USP39 and DNAAF5

Number of citations: 21 (PubMedID 36276075)
Data Source: BioGRID (pull down, pull down)

		USP39	DNAAF5
Name		ubiquitin specific peptidase 39	dynein axonemal assembly factor 5
Structure			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex U4/U6 X U5 Tri-snRNP Complex	Nucleolus Cytoplasm Cytosol Microtubule Cytoskeleton Motile Cilium Mitotic Spindle Dynein Axonemal Particle
	Molecular Function	Cysteine-type Deubiquitinase Activity Protein Binding Zinc Ion Binding Hydrolase Activity Metal Ion Binding	Dynein Intermediate Chain Binding
	Biological Process	Spliceosomal Complex Assembly MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing Protein Deubiquitination Cell Division	Cilium Movement Cell Projection Organization Outer Dynein Arm Assembly Inner Dynein Arm Assembly
Pathways		mRNA Splicing - Major Pathway	None
GWAS		Neurofibrillary tangles ( 31497858 )	Cerebrospinal P-tau181p levels ( 28247064 ) Initial pursuit acceleration ( 29064472 ) Retinitis pigmentosa ( 33514863 )
Novel Interactors		1 novel interactors: LMAN2L	6 novel interactors: ADAP1 BUD23 GET4 INTS1 MMP16 OTUD4
Interacting Genes		18 interacting genes: ACVR1 APP CCNB1 CEBPA CHEK2 DNAAF5 FXR2 LRRK2 NFKBIA PFKL SAE1 SIRT7 SRPK2 TRAF6 TRIM25 TRIM39 TRIM5 TRIM8	5 interacting genes: FEZ1 PFKL USP39 WEE2-AS1 ZBTB16
Entrez ID		10713	54919
HPRD ID		07165	07903
Ensembl ID		ENSG00000168883	ENSG00000164818
Uniprot IDs		A0A087X1B2 B3KMG1 B3KPG7 B7Z7L9 Q53GS9	B3KPE2 Q86Y56
PDB IDs		3JCR 6AH0 6QW6 6QX9 8H6E 8H6J 8QOZ 8QP8 8QP9 8QPA 8QPB 8QPE 8QPK 8QXD 8QZS 8R08 8R09 8R0A 8R0B 8RM5 8Y6O	Not available
GO Terms Enriched among Interactors		Positive Regulation Of Macromolecule Metabolic Process Regulation Of Protein Localization Positive Regulation Of Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Intracellular Signal Transduction Response To Stress Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Transferase Activity Protein Homodimerization Activity Positive Regulation Of Defense Response Defense Response Identical Protein Binding Intracellular Signal Transduction Regulation Of Cell Communication Regulation Of Primary Metabolic Process Regulation Of Signaling Suppression Of Viral Release By Host Regulation Of Canonical NF-kappaB Signal Transduction Protein K63-linked Ubiquitination Intracellular Signaling Cassette Host-mediated Suppression Of Symbiont Invasion Protein Modification Process Protein Ubiquitination Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Innate Immune Response Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Protein Modification By Small Protein Conjugation Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Defense Response To Symbiont Defense Response To Other Organism Protein Polyubiquitination Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Signal Transduction Regulation Of Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Viral Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Establishment Of Protein Localization Cellular Response To Stress Regulation Of Defense Response Post-translational Protein Modification Positive Regulation Of Catabolic Process Positive Regulation Of Inflammatory Response Cellular Response To Metal Ion	None