NPHS2 and KIRREL3

Number of citations of the paper that reports this interaction (PMID 12424224)
42

Data Source:
HPRD (in vivo)

		NPHS2	KIRREL3
Gene Name		nephrosis 2, idiopathic, steroid-resistant (podocin)	kin of IRRE like 3 (Drosophila)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction Intrinsic Component Of The Cytoplasmic Side Of The Plasma Membrane Slit Diaphragm Protein Complex Membrane Raft Extracellular Vesicular Exosome	Extracellular Region Plasma Membrane Integral Component Of Membrane Axon Dendritic Shaft
	Molecular Function	Protein Binding	Protein Binding
	Biological Process	Excretion Actin Cytoskeleton Reorganization Metanephric Glomerular Visceral Epithelial Cell Development	Neuron Migration Inter-male Aggressive Behavior Principal Sensory Nucleus Of Trigeminal Nerve Development Hemopoiesis Neuron Projection Morphogenesis Glomerulus Morphogenesis
Pathways		Nephrin interactions	Nephrin interactions
Drugs
Diseases
GWAS			Attention deficit hyperactivity disorder and conduct disorder ( 18951430) Breast size ( 22747683) Menarche (age at onset) ( 23667675) Protein quantitative trait loci ( 18464913) Response to antipsychotic treatment ( 20195266)
Protein-Protein Interactions		4 interactors: CD2AP KIRREL KIRREL3 NPHS1	1 interactors: NPHS2
Entrez ID		7827	84623
HPRD ID		05303	09679
Ensembl ID		ENSG00000116218	ENSG00000149571
Uniprot IDs		Q9NP85	E9PRX9 Q8IZU9
PDB IDs			2CRY
Enriched GO Terms of Interacting Partners?		Regulation Of Actin Cytoskeleton Organization Regulation Of Actin Filament-based Process Excretion Regulation Of Cytoskeleton Organization Glomerulus Development Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Protein Polymerization Nephron Development Regulation Of Organelle Organization Positive Regulation Of Protein Complex Assembly Principal Sensory Nucleus Of Trigeminal Nerve Development Regulation Of Actin Filament Polymerization Positive Regulation Of Cytoskeleton Organization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Inter-male Aggressive Behavior Negative Regulation Of Transforming Growth Factor Beta1 Production Negative Regulation Of Transforming Growth Factor Beta Production Kidney Development Positive Regulation Of Cellular Component Biogenesis Regulation Of Cellular Component Size Renal System Development Regulation Of Protein Complex Assembly Urogenital System Development Glomerular Visceral Epithelial Cell Development Positive Regulation Of Organelle Organization Substrate-dependent Cell Migration, Cell Extension Aggressive Behavior Regulation Of Cellular Component Organization Glomerular Basement Membrane Development Glomerular Visceral Epithelial Cell Differentiation Glomerulus Morphogenesis Myoblast Fusion Regulation Of Excretion Syncytium Formation Substrate-dependent Cell Migration Regulation Of Actin Cytoskeleton Reorganization Cell Differentiation Involved In Kidney Development Cell Migration Cell Motility Neural Nucleus Development Myotube Differentiation Cell Projection Organization Cell Adhesion JNK Cascade Locomotion Positive Regulation Of Protein Localization To Nucleus Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade	Metanephric Glomerular Visceral Epithelial Cell Development Glomerular Visceral Epithelial Cell Development Cell Differentiation Involved In Metanephros Development Glomerular Visceral Epithelial Cell Differentiation Metanephric Glomerulus Development Metanephric Epithelium Development Metanephric Nephron Development Cell Differentiation Involved In Kidney Development Excretion Glomerulus Development Actin Cytoskeleton Reorganization Metanephros Development Nephron Development Kidney Epithelium Development Epithelial Cell Development Kidney Development Renal System Development Urogenital System Development Epithelial Cell Differentiation Actin Cytoskeleton Organization Actin Filament-based Process
Tagcloud ?		11t 13c 1678a 181g 279t 35a 38g 48t 718c 86t biotechnology boundaries d93d endonuclease glomerulosclerosis han ivs1 ivs16 ivs18 ivs19 ivs2 ivs25 ivs6 l240f myo1e nephrotic segmental srns t560a	cajal cdh cdh2 factored feline gist gists harbor hardy hif1a homeobox iccs igf1r igf2 insr kin lhx lhx2 lim molecularly neurofilament pdgfra sdh subpopulations succinate underscore zuckerman
Tagcloud (Difference) ?		11t 13c 1678a 181g 279t 35a 38g 48t 718c 86t biotechnology boundaries d93d endonuclease glomerulosclerosis han ivs1 ivs16 ivs18 ivs19 ivs2 ivs25 ivs6 l240f myo1e nephrotic segmental srns t560a	cajal cdh cdh2 factored feline gist gists harbor hardy hif1a homeobox iccs igf1r igf2 insr kin lhx lhx2 lim molecularly neurofilament pdgfra sdh subpopulations succinate underscore zuckerman
Tagcloud (Intersection) ?