CACNA1B and PPM1A

Number of citations of the paper that reports this interaction (PubMedID 15728831)
53

Data Source:
HPRD (in vitro, in vivo)

		CACNA1B	PPM1A
Description		calcium voltage-gated channel subunit alpha1 B	protein phosphatase, Mg2+/Mn2+ dependent 1A
Image
GO Annotations	Cellular Component	Plasma Membrane Voltage-gated Calcium Channel Complex Membrane Monoatomic Ion Channel Complex Neuronal Cell Body Synapse	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Membrane
	Molecular Function	Nucleotide Binding Amyloid-beta Binding Monoatomic Ion Channel Activity Voltage-gated Calcium Channel Activity Calcium Channel Activity Calcium Ion Binding Protein Binding ATP Binding High Voltage-gated Calcium Channel Activity Metal Ion Binding	Magnesium Ion Binding Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Binding Hydrolase Activity Manganese Ion Binding Calmodulin-dependent Protein Phosphatase Activity Cation Binding Metal Ion Binding R-SMAD Binding
	Biological Process	Monoatomic Ion Transport Calcium Ion Transport Chemical Synaptic Transmission Monoatomic Ion Transmembrane Transport Modulation Of Chemical Synaptic Transmission Transmembrane Transport Calcium Ion Transmembrane Transport Calcium Ion Import Across Plasma Membrane Positive Regulation Of Calcium Ion-dependent Exocytosis Of Neurotransmitter Response To Amyloid-beta	Negative Regulation Of Transcription By RNA Polymerase II Protein Dephosphorylation N-terminal Protein Myristoylation Protein Export From Nucleus Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of BMP Signaling Pathway Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of DNA-templated Transcription Positive Regulation Of Protein Export From Nucleus Regulation Of Cell Cycle Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Non-canonical NF-kappaB Signal Transduction
Pathways		Presynaptic depolarization and calcium channel opening	Downregulation of SMAD2/3:SMAD4 transcriptional activity Energy dependent regulation of mTOR by LKB1-AMPK
Drugs		Eptifibatide Ergocalciferol Enflurane Amlodipine Amlodipine Spironolactone Nicardipine Verapamil Verapamil Gabapentin Levetiracetam Seletracetam Contulakin-G Ziconotide Agmatine Benidipine Cilnidipine Efonidipine Butamben Bioallethrin
Diseases
GWAS		Asparaginase hypersensitivity in acute lymphoblastic leukemia ( 25987655) Bipolar disorder ( 31043756) Body mass index ( 28552196) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Parkinson's disease ( 32201043) Weight ( 28552196)	Allergic rhinitis ( 22036096) Blond vs. brown/black hair color ( 30531825) Chronotype ( 30696823) Diastolic blood pressure ( 30224653) Hair color ( 29662168) Hip circumference adjusted for BMI ( 25673412) Menarche (age at onset) ( 27182965) Refractive error ( 32231278) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		10 interacting genes: APBA1 CACNB3 CAMK2A GNAO1 GNB1 PDLIM5 PPM1A RGS12 RIMS1 RXRB	38 interacting genes: AATK AKT1 ALK CACNA1A CACNA1B CACNA1C CDC42BPA CDC42BPB CTNNB1 DVL1 DVL2 DVL3 EEF2 EGFR ERBB2 ERBB3 ERBB4 FGFR2 GRM3 HSPB1 IGF1R KDR LMTK2 MID1 MSN NR4A1 PAK1 PAK2 PIK3R1 PLK3 PRKAA1 PRKCA PRKCD PTK7 ROR2 RPLP0 SMAD2 SMAD3
Entrez ID		774	5494
HPRD ID		03005	16199
Ensembl ID		ENSG00000148408	ENSG00000100614
Uniprot IDs		Q00975	B2R8E4 P35813
PDB IDs		2LCM 7MIX 7MIY 7VFS 7VFU 7VFV 7VFW	1A6Q 3FXJ 3FXK 3FXL 3FXM 3FXO 4RA2 4RAF 4RAG 6B67
Enriched GO Terms of Interacting Partners?		Synapse Modulation Of Chemical Synaptic Transmission G Protein-coupled Dopamine Receptor Signaling Pathway GTPase Regulator Activity Heterotrimeric G-protein Complex Cytosol Vesicle Docking Involved In Exocytosis Regulation Of Cell Communication Regulation Of Signaling Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel Regulation Of Transport Positive Regulation Of High Voltage-gated Calcium Channel Activity Peptidyl-threonine Autophosphorylation G Protein-coupled Receptor Signaling Pathway Regulation Of Neurotransmitter Secretion Mu-type Opioid Receptor Binding Membrane Docking GTPase Activity Vesicle Docking Organelle Localization By Membrane Tethering Regulation Of Endocannabinoid Signaling Pathway G Protein-coupled Serotonin Receptor Binding Cytoplasm Dendrite Corticotropin-releasing Hormone Receptor 1 Binding Adenylate Cyclase Regulator Activity N-terminal Protein Myristoylation Dendritic Spine Gamma-aminobutyric Acid Secretion Intracellular Protein Transport Positive Regulation Of Voltage-gated Calcium Channel Activity Calcium- And Calmodulin-dependent Protein Kinase Complex Regulation Of G Protein-coupled Receptor Signaling Pathway Presynaptic Membrane Calmodulin-dependent Protein Phosphatase Activity Ventricular Cardiac Muscle Cell Differentiation Positive Regulation Of Vitamin D Receptor Signaling Pathway Acrosomal Vesicle Exocytosis Positive Regulation Of Inhibitory Postsynaptic Potential Regulation Of Secretion By Cell Glutamate Receptor Binding Cell Projection Retinoic Acid-responsive Element Binding Structural Constituent Of Presynaptic Active Zone Modulation Of Inhibitory Postsynaptic Potential	Protein Kinase Activity Kinase Activity Protein Tyrosine Kinase Activity ATP Binding Enzyme-linked Receptor Protein Signaling Pathway Protein Phosphorylation Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Phosphorylation Positive Regulation Of Cell Communication Positive Regulation Of Signaling Cell Surface Receptor Signaling Pathway Response To Growth Factor Positive Regulation Of Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Activity Nucleotide Binding Cellular Response To Growth Factor Stimulus Regulation Of Cell Communication Regulation Of Signaling Regulation Of MAPK Cascade Transferase Activity Intracellular Signal Transduction Receptor Complex Negative Regulation Of Apoptotic Process Positive Regulation Of Epithelial Cell Proliferation Cell Migration Negative Regulation Of Programmed Cell Death Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Intracellular Signaling Cassette Positive Regulation Of MAPK Cascade Protein Serine Kinase Activity Protein Autophosphorylation Regulation Of Apoptotic Process Cell Motility Regulation Of Protein Localization Regulation Of Epithelial Cell Proliferation Regulation Of Programmed Cell Death Cell-cell Junction Protein Serine/threonine Kinase Activity Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Peptidyl-tyrosine Phosphorylation Plasma Membrane Positive Regulation Of Protein Localization Protein Kinase Binding Regulation Of Developmental Process Positive Regulation Of Cell Population Proliferation Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Cellular Component Organization
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