Data Source:
HPRD (in vivo, in vitro)

		ATP6AP2	REN
Description		ATPase H+ transporting accessory protein 2	renin
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GO Annotations	Cellular Component	Golgi Membrane Vacuolar Proton-transporting V-type ATPase, V0 Domain Autophagosome Membrane Cytoplasm Lysosome Lysosomal Membrane Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane External Side Of Plasma Membrane Endosome Membrane Membrane Vacuolar Proton-transporting V-type ATPase Complex Axon Clathrin-coated Vesicle Membrane Synaptic Vesicle Membrane Cytoplasmic Vesicle Dendritic Spine Membrane Proton-transporting V-type ATPase Complex Cell Projection Synapse Postsynaptic Membrane Extracellular Exosome Tertiary Granule Membrane Bounding Membrane Of Organelle Ficolin-1-rich Granule Membrane	Extracellular Region Extracellular Space Plasma Membrane Membrane Apical Part Of Cell
	Molecular Function	Protein Binding Signaling Receptor Activity	Endopeptidase Activity Aspartic-type Endopeptidase Activity Signaling Receptor Binding Insulin-like Growth Factor Receptor Binding Protein Binding Peptidase Activity Hydrolase Activity
	Biological Process	Angiotensin Maturation Vacuolar Acidification Lysosomal Lumen Acidification Central Nervous System Maturation Rostrocaudal Neural Tube Patterning Positive Regulation Of Wnt Signaling Pathway Positive Regulation Of Transforming Growth Factor Beta1 Production Regulation Of MAPK Cascade Eye Pigmentation Endosomal Lumen Acidification Intracellular PH Reduction Head Morphogenesis Golgi Lumen Acidification Positive Regulation Of Canonical Wnt Signaling Pathway Synaptic Vesicle Lumen Acidification Proton Transmembrane Transport	Kidney Development Mesonephros Development Angiotensin Maturation Regulation Of Blood Volume By Renin-angiotensin Renin-angiotensin Regulation Of Aldosterone Production Maintenance Of Blood Vessel Diameter Homeostasis By Renin-angiotensin Proteolysis Regulation Of Blood Pressure Male Gonad Development Response To Xenobiotic Stimulus Hormone-mediated Signaling Pathway Gene Expression Response To Lipopolysaccharide Response To Immobilization Stress Angiotensin-activated Signaling Pathway Drinking Behavior Regulation Of MAPK Cascade Cell Maturation Amyloid-beta Metabolic Process Response To CAMP Response To CGMP Cellular Response To Xenobiotic Stimulus Juxtaglomerular Apparatus Development
Pathways		Metabolism of Angiotensinogen to Angiotensins Neutrophil degranulation	Metabolism of Angiotensinogen to Angiotensins
Drugs			Remikiren Minoxidil Lisinopril N,N-dimethylformamide Isoamyl alcohol 3-Phenyl-1,2-Propandiol 2-Methyl-3-(2-Aminothiazolo)Propanal Enalkiren 2-Cyclopropylmethylenepropanal 1-Methyl-2-Oxy-5,5-Dimethyl Pyrrolidine N-Methyl-N-(Methylbenzyl)Formamide 1-Hydroxy-2-Amino-3-Cyclohexylpropane SPP1148 N-{2-[6-(2,4-DIAMINO-6-ETHYLPYRIMIDIN-5-YL)-2,2-DIMETHYL-3-OXO-2,3-DIHYDRO-4H-1,4-BENZOTHIAZIN-4-YL]ETHYL}ACETAMIDE 6-ETHYL-5-[9-(3-METHOXYPROPYL)-9H-CARBAZOL-2-YL]PYRIMIDINE-2,4-DIAMINE N-{2-[6-(2,4-DIAMINO-6-ETHYLPYRIMIDIN-5-YL)-2,2-DIMETHYL-3-OXO-2,3-DIHYDRO-4H-1,4-BENZOXAZIN-4-YL]ETHYL}ACETAMIDE (2S)-6-(2,4-DIAMINO-6-ETHYLPYRIMIDIN-5-YL)-2-(3,5-DIFLUOROPHENYL)-4-(3-METHOXYPROPYL)-2H-1,4-BENZOXAZIN-3(4H)-ONE 6-(2,4-DIAMINO-6-ETHYLPYRIMIDIN-5-YL)-4-(3-METHOXYPROPYL)-2,2-DIMETHYL-2H-1,4-BENZOXAZIN-3(4H)-ONE 5-{4-[(3,5-DIFLUOROBENZYL)AMINO]PHENYL}-6-ETHYLPYRIMIDINE-2,4-DIAMINE 6-ethyl-5-[(2S)-1-(3-methoxypropyl)-2-phenyl-1,2,3,4-tetrahydroquinolin-7-yl]pyrimidine-2,4-diamine Aliskiren
Diseases		Syndromic X-linked mental retardation with epilepsy or seizures, including: West syndrome (WS); Partington syndrome (PRTS); Proud syndrome (ACCAG); XMR and epilepsy (XMRE); MRXHF1; XMR OPHN1-related (MRXSO) ; XELBD; XMR, Christianson type (MRXSC); Creatine deficiency syndrome (XL-CDS); Renpenning syndrome (RENS1); Epilepsy and mental retardation limited to females (EFMR); Periventricular nodular heterotopia (PVNH); Hydrocephalus (XLH); XMR, JARID1C related (MRXSJ); Boerjeson-Forssman syndrome (BFLS); CK syndrome (CKS)	Uromodulin-associated kidney diseases, including: Medullary cystic kidney disease 2; Familial juvenile hyperuremic nephropathy; Glomerulocystic kidney disease Renal tubular dysgenesis
GWAS		Metabolite levels ( 23823483)	Blood protein levels in cardiovascular risk ( 28369058) Response to cognitive-behavioural therapy in anxiety disorder ( 31123309)
Interacting Genes		20 interacting genes: ADRA1A AGT CD72 CREB3 GLP1R HTR2C NINJ1 NKG7 NSG1 PMP22 PTTG1IP REN SEC22A TIMMDC1 TMEM203 TMEM97 UPK2 VAMP5 VKORC1 ZBTB16	9 interacting genes: AGT ATP6AP2 CCDC24 CTSB KCTD15 M6PR PCSK1 PCSK5 RENBP
Entrez ID		10159	5972
HPRD ID		06454	01564
Ensembl ID		ENSG00000182220	ENSG00000143839
Uniprot IDs		O75787	P00797
PDB IDs		3LBS 3LC8 6WLW 6WM2 6WM3 6WM4 7U4T	1BBS 1BIL 1BIM 1HRN 1RNE 2BKS 2BKT 2FS4 2G1N 2G1O 2G1R 2G1S 2G1Y 2G20 2G21 2G22 2G24 2G26 2G27 2I4Q 2IKO 2IKU 2IL2 2REN 2V0Z 2V10 2V11 2V12 2V13 2V16 2X0B 3D91 3G6Z 3G70 3G72 3GW5 3K1W 3KM4 3O9L 3OAD 3OAG 3OOT 3OQF 3OQK 3OWN 3Q3T 3Q4B 3Q5H 3SFC 3VCM 3VSW 3VSX 3VUC 3VYD 3VYE 3VYF 4AMT 4GJ5 4GJ6 4GJ7 4GJ8 4GJ9 4GJA 4GJB 4GJC 4GJD 4PYV 4Q1N 4RYC 4RYG 4RZ1 4S1G 4XX3 4XX4 5KOQ 5KOS 5KOT 5SXN 5SY2 5SY3 5SZ9 5T4S 5TMG 5TMK 5V8V 5VPM 5VRP 6I3F 7XGK 7XGO 7XGP
Enriched GO Terms of Interacting Partners?		Type 2 Angiotensin Receptor Binding Renin-angiotensin Regulation Of Aldosterone Production Membrane Maintenance Of Blood Vessel Diameter Homeostasis By Renin-angiotensin Regulation Of Blood Volume By Renin-angiotensin Establishment Of Protein Localization To Plasma Membrane Regulation Of Blood Pressure Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Mesonephros Development Angiotensin-activated Signaling Pathway Renal System Process Involved In Regulation Of Systemic Arterial Blood Pressure Protein Transport Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Hormone Levels Cell-cell Signaling Blood Vessel Diameter Maintenance Vasoconstriction Positive Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Heart Rate Involved In Baroreceptor Response To Increased Systemic Arterial Blood Pressure Cell Communication Regulation Of Tube Size Regulation Of System Process Signaling CGMP-mediated Signaling Kidney Development Regulation Of Lipid Transport Regulation Of Systemic Arterial Blood Pressure Mediated By A Chemical Signal Golgi To Plasma Membrane Protein Transport Vesicle-mediated Transport To The Plasma Membrane Intracellular Protein Localization Establishment Of Protein Localization Glucagon-like Peptide 1 Receptor Activity Regulation Of Monocyte Chemotaxis Ferroptosis Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Positive Regulation Of Deacetylase Activity Postsynaptic Neurotransmitter Receptor Cycle Neurotransmitter Receptor Cycle Vitamin-K-epoxide Reductase (warfarin-insensitive) Activity Positive Regulation Of Inflammatory Response Animal Organ Development Regulation Of Systemic Arterial Blood Pressure Signaling Receptor Binding Protein Localization To Plasma Membrane Regulation Of Heart Contraction Positive Regulation Of The Force Of Heart Contraction By Epinephrine-norepinephrine Positive Regulation Of Heart Rate By Epinephrine-norepinephrine Phospholipase C-activating Adrenergic Receptor Signaling Pathway Norepinephrine-epinephrine Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger	Peptide Hormone Processing Signaling Receptor Ligand Precursor Processing Hormone Metabolic Process Regulation Of Hormone Levels Endopeptidase Activity Peptide Biosynthetic Process Protein Processing Proteolysis Plasma Lipoprotein Particle Remodeling Protein-containing Complex Remodeling Peptide Metabolic Process Protein Maturation N-acylglucosamine 2-epimerase Activity Eye Pigmentation Regulation Of Biological Quality Positive Regulation Of Membrane Hyperpolarization G Protein-coupled Receptor Signaling Pathway Coupled To CGMP Nucleotide Second Messenger Type 2 Angiotensin Receptor Binding N-acetylmannosamine Metabolic Process Central Nervous System Maturation Transport Vesicle Positive Regulation Of Angiotensin-activated Signaling Pathway Renin-angiotensin Regulation Of Aldosterone Production Response To Muscle Activity Involved In Regulation Of Muscle Adaptation Regulation Of Renal Output By Angiotensin Peptidase Activity Rostrocaudal Neural Tube Patterning Lysosome Protein Secretion Establishment Of Protein Localization To Extracellular Region Protein Localization To Extracellular Region Serine-type Peptidase Activity Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway Peptidase Inhibitor Complex Viral Life Cycle Renin Secretion Into Blood Stream Regulation Of Membrane Hyperpolarization Type 1 Angiotensin Receptor Binding Regulation Of Angiotensin-activated Signaling Pathway Maintenance Of Blood Vessel Diameter Homeostasis By Renin-angiotensin Endolysosome Lumen Secretion Of Lysosomal Enzymes Cytokine Precursor Processing Serine-type Endopeptidase Activity Cell-cell Signaling Regulation Of Blood Volume By Renin-angiotensin Positive Regulation Of Gap Junction Assembly Anterior/posterior Pattern Specification N-acetylneuraminate Catabolic Process Positive Regulation Of Transforming Growth Factor Beta1 Production
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