MYD88 and TLR8

Number of citations of the paper that reports this interaction (PMID 16482509)
13

Data Source:
HPRD (two hybrid)

		MYD88	TLR8
Gene Name		myeloid differentiation primary response 88	toll-like receptor 8
Image
Gene Ontology Annotations	Cellular Component	Cytosol Plasma Membrane Endosome Membrane	Golgi Membrane Endoplasmic Reticulum Membrane Endosome Membrane Integral Component Of Membrane Endolysosome Membrane
	Molecular Function	Death Receptor Binding Protein Binding Identical Protein Binding TIR Domain Binding	DNA Binding RNA Binding Double-stranded RNA Binding Single-stranded RNA Binding Receptor Activity Drug Binding
	Biological Process	Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Inflammatory Response Signal Transduction Cell Surface Receptor Signaling Pathway Positive Regulation Of Type I Interferon Production Positive Regulation Of Interleukin-17 Production Positive Regulation Of Interleukin-23 Production Positive Regulation Of Interleukin-6 Production Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Negative Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Neurotrophin TRK Receptor Signaling Pathway Regulation Of Inflammatory Response Defense Response To Gram-positive Bacterium Response To Interleukin-1 3'-UTR-mediated MRNA Stabilization Cellular Response To Mechanical Stimulus	Microglial Cell Activation Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Inflammatory Response I-kappaB Kinase/NF-kappaB Signaling Response To Virus Immunoglobulin Mediated Immune Response Toll-like Receptor 8 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Positive Regulation Of Interferon-gamma Biosynthetic Process Innate Immune Response Positive Regulation Of Innate Immune Response Positive Regulation Of Interferon-alpha Biosynthetic Process Positive Regulation Of Interferon-beta Biosynthetic Process Positive Regulation Of Interleukin-8 Biosynthetic Process Regulation Of Cytokine Secretion Defense Response To Virus Cellular Response To Mechanical Stimulus
Pathways		p75NTR recruits signalling complexes Toll Like Receptor 7/8 (TLR7/8) Cascade RIP-mediated NFkB activation via ZBP1 Toll Like Receptor TLR6:TLR2 Cascade DEx/H-box helicases activate type I IFN and inflammatory cytokines production Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade ZBP1(DAI) mediated induction of type I IFNs p75NTR signals via NF-kB MyD88 dependent cascade initiated on endosome MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Toll Like Receptor 9 (TLR9) Cascade Innate Immune System Signalling by NGF TRIF-mediated TLR3/TLR4 signaling Cytosolic sensors of pathogen-associated DNA Cytokine Signaling in Immune system p75 NTR receptor-mediated signalling MyD88-independent cascade Toll Like Receptor 2 (TLR2) Cascade RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Signaling by Interleukins Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade TRAF6 mediated IRF7 activation TRAF6 mediated NF-kB activation Interleukin-1 signaling TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling TAK1 activates NFkB by phosphorylation and activation of IKKs complex	Trafficking and processing of endosomal TLR Toll-Like Receptors Cascades Toll Like Receptor 7/8 (TLR7/8) Cascade MyD88 dependent cascade initiated on endosome TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling Toll Like Receptor 9 (TLR9) Cascade Innate Immune System
Drugs
Diseases
GWAS			Celiac disease ( 20190752)
Protein-Protein Interactions		39 interactors: BTK CD93 CISH FADD FLII IL1R1 IL1RAP IL1RL1 IRAK1 IRAK2 IRAK3 IRAK4 IRF4 IRF5 IRF7 MAL MBIP MDM2 PELI2 PFKL POLR1C PRDX1 RAC1 SARM1 SIAH1 SIAH2 SMAD3 SPOP STAP2 TIRAP TLR10 TLR2 TLR3 TLR4 TLR5 TLR7 TLR8 TXN USP7	3 interactors: BTK MYD88 UBC
Entrez ID		4615	51311
HPRD ID		03703	02296
Ensembl ID		ENSG00000172936	ENSG00000101916
Uniprot IDs		J3KPU4 J3KQ87 J3KQJ6 Q99836	Q9NR97
PDB IDs		2JS7 2Z5V 3MOP 4DOM 4EO7	3W3G 3W3J 3W3K 3W3L 3W3M 3W3N
Enriched GO Terms of Interacting Partners?		Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Positive Regulation Of Innate Immune Response Innate Immune Response Immune Response MyD88-dependent Toll-like Receptor Signaling Pathway Regulation Of Innate Immune Response Immune Response-regulating Signaling Pathway Immune System Process Regulation Of Immune Response Toll-like Receptor 4 Signaling Pathway Defense Response Regulation Of Cytokine Production Positive Regulation Of Immune Response Regulation Of Immune System Process Positive Regulation Of Immune System Process Positive Regulation Of Interleukin-8 Production Positive Regulation Of Cytokine Production Regulation Of Interferon-beta Production Response To Other Organism I-kappaB Kinase/NF-kappaB Signaling Regulation Of Signaling Regulation Of Signal Transduction Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Response To Biotic Stimulus Toll-like Receptor 2 Signaling Pathway Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Type I Interferon Production Regulation Of Toll-like Receptor Signaling Pathway Response To Stress Positive Regulation Of Interferon-beta Production Regulation Of Intracellular Signal Transduction Response To External Stimulus Inflammatory Response Response To Organic Substance Positive Regulation Of Signal Transduction Positive Regulation Of Cytokine Biosynthetic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Chemokine Production Positive Regulation Of Type I Interferon Production Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Interferon-alpha Production Regulation Of Protein Metabolic Process Signal Transduction Response To Stimulus Regulation Of Chemokine Production	Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor 4 Signaling Pathway Response To Molecule Of Fungal Origin Toll-like Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Positive Regulation Of Innate Immune Response Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Innate Immune Response Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Immune Response-regulating Signaling Pathway Response To Fungus Regulation Of Cytokine Production Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway I-kappaB Kinase/NF-kappaB Signaling Toll-like Receptor 9 Signaling Pathway Positive Regulation Of Immune Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Type I Interferon Production JNK Cascade Innate Immune Response Regulation Of Immune Response Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Immune System Process Regulation Of Type I Interferon Production Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Antigen Receptor-mediated Signaling Pathway Regulation Of B Cell Cytokine Production Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Immune Response Regulation Of Immune System Process Defense Response Cellular Response To Molecule Of Fungal Origin Neurotrophin TRK Receptor Signaling Pathway Regulation Of Apoptotic Process Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway Cellular Response To Stress MAPK Cascade Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Cell Death Leukocyte Mediated Immunity Fc Receptor Signaling Pathway
Tagcloud ?		binet biology birc3 briefer chinese cll concurrent confounded consecutive descent diverse etiology european fludarabine frequencies germline give ighv insights lymphocytic mutated mutations notch1 persons predominately sf3b1 stratification tp53 un	3m002 adaptive blotting cancerous cl075 clarify colon crc downstream il indicator innate mucosa myd88 possibility recurrence reduce serve signify stain tlr1 tlr2 tlr4 tlrs toll upregulation varied volunteers
Tagcloud (Difference) ?		binet biology birc3 briefer chinese cll concurrent confounded consecutive descent diverse etiology european fludarabine frequencies germline give ighv insights lymphocytic mutated mutations notch1 persons predominately sf3b1 stratification tp53 un	3m002 adaptive blotting cancerous cl075 clarify colon crc downstream il indicator innate mucosa possibility recurrence reduce serve signify stain tlr1 tlr2 tlr4 tlrs toll upregulation varied volunteers
Tagcloud (Intersection) ?		myd88