USP39 and SIRT7

Number of citations: 43 (PubMedID 32711345)
Data Source: BioGRID (enzymatic study)

		USP39	SIRT7
Name		ubiquitin specific peptidase 39	sirtuin 7
Structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex U4/U6 X U5 Tri-snRNP Complex	Chromatin Nucleus Nucleoplasm Chromosome Nucleolus Nucleolus Organizer Region Cytoplasm Nuclear Speck Site Of Double-strand Break
	Molecular Function	Cysteine-type Deubiquitinase Activity Protein Binding Zinc Ion Binding Hydrolase Activity Metal Ion Binding	Chromatin Binding Protein Binding Protein Methyltransferase Activity Transferase Activity Hydrolase Activity NAD-dependent Protein Lysine Deacetylase Activity Protein-succinyllysine Desuccinylase Activity Metal Ion Binding Protein-glutaryllysine Deglutarylase Activity NAD+ Binding Histone H3K18 Deacetylase Activity, NAD-dependent NAD-dependent Protein-lysine Depropionylase Activity
	Biological Process	Spliceosomal Complex Assembly MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing Protein Deubiquitination Cell Division	Negative Regulation Of Transcription By RNA Polymerase II Osteoblast Differentiation Regulation Of Gluconeogenesis DNA Repair Regulation Of DNA Repair Chromatin Organization Regulation Of Transcription By RNA Polymerase II Protein Deacetylation DNA Damage Response Homologous Chromosome Pairing At Meiosis RRNA Transcription Transposable Element Silencing Regulation Of Mitochondrion Organization Negative Regulation Of Protein Ubiquitination Epigenetic Regulation Of Gene Expression Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Gluconeogenesis Negative Regulation Of Gene Expression, Epigenetic Transcription Initiation-coupled Chromatin Remodeling Positive Regulation Of Transcription By RNA Polymerase I Regulation Of Protein Export From Nucleus Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Protein Deglutarylation R-loop Processing Protein Depropionylation DNA Repair-dependent Chromatin Remodeling Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I Positive Regulation Of RRNA Processing
Pathways		mRNA Splicing - Major Pathway	None
GWAS		Neurofibrillary tangles ( 31497858 )	No GWAS studies recorded
Interacting Genes		18 interacting genes: ACVR1 APP CCNB1 CEBPA CHEK2 DNAAF5 FXR2 LRRK2 NFKBIA PFKL SAE1 SIRT7 SRPK2 TRAF6 TRIM25 TRIM39 TRIM5 TRIM8	14 interacting genes: APP H2AC20 H2BC21 H3C1 H4C1 KAT2B MAGED1 NPM1 POLR1E PPARG RRP9 USP17L2 USP39 WDR77
Entrez ID		10713	51547
HPRD ID		07165	12094
Ensembl ID		ENSG00000168883	ENSG00000187531
Uniprot IDs		A0A087X1B2 B3KMG1 B3KPG7 B7Z7L9 Q53GS9	Q9NRC8
PDB IDs		3JCR 6AH0 6QW6 6QX9 8H6E 8H6J 8QOZ 8QP8 8QP9 8QPA 8QPB 8QPE 8QPK 8QXD 8QZS 8R08 8R09 8R0A 8R0B 8RM5 8Y6O	5IQZ 6G0S 9GMK 9GMR
GO Terms Enriched among Interactors		Positive Regulation Of Macromolecule Metabolic Process Regulation Of Protein Localization Positive Regulation Of Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Intracellular Signal Transduction Response To Stress Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Transferase Activity Protein Homodimerization Activity Positive Regulation Of Defense Response Defense Response Identical Protein Binding Intracellular Signal Transduction Regulation Of Cell Communication Regulation Of Primary Metabolic Process Regulation Of Signaling Suppression Of Viral Release By Host Regulation Of Canonical NF-kappaB Signal Transduction Protein K63-linked Ubiquitination Intracellular Signaling Cassette Host-mediated Suppression Of Symbiont Invasion Protein Modification Process Protein Ubiquitination Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Innate Immune Response Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Protein Modification By Small Protein Conjugation Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Defense Response To Symbiont Defense Response To Other Organism Protein Polyubiquitination Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Signal Transduction Regulation Of Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Viral Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Establishment Of Protein Localization Cellular Response To Stress Regulation Of Defense Response Post-translational Protein Modification Positive Regulation Of Catabolic Process Positive Regulation Of Inflammatory Response Cellular Response To Metal Ion	Chromatin Remodeling Protein-DNA Complex Assembly Structural Constituent Of Chromatin Nucleus Chromatin Organization Protein-containing Complex Assembly Nucleosome Assembly Nucleosome Nucleosome Organization Protein-containing Complex Organization Protein Heterodimerization Activity Negative Regulation Of Cell Population Proliferation Protein-containing Complex Negative Regulation Of Centrosome Duplication Epigenetic Regulation Of Gene Expression Transcription Coactivator Activity Negative Regulation Of Gene Expression Regulation Of Cell Population Proliferation Positive Regulation Of Glycolytic Process Nucleoplasm Regulation Of Centriole Replication Negative Regulation Of MiRNA Transcription Cellular Component Assembly Positive Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Epithelial Cell Proliferation Regulation Of Protein Localization To Nucleus Positive Regulation Of Small Molecule Metabolic Process Positive Regulation Of ATP Metabolic Process Regulation Of RNA Splicing DNA-binding Transcription Factor Binding Positive Regulation Of Fatty Acid Metabolic Process Chromatin Binding Regulation Of Protein Localization Positive Regulation Of Gene Expression, Epigenetic Negative Regulation Of Protein Localization To Nucleus Amyloid-beta Complex Growth Cone Lamellipodium DNA Binding Regulation Of Response To Calcium Ion Regulation Of Glycolytic Process Amylin Binding Positive Regulation Of Toll Signaling Pathway Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Programmed Cell Death Regulation Of MRNA Stability Involved In Cellular Response To UV Regulation Of EIF2 Alpha Phosphorylation By DsRNA Regulation Of Centrosome Duplication RNA Polymerase I General Transcription Initiation Factor Binding Oocyte Axis Specification Macromolecule Metabolic Process