Wiki-Pi
Answer Survey
Home
About
Help
Advanced Search
MYD88 and STAP2
Number of citations of the paper that reports this interaction (PMID
16365431
)
14
Data Source:
BioGRID
(pull down)
HPRD
(in vivo)
MYD88
STAP2
Gene Name
myeloid differentiation primary response 88
signal transducing adaptor family member 2
Image
Gene Ontology Annotations
Cellular Component
Cytosol
Plasma Membrane
Endosome Membrane
Cytoplasm
Plasma Membrane
Molecular Function
Death Receptor Binding
Protein Binding
Identical Protein Binding
TIR Domain Binding
Protein Binding
Biological Process
Toll-like Receptor Signaling Pathway
MyD88-dependent Toll-like Receptor Signaling Pathway
Inflammatory Response
Signal Transduction
Cell Surface Receptor Signaling Pathway
Positive Regulation Of Type I Interferon Production
Positive Regulation Of Interleukin-17 Production
Positive Regulation Of Interleukin-23 Production
Positive Regulation Of Interleukin-6 Production
Toll-like Receptor 2 Signaling Pathway
Toll-like Receptor 4 Signaling Pathway
Toll-like Receptor 5 Signaling Pathway
Toll-like Receptor 9 Signaling Pathway
Toll-like Receptor 10 Signaling Pathway
Toll-like Receptor TLR1:TLR2 Signaling Pathway
Toll-like Receptor TLR6:TLR2 Signaling Pathway
Negative Regulation Of Apoptotic Process
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Innate Immune Response
Neurotrophin TRK Receptor Signaling Pathway
Regulation Of Inflammatory Response
Defense Response To Gram-positive Bacterium
Response To Interleukin-1
3'-UTR-mediated MRNA Stabilization
Cellular Response To Mechanical Stimulus
Pathways
p75NTR recruits signalling complexes
Toll Like Receptor 7/8 (TLR7/8) Cascade
RIP-mediated NFkB activation via ZBP1
Toll Like Receptor TLR6:TLR2 Cascade
DEx/H-box helicases activate type I IFN and inflammatory cytokines production
Toll Like Receptor TLR1:TLR2 Cascade
Activated TLR4 signalling
MyD88 cascade initiated on plasma membrane
Toll Like Receptor 5 (TLR5) Cascade
ZBP1(DAI) mediated induction of type I IFNs
p75NTR signals via NF-kB
MyD88 dependent cascade initiated on endosome
MyD88:Mal cascade initiated on plasma membrane
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
Toll Like Receptor 9 (TLR9) Cascade
Innate Immune System
Signalling by NGF
TRIF-mediated TLR3/TLR4 signaling
Cytosolic sensors of pathogen-associated DNA
Cytokine Signaling in Immune system
p75 NTR receptor-mediated signalling
MyD88-independent cascade
Toll Like Receptor 2 (TLR2) Cascade
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
Signaling by Interleukins
Toll-Like Receptors Cascades
Toll Like Receptor 10 (TLR10) Cascade
Toll Like Receptor 4 (TLR4) Cascade
Toll Like Receptor 3 (TLR3) Cascade
TRAF6 mediated IRF7 activation
TRAF6 mediated NF-kB activation
Interleukin-1 signaling
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
Drugs
Diseases
GWAS
Protein-Protein Interactions
39 interactors:
BTK
CD93
CISH
FADD
FLII
IL1R1
IL1RAP
IL1RL1
IRAK1
IRAK2
IRAK3
IRAK4
IRF4
IRF5
IRF7
MAL
MBIP
MDM2
PELI2
PFKL
POLR1C
PRDX1
RAC1
SARM1
SIAH1
SIAH2
SMAD3
SPOP
STAP2
TIRAP
TLR10
TLR2
TLR3
TLR4
TLR5
TLR7
TLR8
TXN
USP7
13 interactors:
BMP4
CBL
CHUK
CSF1R
IKBKB
JAK2
MLH1
MYD88
PTK6
SRC
STAT3
STAT5A
STAT5B
Entrez ID
4615
55620
HPRD ID
03703
07430
Ensembl ID
ENSG00000172936
ENSG00000178078
Uniprot IDs
J3KPU4
J3KQ87
J3KQJ6
Q99836
Q9UGK3
PDB IDs
2JS7
2Z5V
3MOP
4DOM
4EO7
2EL8
Enriched GO Terms of Interacting Partners
?
Toll-like Receptor Signaling Pathway
Pattern Recognition Receptor Signaling Pathway
Innate Immune Response-activating Signal Transduction
Activation Of Innate Immune Response
Positive Regulation Of Innate Immune Response
Innate Immune Response
Immune Response
MyD88-dependent Toll-like Receptor Signaling Pathway
Regulation Of Innate Immune Response
Immune Response-regulating Signaling Pathway
Immune System Process
Regulation Of Immune Response
Toll-like Receptor 4 Signaling Pathway
Defense Response
Regulation Of Cytokine Production
Positive Regulation Of Immune Response
Regulation Of Immune System Process
Positive Regulation Of Immune System Process
Positive Regulation Of Interleukin-8 Production
Positive Regulation Of Cytokine Production
Regulation Of Interferon-beta Production
Response To Other Organism
I-kappaB Kinase/NF-kappaB Signaling
Regulation Of Signaling
Regulation Of Signal Transduction
Toll-like Receptor TLR6:TLR2 Signaling Pathway
Toll-like Receptor TLR1:TLR2 Signaling Pathway
Response To Biotic Stimulus
Toll-like Receptor 2 Signaling Pathway
Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Regulation Of Type I Interferon Production
Regulation Of Toll-like Receptor Signaling Pathway
Response To Stress
Positive Regulation Of Interferon-beta Production
Regulation Of Intracellular Signal Transduction
Response To External Stimulus
Inflammatory Response
Response To Organic Substance
Positive Regulation Of Signal Transduction
Positive Regulation Of Cytokine Biosynthetic Process
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of NF-kappaB Transcription Factor Activity
Positive Regulation Of Chemokine Production
Positive Regulation Of Type I Interferon Production
Positive Regulation Of Intracellular Signal Transduction
Positive Regulation Of Interferon-alpha Production
Regulation Of Protein Metabolic Process
Signal Transduction
Response To Stimulus
Regulation Of Chemokine Production
Enzyme Linked Receptor Protein Signaling Pathway
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Cellular Response To Organic Substance
Mammary Gland Development
Positive Regulation Of Cytokine Production
Response To Cytokine
Response To Organic Substance
JAK-STAT Cascade
Intracellular Signal Transduction
Regulation Of Cytokine Production
Cellular Response To Growth Factor Stimulus
Cellular Response To Cytokine Stimulus
Response To Growth Factor
Negative Regulation Of Cell Death
Immune System Process
JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway
Cell Surface Receptor Signaling Pathway
Growth Hormone Receptor Signaling Pathway
Immune System Development
Cellular Response To Growth Hormone Stimulus
Mammary Gland Epithelium Development
Regulation Of Nitrogen Compound Metabolic Process
Regulation Of Innate Immune Response
Positive Regulation Of Intracellular Signal Transduction
Positive Regulation Of Signal Transduction
Phosphorylation
Gland Development
Response To Lipid
Defense Response
Signal Transduction
Response To Growth Hormone
Negative Regulation Of Apoptotic Process
Negative Regulation Of Programmed Cell Death
Regulation Of Cell Proliferation
Signaling
Positive Regulation Of Macromolecule Biosynthetic Process
Leukocyte Differentiation
Cell Communication
Regulation Of Cell Death
Hemopoiesis
Positive Regulation Of Cellular Biosynthetic Process
Epithelium Development
Positive Regulation Of Innate Immune Response
Tissue Development
Cell Differentiation
Intracellular Receptor Signaling Pathway
Positive Regulation Of Cellular Metabolic Process
Inflammatory Response
Cytokine-mediated Signaling Pathway
Cellular Response To Stimulus
Tagcloud
?
binet
biology
birc3
briefer
chinese
cll
concurrent
confounded
consecutive
descent
diverse
etiology
european
fludarabine
frequencies
germline
give
ighv
insights
lymphocytic
mutated
mutations
notch1
persons
predominately
sf3b1
stratification
tp53
un
Tagcloud (Difference)
?
binet
biology
birc3
briefer
chinese
cll
concurrent
confounded
consecutive
descent
diverse
etiology
european
fludarabine
frequencies
germline
give
ighv
insights
lymphocytic
mutated
mutations
notch1
persons
predominately
sf3b1
stratification
tp53
un
Tagcloud (Intersection)
?