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USP39 and TRAF6
Number of citations of the paper that reports this interaction (PMID
23105109
)
4
Data Source:
BioGRID
(two hybrid)
USP39
TRAF6
Gene Name
ubiquitin specific peptidase 39
TNF receptor-associated factor 6, E3 ubiquitin protein ligase
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Spliceosomal Complex
Nucleus
Nucleolus
Cytoplasm
Mitochondrion
Lipid Particle
Cytosol
Plasma Membrane
Cell Cortex
Cytoplasmic Side Of Plasma Membrane
Endosome Membrane
CD40 Receptor Complex
Protein Complex
Perinuclear Region Of Cytoplasm
Molecular Function
Zinc Ion Binding
Ubiquitinyl Hydrolase Activity
Ubiquitin-protein Transferase Activity
Tumor Necrosis Factor Receptor Binding
Protein Binding
Zinc Ion Binding
Ligase Activity
Protein Kinase Binding
Mitogen-activated Protein Kinase Kinase Kinase Binding
Ubiquitin Conjugating Enzyme Binding
Ubiquitin Protein Ligase Binding
Thioesterase Binding
Histone Deacetylase Binding
Protein Kinase B Binding
Protein N-terminus Binding
Biological Process
Spliceosomal Complex Assembly
MRNA Processing
Ubiquitin-dependent Protein Catabolic Process
Cell Cycle
RNA Splicing
Cell Division
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Activation Of MAPK Activity
Protein Polyubiquitination
Ossification
Neural Tube Closure
Toll-like Receptor Signaling Pathway
Positive Regulation Of T Cell Cytokine Production
MyD88-dependent Toll-like Receptor Signaling Pathway
MyD88-independent Toll-like Receptor Signaling Pathway
Protein Complex Assembly
I-kappaB Kinase/NF-kappaB Signaling
Activation Of NF-kappaB-inducing Kinase Activity
JNK Cascade
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II
Osteoclast Differentiation
Membrane Protein Intracellular Domain Proteolysis
Positive Regulation Of Protein Ubiquitination
Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway
Activation Of Protein Kinase Activity
Positive Regulation Of Interleukin-2 Production
Toll-like Receptor 2 Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
Toll-like Receptor 4 Signaling Pathway
Toll-like Receptor 5 Signaling Pathway
Toll-like Receptor 9 Signaling Pathway
Toll-like Receptor 10 Signaling Pathway
TRIF-dependent Toll-like Receptor Signaling Pathway
Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway
Fc-epsilon Receptor Signaling Pathway
Toll-like Receptor TLR1:TLR2 Signaling Pathway
Toll-like Receptor TLR6:TLR2 Signaling Pathway
T-helper 1 Type Immune Response
Positive Regulation Of T Cell Proliferation
Odontogenesis Of Dentin-containing Tooth
Myeloid Dendritic Cell Differentiation
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of JUN Kinase Activity
Positive Regulation Of Interleukin-12 Biosynthetic Process
Innate Immune Response
Positive Regulation Of Interleukin-6 Biosynthetic Process
Bone Resorption
Positive Regulation Of Osteoclast Differentiation
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Neurotrophin TRK Receptor Signaling Pathway
Cell Development
Positive Regulation Of Smooth Muscle Cell Proliferation
T Cell Receptor Signaling Pathway
Positive Regulation Of T Cell Activation
Regulation Of Immunoglobulin Secretion
Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Positive Regulation Of NF-kappaB Transcription Factor Activity
Stress-activated MAPK Cascade
Protein Autoubiquitination
Nucleotide-binding Oligomerization Domain Containing Signaling Pathway
Interleukin-1-mediated Signaling Pathway
Protein K63-linked Ubiquitination
Response To Interleukin-1
Cellular Response To Lipopolysaccharide
Apoptotic Signaling Pathway
Positive Regulation Of Transcription Regulatory Region DNA Binding
Pathways
NF-kB is activated and signals survival
TRAF6 mediated induction of TAK1 complex
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
IRAK1 recruits IKK complex
Toll Like Receptor TLR1:TLR2 Cascade
FCERI mediated NF-kB activation
Toll Like Receptor 5 (TLR5) Cascade
NOD1/2 Signaling Pathway
MyD88 dependent cascade initiated on endosome
Toll Like Receptor 9 (TLR9) Cascade
IRAK1 recruits IKK complex
activated TAK1 mediates p38 MAPK activation
Regulated proteolysis of p75NTR
IRAK2 mediated activation of TAK1 complex
IRAK2 mediated activation of TAK1 complex
TRIF-mediated TLR3/TLR4 signaling
Toll Like Receptor 2 (TLR2) Cascade
Signaling by Interleukins
TCR signaling
NRIF signals cell death from the nucleus
Toll Like Receptor 4 (TLR4) Cascade
Toll Like Receptor 3 (TLR3) Cascade
Fc epsilon receptor (FCERI) signaling
Interleukin-1 signaling
Adaptive Immune System
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
Downstream TCR signaling
p75NTR recruits signalling complexes
Toll Like Receptor 7/8 (TLR7/8) Cascade
Toll Like Receptor TLR6:TLR2 Cascade
Activated TLR4 signalling
MyD88 cascade initiated on plasma membrane
p75NTR signals via NF-kB
MyD88:Mal cascade initiated on plasma membrane
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
Innate Immune System
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
Signalling by NGF
Cell death signalling via NRAGE, NRIF and NADE
IKK complex recruitment mediated by RIP1
MAP kinase activation in TLR cascade
Cytokine Signaling in Immune system
p75 NTR receptor-mediated signalling
MyD88-independent cascade
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
Toll-Like Receptors Cascades
Toll Like Receptor 10 (TLR10) Cascade
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
TRAF6 mediated IRF7 activation
TRAF6 mediated NF-kB activation
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
Drugs
Diseases
GWAS
Protein-Protein Interactions
11 interactors:
ACVR1
APP
SAE1
SP1
SRPK1
TRAF6
TRIM25
TRIM26
TRIM39
TRIM5
TRIM8
144 interactors:
ABL1
APP
ATM
ATP6V1E1
ATXN3
BECN1
BMPR1B
CALCOCO2
CASP8
CAV1
CBL
CD40
CYLD
ECSIT
EDA2R
EDARADD
FHL2
FYN
GTF2I
HIF1A
HSPA4
IKBKG
IL17RB
IRAK1
IRAK2
IRAK3
IRAK4
IRF5
IRF7
IRF8
JAK2
KCNQ1
MALT1
MAP2K1
MAP2K6
MAP2K7
MAP3K11
MAP3K14
MAP3K3
MAP3K5
MAP3K7
MAP3K8
MAPK14
MAPK8
MAPT
MAST2
MAVS
MBP
MCL1
MEOX2
MTOR
NGFR
NGFRAP1
NTRK1
NTRK2
NUMBL
OTUB1
OTUB2
OTUD7B
PELI3
PINK1
PLEKHF2
PLEKHO1
POLI
PPP4C
PRKCZ
PSMB5
PSMC1
PSMC2
PSMC3
PSMD1
PSMD12
PSMD13
PSMD6
PSMD7
PTPN6
RIPK2
RNF114
SIGIRR
SPHK1
SPOP
SQSTM1
SRC
STAMBP
STRADB
STUB1
SYK
TAB1
TAB2
TAB3
TAX1BP1
TDP2
TGFBR1
TICAM1
TICAM2
TIFA
TIRAP
TLR3
TMEM189-UBE2V1
TNFAIP3
TNFRSF11A
TNFRSF13B
TNFRSF19
TNFSF11
TRAF1
TRAF2
TRAF3IP1
TRAF3IP2
TRAF4
TRAF5
TRAF7
TRAFD1
TRAM1
TRIM17
TRIM25
TRIM37
UBB
UBE2D1
UBE2D2
UBE2D3
UBE2D4
UBE2E1
UBE2I
UBE2L3
UBE2N
UBE2V1
UBOX5
UEVLD
USP1
USP15
USP2
USP21
USP39
USP4
USP5
USP7
VPS52
XIAP
YBX1
YES1
ZFAND5
ZMYND11
ZNF675
ZRANB1
Entrez ID
10713
7189
HPRD ID
07165
03833
Ensembl ID
ENSG00000168883
Uniprot IDs
B3KMG1
B7Z7L9
Q53GS9
Q9Y4K3
PDB IDs
1LB4
1LB5
1LB6
2ECI
2JMD
3HCS
3HCT
3HCU
Enriched GO Terms of Interacting Partners
?
Negative Regulation Of Viral Release From Host Cell
Regulation Of Viral Process
Negative Regulation Of Viral Entry Into Host Cell
Regulation Of Viral Entry Into Host Cell
Negative Regulation Of Viral Process
Regulation Of Viral Release From Host Cell
Defense Response
Innate Immune Response
Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Protein Ubiquitination
Protein Modification By Small Protein Conjugation
Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Positive Regulation Of NF-kappaB Transcription Factor Activity
Interferon-gamma-mediated Signaling Pathway
Immune Response
Cellular Response To Interferon-gamma
Immune System Process
Cellular Protein Modification Process
Response To Interferon-gamma
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Cytokine-mediated Signaling Pathway
Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Regulation Of Metabolic Process
Negative Regulation Of Locomotion
Cellular Response To Cytokine Stimulus
Regulation Of Signal Transduction
Cellular Response To Organic Substance
Negative Regulation Of Activin Receptor Signaling Pathway
Positive Regulation Of Signal Transduction
Cellular Protein Metabolic Process
Response To Cytokine
Regulation Of Signaling
Cell Surface Receptor Signaling Pathway
Regulation Of RNA Metabolic Process
Response To Stress
Regulation Of Gene Expression
Regulation Of Nitrogen Compound Metabolic Process
Response To Organic Substance
Regulation Of Lipopolysaccharide-mediated Signaling Pathway
Atrial Septum Development
Signal Transduction
Regulation Of Activin Receptor Signaling Pathway
Protein Metabolic Process
Viral Process
Signaling
Cell Communication
Protein K63-linked Ubiquitination
Regulation Of Transcription, DNA-templated
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Positive Regulation Of Signal Transduction
Regulation Of Signal Transduction
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Signaling
Regulation Of Protein Metabolic Process
Positive Regulation Of Cellular Protein Metabolic Process
Positive Regulation Of Transferase Activity
Positive Regulation Of Protein Modification Process
Regulation Of Cellular Protein Metabolic Process
Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Positive Regulation Of Protein Metabolic Process
Intracellular Signal Transduction
Cellular Protein Modification Process
Pattern Recognition Receptor Signaling Pathway
Innate Immune Response-activating Signal Transduction
Toll-like Receptor 4 Signaling Pathway
Cell Communication
Signal Transduction
Signaling
Immune System Process
Activation Of Innate Immune Response
Regulation Of Intracellular Signal Transduction
Cellular Response To Stimulus
Regulation Of Innate Immune Response
Toll-like Receptor Signaling Pathway
Response To Stress
Positive Regulation Of NF-kappaB Transcription Factor Activity
Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Positive Regulation Of Innate Immune Response
Response To Stimulus
Regulation Of Apoptotic Process
Positive Regulation Of Cellular Metabolic Process
Defense Response
TRIF-dependent Toll-like Receptor Signaling Pathway
Immune Response-regulating Signaling Pathway
MyD88-independent Toll-like Receptor Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
Regulation Of Cell Death
Response To Organic Substance
Cell Death
Death
Cellular Protein Metabolic Process
Innate Immune Response
Activation Of Protein Kinase Activity
Programmed Cell Death
Cellular Response To Organic Substance
Cellular Response To Stress
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Regulation Of Immune System Process
Tagcloud
?
adhesion
affinity
bind
cd40
cd40ct
cytoplasmic
dispensable
dominantly
extensive
icam
ikappabalpha
implicated
incapable
intercellular
jak3
kappab
mediators
molecule
much
mutants
necrosis
residues
strongly
tail
traf2
traf3
traf5
transduction
Tagcloud (Difference)
?
adhesion
affinity
bind
cd40
cd40ct
cytoplasmic
dispensable
dominantly
extensive
icam
ikappabalpha
implicated
incapable
intercellular
jak3
kappab
mediators
molecule
much
mutants
necrosis
residues
strongly
tail
traf2
traf3
traf5
transduction
Tagcloud (Intersection)
?