NPHS2 and CD2AP

Number of citations of the paper that reports this interaction (PMID 11733557)
86

Data Source:
BioGRID (affinity chromatography technology, pull down, affinity chromatography technology)
HPRD (in vivo, in vitro)

		NPHS2	CD2AP
Gene Name		nephrosis 2, idiopathic, steroid-resistant (podocin)	CD2-associated protein
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction Intrinsic Component Of The Cytoplasmic Side Of The Plasma Membrane Slit Diaphragm Protein Complex Membrane Raft Extracellular Vesicular Exosome	Ruffle Nucleolus Cytoplasm Plasma Membrane Cell-cell Junction Actin Cytoskeleton Filamentous Actin Extracellular Vesicular Exosome
	Molecular Function	Protein Binding	Structural Constituent Of Cytoskeleton Protein Binding SH3 Domain Binding
	Biological Process	Excretion Actin Cytoskeleton Reorganization Metanephric Glomerular Visceral Epithelial Cell Development	Protein Complex Assembly Substrate-dependent Cell Migration, Cell Extension Mitotic Nuclear Division Signal Transduction Negative Regulation Of Transforming Growth Factor Beta1 Production Cell Division Positive Regulation Of Protein Localization To Nucleus Regulation Of Actin Cytoskeleton Reorganization
Pathways		Nephrin interactions	Nephrin interactions
Drugs
Diseases
GWAS			Alzheimer's disease (late onset) ( 21460841)
Protein-Protein Interactions		4 interactors: CD2AP KIRREL KIRREL3 NPHS1	30 interactors: BCAR1 CAPZA1 CBL CD2 CTTN FYN GRB2 GZMB HBP1 HCK HOXC11 KHDRBS1 MVB12A NPHS1 NPHS2 NR2C2 NR4A1 PDCD6IP PIK3R1 PKD2 PSTPIP1 PTGES3 RAB4A SH3GL2 SOS1 SOS2 SRC UBC WTIP YES1
Entrez ID		7827	23607
HPRD ID		05303	05026
Ensembl ID		ENSG00000116218	ENSG00000198087
Uniprot IDs		Q9NP85	Q9Y5K6
PDB IDs			2FEI 2J6F 2J6K 2J6O 2J7I 3AA6 3LK4 3U23
Enriched GO Terms of Interacting Partners?		Regulation Of Actin Cytoskeleton Organization Regulation Of Actin Filament-based Process Excretion Regulation Of Cytoskeleton Organization Glomerulus Development Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Protein Polymerization Nephron Development Regulation Of Organelle Organization Positive Regulation Of Protein Complex Assembly Principal Sensory Nucleus Of Trigeminal Nerve Development Regulation Of Actin Filament Polymerization Positive Regulation Of Cytoskeleton Organization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Inter-male Aggressive Behavior Negative Regulation Of Transforming Growth Factor Beta1 Production Negative Regulation Of Transforming Growth Factor Beta Production Kidney Development Positive Regulation Of Cellular Component Biogenesis Regulation Of Cellular Component Size Renal System Development Regulation Of Protein Complex Assembly Urogenital System Development Glomerular Visceral Epithelial Cell Development Positive Regulation Of Organelle Organization Substrate-dependent Cell Migration, Cell Extension Aggressive Behavior Regulation Of Cellular Component Organization Glomerular Basement Membrane Development Glomerular Visceral Epithelial Cell Differentiation Glomerulus Morphogenesis Myoblast Fusion Regulation Of Excretion Syncytium Formation Substrate-dependent Cell Migration Regulation Of Actin Cytoskeleton Reorganization Cell Differentiation Involved In Kidney Development Cell Migration Cell Motility Neural Nucleus Development Myotube Differentiation Cell Projection Organization Cell Adhesion JNK Cascade Locomotion Positive Regulation Of Protein Localization To Nucleus Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade	Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Growth Factor Stimulus Neurotrophin TRK Receptor Signaling Pathway Response To Growth Factor Neurotrophin Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Immune Response-regulating Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Fc Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Immune System Process Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Signaling Regulation Of Cellular Component Organization Cell Communication Signal Transduction Leukocyte Migration Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Movement Of Cell Or Subcellular Component Regulation Of ERBB Signaling Pathway Locomotion Cellular Response To Hormone Stimulus Cellular Response To Organic Substance Blood Coagulation Hemostasis Innate Immune Response Cell Surface Receptor Signaling Pathway Cell Migration Cellular Response To Peptide Hormone Stimulus Regulation Of Immune Response Cellular Response To Peptide Cell Motility Response To Organic Substance Immune Response Regulation Of Immune System Process Regulation Of Body Fluid Levels Positive Regulation Of Organelle Organization Regulation Of Cellular Process Cellular Response To Stimulus Wound Healing Chemotaxis T Cell Costimulation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Response To Stimulus
Tagcloud ?		11t 13c 1678a 181g 279t 35a 38g 48t 718c 86t biotechnology boundaries d93d endonuclease glomerulosclerosis han ivs1 ivs16 ivs18 ivs19 ivs2 ivs25 ivs6 l240f myo1e nephrotic segmental srns t560a	abca7 bin1 cass4 cd33 celf1 chapter discoveries drb1 drb5 epha1 fermt2 inpp5d mef2c ms4a4 ms4a6 nme8 picalm pld3 psen1 psen2 ptk2b rin3 slc24a4 sorl1 touch trem2 trip4 unsuspected zcwpw1
Tagcloud (Difference) ?		11t 13c 1678a 181g 279t 35a 38g 48t 718c 86t biotechnology boundaries d93d endonuclease glomerulosclerosis han ivs1 ivs16 ivs18 ivs19 ivs2 ivs25 ivs6 l240f myo1e nephrotic segmental srns t560a	abca7 bin1 cass4 cd33 celf1 chapter discoveries drb1 drb5 epha1 fermt2 inpp5d mef2c ms4a4 ms4a6 nme8 picalm pld3 psen1 psen2 ptk2b rin3 slc24a4 sorl1 touch trem2 trip4 unsuspected zcwpw1
Tagcloud (Intersection) ?