CACNA1B and RXRB

Number of citations of the paper that reports this interaction (PMID 20195357)
18

Data Source:
BioGRID (pull down)

		CACNA1B	RXRB
Gene Name		calcium channel, voltage-dependent, N type, alpha 1B subunit	retinoid X receptor, beta
Image
Gene Ontology Annotations	Cellular Component	Plasma Membrane Voltage-gated Calcium Channel Complex Dendrite Neuronal Cell Body	Nucleus Nucleoplasm
	Molecular Function	Voltage-gated Calcium Channel Activity Calcium Ion Binding Protein Binding ATP Binding Protein C-terminus Binding High Voltage-gated Calcium Channel Activity	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Sequence-specific DNA Binding Transcription Factor Activity Steroid Hormone Receptor Activity Transcription Coactivator Activity Ligand-activated Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity 9-cis Retinoic Acid Receptor Activity Protein Binding Zinc Ion Binding Protein Homodimerization Activity
	Biological Process	Transport Synaptic Transmission Neurotransmitter Secretion Locomotory Behavior Regulation Of Heart Contraction Regulation Of Blood Pressure Regulation Of Ion Transmembrane Transport Response To Pain Membrane Depolarization Regulation Of Calcium Ion Transport Calcium Ion Import Calcium Ion Transmembrane Transport Membrane Depolarization During Action Potential	In Utero Embryonic Development Maternal Placenta Development Transcription Initiation From RNA Polymerase II Promoter Gene Expression Steroid Hormone Mediated Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter Retinoic Acid Receptor Signaling Pathway Ventricular Cardiac Muscle Cell Differentiation Transmembrane Transport Cardiac Muscle Cell Proliferation Cellular Response To Retinoic Acid
Pathways		Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels Transmission across Chemical Synapses	Generic Transcription Pathway Signaling by Retinoic Acid Nuclear Receptor transcription pathway Orphan transporters
Drugs			Adapalene Bexarotene Acitretin Alitretinoin Tretinoin Tazarotene Etretinate 6-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-Tetrahydronaphthalen-2-Yl)Cyclopropyl]Pyridine-3-Carboxylic Acid N-(2,2,2-TRIFLUOROETHYL)-N-{4-[2,2,2-TRIFLUORO-1-HYDROXY-1-(TRIFLUOROMETHYL)ETHYL]PHENYL}BENZENESULFONAMIDE N-(TERT-BUTYL)-3,5-DIMETHYL-N\'-[(5-METHYL-2,3-DIHYDRO-1,4-BENZODIOXIN-6-YL)CARBONYL]BENZOHYDRAZIDE (2E,4E)-11-METHOXY-3,7,11-TRIMETHYLDODECA-2,4-DIENOIC ACID
Diseases
GWAS			Wegener's granulomatosis ( 23740775)
Protein-Protein Interactions		9 interactors: APBA1 CACNB3 GNAO1 GNB1 PDLIM5 PPM1A RGS12 RIMS1 RXRB	32 interactors: AKAP13 CACNA1B GRIP1 GTF2H1 MAP4 MED1 NCOA1 NCOA3 NR0B2 NR1H2 NR1H3 NR1I2 NR2C2 NR2E3 NR3C1 NR4A2 NRIP1 PPARD PPARG PTMS RARA RARB RARG SPOP SRA1 SRC TACC2 TAF11 THRA THRB VDR ZDHHC12
Entrez ID		774	6257
HPRD ID		03005	01578
Ensembl ID		ENSG00000148408	ENSG00000204231
Uniprot IDs		B1AQK4 B1AQK7 Q00975	E9PK95 P28702 Q5STP9
PDB IDs		2LCM	1H9U 1UHL
Enriched GO Terms of Interacting Partners?		Glutamate Secretion Synaptic Transmission Dopamine Receptor Signaling Pathway Signaling Cell Communication Acid Secretion Cell-cell Signaling Dicarboxylic Acid Transport Membrane Depolarization Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Cellular Response To Hormone Stimulus G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Gamma-aminobutyric Acid Secretion System Development Amino Acid Transport Transcription Initiation From RNA Polymerase II Promoter Negative Regulation Of SMAD Protein Complex Assembly Positive Regulation Of Inhibitory Postsynaptic Membrane Potential Cellular Response To Acid Chemical Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of Calcium Ion Transport Cardiac Muscle Cell Apoptotic Process Muscle Cell Apoptotic Process Response To Organonitrogen Compound Multicellular Organismal Development DNA-templated Transcription, Initiation Calcium Ion-dependent Exocytosis Of Neurotransmitter N-terminal Protein Myristoylation Locomotory Behavior Gamma-aminobutyric Acid Transport Protein Myristoylation Anatomical Structure Development Response To Organic Cyclic Compound Response To Hormone Regulation Of Membrane Potential Positive Regulation Of Metabolic Process Peptidyl-threonine Dephosphorylation Signal Transduction Cellular Response To Prostaglandin E Stimulus Regulation Of Inhibitory Postsynaptic Membrane Potential G-protein Coupled Acetylcholine Receptor Signaling Pathway Carboxylic Acid Transport Organic Acid Transport Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Developmental Process Negative Regulation Of NF-kappaB Import Into Nucleus Nervous System Development Cellular Response To Prostaglandin Stimulus	Intracellular Receptor Signaling Pathway Transcription Initiation From RNA Polymerase II Promoter Steroid Hormone Mediated Signaling Pathway Hormone-mediated Signaling Pathway Cellular Response To Steroid Hormone Stimulus DNA-templated Transcription, Initiation Cellular Response To Hormone Stimulus Response To Steroid Hormone Cellular Response To Organic Cyclic Compound Cellular Response To Lipid Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Response To Hormone Positive Regulation Of Cellular Biosynthetic Process Response To Lipid Response To Organic Cyclic Compound Positive Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Intracellular Steroid Hormone Receptor Signaling Pathway RNA Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Gene Expression Response To Organic Substance Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Gene Expression Regulation Of RNA Metabolic Process Negative Regulation Of Biosynthetic Process Biosynthetic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Apoptotic Process Regulation Of Cell Death
Tagcloud ?		annealed arguably asd autism bd bipolar candidates chip cnvs disparate fgfr1 glycogen gsk3beta gwass incorporated investigators lithium microarrays nrng pathophysiology pcdh9 phosphoinositide revolving salts searches seemingly shortcomings snap29 sz	2riibp aa acceptor bands cdnas coding cpg deduced designated exons extra finger heterodimers intron island isoforms midst mrxr northern phylogenic spleen spliced splicing superfamily transactivation transcribed twofold zinc
Tagcloud (Difference) ?		annealed arguably asd autism bd bipolar candidates chip cnvs disparate fgfr1 glycogen gsk3beta gwass incorporated investigators lithium microarrays nrng pathophysiology pcdh9 phosphoinositide revolving salts searches seemingly shortcomings snap29 sz	2riibp aa acceptor bands cdnas coding cpg deduced designated exons extra finger heterodimers intron island isoforms midst mrxr northern phylogenic spleen spliced splicing superfamily transactivation transcribed twofold zinc
Tagcloud (Intersection) ?