CACNA1B and RIMS1

Number of citations of the paper that reports this interaction (PubMedID 11438518)
0

Data Source:
HPRD (in vitro)

		CACNA1B	RIMS1
Description		calcium voltage-gated channel subunit alpha1 B	regulating synaptic membrane exocytosis 1
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GO Annotations	Cellular Component	Plasma Membrane Voltage-gated Calcium Channel Complex Membrane Monoatomic Ion Channel Complex Neuronal Cell Body Synapse	Cytosol Plasma Membrane Membrane Presynaptic Membrane Cell Projection Synapse Presynaptic Active Zone Presynaptic Active Zone Cytoplasmic Component
	Molecular Function	Nucleotide Binding Amyloid-beta Binding Monoatomic Ion Channel Activity Voltage-gated Calcium Channel Activity Calcium Channel Activity Calcium Ion Binding Protein Binding ATP Binding High Voltage-gated Calcium Channel Activity Metal Ion Binding	RNA Binding Protein Binding Zinc Ion Binding GTPase Regulator Activity Small GTPase Binding Metal Ion Binding Structural Constituent Of Presynaptic Active Zone
	Biological Process	Monoatomic Ion Transport Calcium Ion Transport Chemical Synaptic Transmission Monoatomic Ion Transmembrane Transport Modulation Of Chemical Synaptic Transmission Transmembrane Transport Calcium Ion Transmembrane Transport Calcium Ion Import Across Plasma Membrane Positive Regulation Of Calcium Ion-dependent Exocytosis Of Neurotransmitter Response To Amyloid-beta	Neurotransmitter Transport Intracellular Protein Transport Exocytosis Visual Perception Positive Regulation Of Gene Expression Synaptic Vesicle Exocytosis Synaptic Vesicle Docking Synaptic Vesicle Priming Calcium-ion Regulated Exocytosis Cell Differentiation Regulated Exocytosis Secretion Regulation Of Neurotransmitter Secretion Maintenance Of Presynaptic Active Zone Structure Acrosomal Vesicle Exocytosis Membrane Fusion Protein-containing Complex Assembly Positive Regulation Of Inhibitory Postsynaptic Potential Positive Regulation Of Dendrite Extension Regulation Of Synaptic Vesicle Exocytosis Positive Regulation Of Excitatory Postsynaptic Potential
Pathways		Presynaptic depolarization and calcium channel opening	Serotonin Neurotransmitter Release Cycle Norepinephrine Neurotransmitter Release Cycle Glutamate Neurotransmitter Release Cycle Dopamine Neurotransmitter Release Cycle Acetylcholine Neurotransmitter Release Cycle GABA synthesis, release, reuptake and degradation
Drugs		Eptifibatide Ergocalciferol Enflurane Amlodipine Amlodipine Spironolactone Nicardipine Verapamil Verapamil Gabapentin Levetiracetam Seletracetam Contulakin-G Ziconotide Agmatine Benidipine Cilnidipine Efonidipine Butamben Bioallethrin
Diseases			Cone-rod dystrophy and cone dystrophy, including: Cone-rod dystrophy (CORD); Cone dystrophy (COD); Retinal cone dystrophy (RCD)
GWAS		Asparaginase hypersensitivity in acute lymphoblastic leukemia ( 25987655) Bipolar disorder ( 31043756) Body mass index ( 28552196) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Parkinson's disease ( 32201043) Weight ( 28552196)	Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced) ( 24236485) Adverse response to chemotherapy (amenorrhea) in breast cancer ( 31371054) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 33263727 31043756) Chronotype ( 30696823) Cognitive performance ( 20125193) LDL levels x SSRI levels (escitalopram or citalopram) interaction in schizophrenia or bipolar disorder ( 33824429) Lung cancer ( 28604730) Lung cancer in never smokers ( 28604730) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Refractive error ( 32231278) Response to mTOR inhibitor (rapamycin) ( 24009623) Rosacea symptom severity ( 29771307) Schizophrenia ( 30285260 29483656 25056061) Squamous cell lung carcinoma ( 28604730) Total cholesterol levels x SSRI levels (escitalopram or citalopram) interaction in schizophrenia or bipolar disorder ( 33824429) Triglyceride levels ( 32203549)
Interacting Genes		10 interacting genes: APBA1 CACNB3 CAMK2A GNAO1 GNB1 PDLIM5 PPM1A RGS12 RIMS1 RXRB	16 interacting genes: CACNA1B CACNA1C CAMK2A ERC1 ERC2 RAB10 RAB26 RAB27A RAB37 RAB3A RNF10 SNAP25 STX1A SYT1 UNC13B YWHAH
Entrez ID		774	22999
HPRD ID		03005	09435
Ensembl ID		ENSG00000148408	ENSG00000079841
Uniprot IDs		Q00975	B7Z7W2 B7Z9Z3 Q3ZCW0 Q86UR5
PDB IDs		2LCM 7MIX 7MIY 7VFS 7VFU 7VFV 7VFW	2CSS
Enriched GO Terms of Interacting Partners?		Synapse Modulation Of Chemical Synaptic Transmission G Protein-coupled Dopamine Receptor Signaling Pathway GTPase Regulator Activity Heterotrimeric G-protein Complex Cytosol Vesicle Docking Involved In Exocytosis Regulation Of Cell Communication Regulation Of Signaling Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel Regulation Of Transport Positive Regulation Of High Voltage-gated Calcium Channel Activity Peptidyl-threonine Autophosphorylation G Protein-coupled Receptor Signaling Pathway Regulation Of Neurotransmitter Secretion Mu-type Opioid Receptor Binding Membrane Docking GTPase Activity Vesicle Docking Organelle Localization By Membrane Tethering Regulation Of Endocannabinoid Signaling Pathway G Protein-coupled Serotonin Receptor Binding Cytoplasm Dendrite Corticotropin-releasing Hormone Receptor 1 Binding Adenylate Cyclase Regulator Activity N-terminal Protein Myristoylation Dendritic Spine Gamma-aminobutyric Acid Secretion Intracellular Protein Transport Positive Regulation Of Voltage-gated Calcium Channel Activity Calcium- And Calmodulin-dependent Protein Kinase Complex Regulation Of G Protein-coupled Receptor Signaling Pathway Presynaptic Membrane Calmodulin-dependent Protein Phosphatase Activity Ventricular Cardiac Muscle Cell Differentiation Positive Regulation Of Vitamin D Receptor Signaling Pathway Acrosomal Vesicle Exocytosis Positive Regulation Of Inhibitory Postsynaptic Potential Regulation Of Secretion By Cell Glutamate Receptor Binding Cell Projection Retinoic Acid-responsive Element Binding Structural Constituent Of Presynaptic Active Zone Modulation Of Inhibitory Postsynaptic Potential	Regulated Exocytosis Exocytosis Regulation Of Secretion By Cell Regulation Of Secretion Regulation Of Transport Calcium-ion Regulated Exocytosis Synapse Regulation Of Exocytosis Positive Regulation Of Regulated Secretory Pathway Secretion By Cell Presynaptic Membrane Positive Regulation Of Exocytosis Secretion Regulation Of Neurotransmitter Secretion Regulation Of Calcium Ion-dependent Exocytosis Of Neurotransmitter Regulation Of Vesicle-mediated Transport Synaptic Vesicle Exocytosis Vesicle-mediated Transport Maintenance Of Presynaptic Active Zone Structure Regulation Of Calcium Ion-dependent Exocytosis Presynaptic Active Zone Presynaptic Active Zone Organization Regulation Of Regulated Secretory Pathway Synaptic Vesicle Membrane Synaptic Vesicle Docking Positive Regulation Of Synaptic Transmission Positive Regulation Of Secretion By Cell Modulation Of Chemical Synaptic Transmission Vesicle Docking Myosin V Binding Positive Regulation Of Secretion Positive Regulation Of Calcium Ion-dependent Exocytosis Synaptic Vesicle Priming Syntaxin-1 Binding Positive Regulation Of Neurotransmitter Secretion Organelle Localization By Membrane Tethering Regulation Of Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Membrane Docking Vesicle-mediated Transport In Synapse Exocytic Vesicle Positive Regulation Of Calcium Ion-dependent Exocytosis Of Neurotransmitter Neurotransmitter Transport Clathrin-sculpted Acetylcholine Transport Vesicle Membrane Maintenance Of Synapse Structure Establishment Of Vesicle Localization Organelle Localization Protein Transport Clathrin-sculpted Glutamate Transport Vesicle Membrane Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex Regulation Of Vesicle Fusion
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