MYD88 and IL1RAP

Number of citations of the paper that reports this interaction (PMID 11544529)
199

Data Source:
BioGRID (genetic interference)
HPRD (in vivo)

		MYD88	IL1RAP
Gene Name		myeloid differentiation primary response 88	interleukin 1 receptor accessory protein
Image
Gene Ontology Annotations	Cellular Component	Cytosol Plasma Membrane Endosome Membrane	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane Membrane
	Molecular Function	Death Receptor Binding Protein Binding Identical Protein Binding TIR Domain Binding	Signal Transducer Activity Interleukin-1 Receptor Activity
	Biological Process	Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Inflammatory Response Signal Transduction Cell Surface Receptor Signaling Pathway Positive Regulation Of Type I Interferon Production Positive Regulation Of Interleukin-17 Production Positive Regulation Of Interleukin-23 Production Positive Regulation Of Interleukin-6 Production Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Negative Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Neurotrophin TRK Receptor Signaling Pathway Regulation Of Inflammatory Response Defense Response To Gram-positive Bacterium Response To Interleukin-1 3'-UTR-mediated MRNA Stabilization Cellular Response To Mechanical Stimulus	Protein Complex Assembly Inflammatory Response Immune Response Cytokine-mediated Signaling Pathway Interleukin-2 Biosynthetic Process Innate Immune Response
Pathways		p75NTR recruits signalling complexes Toll Like Receptor 7/8 (TLR7/8) Cascade RIP-mediated NFkB activation via ZBP1 Toll Like Receptor TLR6:TLR2 Cascade DEx/H-box helicases activate type I IFN and inflammatory cytokines production Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade ZBP1(DAI) mediated induction of type I IFNs p75NTR signals via NF-kB MyD88 dependent cascade initiated on endosome MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Toll Like Receptor 9 (TLR9) Cascade Innate Immune System Signalling by NGF TRIF-mediated TLR3/TLR4 signaling Cytosolic sensors of pathogen-associated DNA Cytokine Signaling in Immune system p75 NTR receptor-mediated signalling MyD88-independent cascade Toll Like Receptor 2 (TLR2) Cascade RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Signaling by Interleukins Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade TRAF6 mediated IRF7 activation TRAF6 mediated NF-kB activation Interleukin-1 signaling TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling TAK1 activates NFkB by phosphorylation and activation of IKKs complex
Drugs
Diseases
GWAS			Lung cancer ( 18385676) Waist circumference ( 20966902)
Protein-Protein Interactions		39 interactors: BTK CD93 CISH FADD FLII IL1R1 IL1RAP IL1RL1 IRAK1 IRAK2 IRAK3 IRAK4 IRF4 IRF5 IRF7 MAL MBIP MDM2 PELI2 PFKL POLR1C PRDX1 RAC1 SARM1 SIAH1 SIAH2 SMAD3 SPOP STAP2 TIRAP TLR10 TLR2 TLR3 TLR4 TLR5 TLR7 TLR8 TXN USP7	19 interactors: CCNI IL18R1 IL1A IL1B IL1R1 IL1R2 IRAK1 KPNA1 MARCH8 MC4R MYD88 PIK3R1 PRKCI PRPF40A RAC1 SIRPA STAT3 TICAM2 TOLLIP
Entrez ID		4615	3556
HPRD ID		03703	04021
Ensembl ID		ENSG00000172936	ENSG00000196083
Uniprot IDs		J3KPU4 J3KQ87 J3KQJ6 Q99836	A8K6K4 Q9NPH3
PDB IDs		2JS7 2Z5V 3MOP 4DOM 4EO7	3O4O 4DEP
Enriched GO Terms of Interacting Partners?		Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Positive Regulation Of Innate Immune Response Innate Immune Response Immune Response MyD88-dependent Toll-like Receptor Signaling Pathway Regulation Of Innate Immune Response Immune Response-regulating Signaling Pathway Immune System Process Regulation Of Immune Response Toll-like Receptor 4 Signaling Pathway Defense Response Regulation Of Cytokine Production Positive Regulation Of Immune Response Regulation Of Immune System Process Positive Regulation Of Immune System Process Positive Regulation Of Interleukin-8 Production Positive Regulation Of Cytokine Production Regulation Of Interferon-beta Production Response To Other Organism I-kappaB Kinase/NF-kappaB Signaling Regulation Of Signaling Regulation Of Signal Transduction Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Response To Biotic Stimulus Toll-like Receptor 2 Signaling Pathway Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Type I Interferon Production Regulation Of Toll-like Receptor Signaling Pathway Response To Stress Positive Regulation Of Interferon-beta Production Regulation Of Intracellular Signal Transduction Response To External Stimulus Inflammatory Response Response To Organic Substance Positive Regulation Of Signal Transduction Positive Regulation Of Cytokine Biosynthetic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Chemokine Production Positive Regulation Of Type I Interferon Production Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Interferon-alpha Production Regulation Of Protein Metabolic Process Signal Transduction Response To Stimulus Regulation Of Chemokine Production	Response To Cytokine Cytokine-mediated Signaling Pathway Cellular Response To Organic Substance Response To Organic Substance Cellular Response To Cytokine Stimulus Immune System Process Immune Response Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Regulation Of I-kappaB Kinase/NF-kappaB Signaling Inflammatory Response Cell Surface Receptor Signaling Pathway Regulation Of Cytokine Production Positive Regulation Of Signal Transduction Signal Transduction Positive Regulation Of Cytokine Production Defense Response Response To Interleukin-1 Signaling Cell Communication Temperature Homeostasis Positive Regulation Of Protein Import Into Nucleus Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Intracellular Signal Transduction Response To Organonitrogen Compound Positive Regulation Of NF-kappaB Transcription Factor Activity Fever Generation Acute-phase Response Cellular Response To Growth Factor Stimulus Positive Regulation Of Transcription Factor Import Into Nucleus Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Chemokine Production Intracellular Signal Transduction Cellular Response To Stimulus Response To Growth Factor Positive Regulation Of Protein Transport Negative Regulation Of Cell Death Cellular Response To Lipopolysaccharide Positive Regulation Of Immune Response Positive Regulation Of Intracellular Protein Transport Cellular Response To Molecule Of Bacterial Origin Regulation Of Protein Import Into Nucleus Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Interferon-gamma Production Regulation Of Establishment Of Protein Localization Regulation Of Chemokine Production Heat Generation Response To Stimulus
Tagcloud ?		binet biology birc3 briefer chinese cll concurrent confounded consecutive descent diverse etiology european fludarabine frequencies germline give ighv insights lymphocytic mutated mutations notch1 persons predominately sf3b1 stratification tp53 un	36gamma 36r alarmin atopic augments camp cathelicidin ccl20 cxcl1 cxcl10 dermatitis dermatoses exacerbations il1rl2 il36g il36gamma il36r il8 ip10 keratinocytes lesional ll37 mip3a nonlesional occasional pertussis psoriasis rosacea wounding
Tagcloud (Difference) ?		binet biology birc3 briefer chinese cll concurrent confounded consecutive descent diverse etiology european fludarabine frequencies germline give ighv insights lymphocytic mutated mutations notch1 persons predominately sf3b1 stratification tp53 un	36gamma 36r alarmin atopic augments camp cathelicidin ccl20 cxcl1 cxcl10 dermatitis dermatoses exacerbations il1rl2 il36g il36gamma il36r il8 ip10 keratinocytes lesional ll37 mip3a nonlesional occasional pertussis psoriasis rosacea wounding
Tagcloud (Intersection) ?