NPHS2 and KIRREL

Number of citations of the paper that reports this interaction (PMID 12424224)
42

Data Source:
HPRD (in vivo, in vitro)

		NPHS2	KIRREL
Gene Name		nephrosis 2, idiopathic, steroid-resistant (podocin)	kin of IRRE like (Drosophila)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction Intrinsic Component Of The Cytoplasmic Side Of The Plasma Membrane Slit Diaphragm Protein Complex Membrane Raft Extracellular Vesicular Exosome	Plasma Membrane Cell-cell Junction Integral Component Of Membrane Cell Projection Membrane Dendritic Shaft Membrane Raft Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Protein Binding	Protein Binding Myosin Binding
	Biological Process	Excretion Actin Cytoskeleton Reorganization Metanephric Glomerular Visceral Epithelial Cell Development	Negative Regulation Of Protein Phosphorylation Excretion Single Organismal Cell-cell Adhesion Positive Regulation Of Actin Filament Polymerization
Pathways		Nephrin interactions
Drugs
Diseases
GWAS			Obesity-related traits ( 23251661)
Protein-Protein Interactions		4 interactors: CD2AP KIRREL KIRREL3 NPHS1	3 interactors: NPHS1 NPHS2 TJP1
Entrez ID		7827	55243
HPRD ID		05303	06306
Ensembl ID		ENSG00000116218	ENSG00000183853
Uniprot IDs		Q9NP85	Q96J84
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Actin Cytoskeleton Organization Regulation Of Actin Filament-based Process Excretion Regulation Of Cytoskeleton Organization Glomerulus Development Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Protein Polymerization Nephron Development Regulation Of Organelle Organization Positive Regulation Of Protein Complex Assembly Principal Sensory Nucleus Of Trigeminal Nerve Development Regulation Of Actin Filament Polymerization Positive Regulation Of Cytoskeleton Organization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Inter-male Aggressive Behavior Negative Regulation Of Transforming Growth Factor Beta1 Production Negative Regulation Of Transforming Growth Factor Beta Production Kidney Development Positive Regulation Of Cellular Component Biogenesis Regulation Of Cellular Component Size Renal System Development Regulation Of Protein Complex Assembly Urogenital System Development Glomerular Visceral Epithelial Cell Development Positive Regulation Of Organelle Organization Substrate-dependent Cell Migration, Cell Extension Aggressive Behavior Regulation Of Cellular Component Organization Glomerular Basement Membrane Development Glomerular Visceral Epithelial Cell Differentiation Glomerulus Morphogenesis Myoblast Fusion Regulation Of Excretion Syncytium Formation Substrate-dependent Cell Migration Regulation Of Actin Cytoskeleton Reorganization Cell Differentiation Involved In Kidney Development Cell Migration Cell Motility Neural Nucleus Development Myotube Differentiation Cell Projection Organization Cell Adhesion JNK Cascade Locomotion Positive Regulation Of Protein Localization To Nucleus Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade	Glomerular Visceral Epithelial Cell Development Epithelial Cell Development Glomerular Visceral Epithelial Cell Differentiation Cell Differentiation Involved In Kidney Development Excretion Epithelial Cell Differentiation Glomerulus Development Epithelium Development Nephron Development Cell-cell Signaling Involved In Cell-cell Junction Organization Kidney Epithelium Development Metanephric Glomerular Visceral Epithelial Cell Development Tissue Development Response To Magnetism Cell Development Kidney Development Renal System Development Urogenital System Development Establishment Of Endothelial Intestinal Barrier Cell Differentiation Involved In Metanephros Development Negative Regulation Of Vascular Permeability Glomerular Basement Membrane Development Metanephric Glomerulus Development Myoblast Fusion Regulation Of Excretion Cell Differentiation Establishment Of Endothelial Barrier Hippo Signaling Metanephric Epithelium Development Regulation Of Vascular Permeability Syncytium Formation Blastocyst Formation Metanephric Nephron Development Anatomical Structure Formation Involved In Morphogenesis Endothelial Cell Development Myotube Differentiation Cellular Response To Glucose Stimulus Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Multicellular Organismal Development Actin Cytoskeleton Reorganization Anatomical Structure Development Execution Phase Of Apoptosis Cellular Glucose Homeostasis Cellular Response To Carbohydrate Stimulus Endothelial Cell Differentiation JNK Cascade Endothelium Development Developmental Process Blastocyst Development Metanephros Development
Tagcloud ?		11t 13c 1678a 181g 279t 35a 38g 48t 718c 86t biotechnology boundaries d93d endonuclease glomerulosclerosis han ivs1 ivs16 ivs18 ivs19 ivs2 ivs25 ivs6 l240f myo1e nephrotic segmental srns t560a	cajal cdh cdh2 factored feline gist gists harbor hardy hif1a homeobox iccs igf1r igf2 insr kin lhx lhx2 lim molecularly neurofilament pdgfra sdh subpopulations succinate underscore zuckerman
Tagcloud (Difference) ?		11t 13c 1678a 181g 279t 35a 38g 48t 718c 86t biotechnology boundaries d93d endonuclease glomerulosclerosis han ivs1 ivs16 ivs18 ivs19 ivs2 ivs25 ivs6 l240f myo1e nephrotic segmental srns t560a	cajal cdh cdh2 factored feline gist gists harbor hardy hif1a homeobox iccs igf1r igf2 insr kin lhx lhx2 lim molecularly neurofilament pdgfra sdh subpopulations succinate underscore zuckerman
Tagcloud (Intersection) ?