CACNA1B and CACNB3

Number of citations of the paper that reports this interaction (PubMedID 12161429)
0

Data Source:
HPRD (in vitro)

		CACNA1B	CACNB3
Description		calcium voltage-gated channel subunit alpha1 B	calcium voltage-gated channel auxiliary subunit beta 3
Image
GO Annotations	Cellular Component	Plasma Membrane Voltage-gated Calcium Channel Complex Membrane Monoatomic Ion Channel Complex Neuronal Cell Body Synapse	Cytoplasm Cytosol Voltage-gated Calcium Channel Complex Membrane Monoatomic Ion Channel Complex Synapse L-type Voltage-gated Calcium Channel Complex
	Molecular Function	Nucleotide Binding Amyloid-beta Binding Monoatomic Ion Channel Activity Voltage-gated Calcium Channel Activity Calcium Channel Activity Calcium Ion Binding Protein Binding ATP Binding High Voltage-gated Calcium Channel Activity Metal Ion Binding	Voltage-gated Calcium Channel Activity Calcium Channel Regulator Activity Calcium Channel Activity Protein Binding High Voltage-gated Calcium Channel Activity
	Biological Process	Monoatomic Ion Transport Calcium Ion Transport Chemical Synaptic Transmission Monoatomic Ion Transmembrane Transport Modulation Of Chemical Synaptic Transmission Transmembrane Transport Calcium Ion Transmembrane Transport Calcium Ion Import Across Plasma Membrane Positive Regulation Of Calcium Ion-dependent Exocytosis Of Neurotransmitter Response To Amyloid-beta	Monoatomic Ion Transport Calcium Ion Transport Chemical Synaptic Transmission Monoatomic Ion Transmembrane Transport T Cell Receptor Signaling Pathway Calcium Ion Transport Into Cytosol Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel Calcium Ion Transmembrane Transport Protein Localization To Plasma Membrane Regulation Of Membrane Repolarization During Action Potential Positive Regulation Of High Voltage-gated Calcium Channel Activity
Pathways		Presynaptic depolarization and calcium channel opening	Presynaptic depolarization and calcium channel opening Adrenaline,noradrenaline inhibits insulin secretion NCAM1 interactions Regulation of insulin secretion Regulation of insulin secretion Mechanical load activates signaling by PIEZO1 and integrins in osteocytes
Drugs		Eptifibatide Ergocalciferol Enflurane Amlodipine Amlodipine Spironolactone Nicardipine Verapamil Verapamil Gabapentin Levetiracetam Seletracetam Contulakin-G Ziconotide Agmatine Benidipine Cilnidipine Efonidipine Butamben Bioallethrin	Ergocalciferol Enflurane Ranolazine Phenytoin Topiramate Nimodipine Spironolactone Nicardipine Magnesium sulfate Verapamil Levomenthol Nitrendipine Miconazole Amiodarone Mibefradil Dronedarone Nilvadipine Drotaverine Trimebutine Benidipine Cilnidipine Efonidipine Efonidipine Lacidipine Manidipine Butamben Bioallethrin Bioallethrin Fish oil
Diseases
GWAS		Asparaginase hypersensitivity in acute lymphoblastic leukemia ( 25987655) Bipolar disorder ( 31043756) Body mass index ( 28552196) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Parkinson's disease ( 32201043) Weight ( 28552196)
Interacting Genes		10 interacting genes: APBA1 CACNB3 CAMK2A GNAO1 GNB1 PDLIM5 PPM1A RGS12 RIMS1 RXRB	11 interacting genes: CACNA1B CACNA1C CEP76 CIMIP1 CTBP2 FASLG GEM MEOX1 MTUS2 SKIC2 SYT1
Entrez ID		774	784
HPRD ID		03005	11879
Ensembl ID		ENSG00000148408	ENSG00000167535
Uniprot IDs		Q00975	P54284
PDB IDs		2LCM 7MIX 7MIY 7VFS 7VFU 7VFV 7VFW	7MIX 7MIY 7UHF 7UHG 8E59 8E5A 8E5B 8EPL 8FHS 8WE6 8WE7 8WE8 8WE9 8X90 8X91 8X93
Enriched GO Terms of Interacting Partners?		Synapse Modulation Of Chemical Synaptic Transmission G Protein-coupled Dopamine Receptor Signaling Pathway GTPase Regulator Activity Heterotrimeric G-protein Complex Cytosol Vesicle Docking Involved In Exocytosis Regulation Of Cell Communication Regulation Of Signaling Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel Regulation Of Transport Positive Regulation Of High Voltage-gated Calcium Channel Activity Peptidyl-threonine Autophosphorylation G Protein-coupled Receptor Signaling Pathway Regulation Of Neurotransmitter Secretion Mu-type Opioid Receptor Binding Membrane Docking GTPase Activity Vesicle Docking Organelle Localization By Membrane Tethering Regulation Of Endocannabinoid Signaling Pathway G Protein-coupled Serotonin Receptor Binding Cytoplasm Dendrite Corticotropin-releasing Hormone Receptor 1 Binding Adenylate Cyclase Regulator Activity N-terminal Protein Myristoylation Dendritic Spine Gamma-aminobutyric Acid Secretion Intracellular Protein Transport Positive Regulation Of Voltage-gated Calcium Channel Activity Calcium- And Calmodulin-dependent Protein Kinase Complex Regulation Of G Protein-coupled Receptor Signaling Pathway Presynaptic Membrane Calmodulin-dependent Protein Phosphatase Activity Ventricular Cardiac Muscle Cell Differentiation Positive Regulation Of Vitamin D Receptor Signaling Pathway Acrosomal Vesicle Exocytosis Positive Regulation Of Inhibitory Postsynaptic Potential Regulation Of Secretion By Cell Glutamate Receptor Binding Cell Projection Retinoic Acid-responsive Element Binding Structural Constituent Of Presynaptic Active Zone Modulation Of Inhibitory Postsynaptic Potential	Positive Regulation Of Calcium Ion-dependent Exocytosis Of Neurotransmitter Positive Regulation Of Synaptic Vesicle Exocytosis Regulation Of Calcium Ion-dependent Exocytosis Of Neurotransmitter Calcium Ion Transmembrane Import Into Cytosol High Voltage-gated Calcium Channel Activity Positive Regulation Of Calcium Ion-dependent Exocytosis Positive Regulation Of Neurotransmitter Secretion Calcium Ion Import Across Plasma Membrane Calcium Ion Import Into Cytosol Voltage-gated Calcium Channel Complex Voltage-gated Calcium Channel Activity Calcium Ion Import Calcium Ion Transmembrane Transport Calmodulin Binding Regulation Of Calcium Ion-dependent Exocytosis Metal Ion Transport Calcium Ion Transport Positive Regulation Of Regulated Secretory Pathway Regulation Of Synaptic Vesicle Exocytosis Fast, Calcium Ion-dependent Exocytosis Of Neurotransmitter Synchronous Neurotransmitter Secretion Cell Communication Monoatomic Cation Transport Retinal Cell Programmed Cell Death Positive Regulation Of Phosphatidylserine Exposure On Apoptotic Cell Surface Calcium Channel Activity Regulation Of Neurotransmitter Secretion Positive Regulation Of Exocytosis Inorganic Cation Import Across Plasma Membrane Membrane Depolarization During Atrial Cardiac Muscle Cell Action Potential Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel Voltage-gated Calcium Channel Activity Involved In AV Node Cell Action Potential Voltage-gated Calcium Channel Activity Involved In Cardiac Muscle Cell Action Potential Positive Regulation Of Chromatin Organization Y Chromosome Positive Regulation Of Heterochromatin Formation Cyclin A1-CDK2 Complex Cyclin-dependent Protein Kinase Activity Cyclin A2-CDK2 Complex Cyclin E1-CDK2 Complex Cyclin E2-CDK2 Complex Positive Regulation Of DNA-templated DNA Replication Initiation Sclerotome Development Ski Complex Nuclear-transcribed MRNA Catabolic Process, 3'-5' Exonucleolytic Nonsense-mediated Decay Clathrin-sculpted Acetylcholine Transport Vesicle Membrane Syntaxin-3 Binding Cytoplasmic Vesicle Lumen Monoatomic Ion Transport X Chromosome
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