USP39 and SAE1

Number of citations of the paper that reports this interaction (PMID 25027693)
0

Data Source:
BioGRID (enzymatic study)

		USP39	SAE1
Gene Name		ubiquitin specific peptidase 39	SUMO1 activating enzyme subunit 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Spliceosomal Complex	Nucleus Nucleoplasm Cytosol SUMO Activating Enzyme Complex Intracellular Membrane-bounded Organelle
	Molecular Function	Zinc Ion Binding Ubiquitinyl Hydrolase Activity	Ubiquitin Activating Enzyme Activity Protein Binding Protein C-terminus Binding Enzyme Activator Activity SUMO Activating Enzyme Activity ATP-dependent Protein Binding Protein Heterodimerization Activity
	Biological Process	Spliceosomal Complex Assembly MRNA Processing Ubiquitin-dependent Protein Catabolic Process Cell Cycle RNA Splicing Cell Division	Regulation Of Mitotic Cell Cycle Protein Ubiquitination Protein Sumoylation SMT3-dependent Protein Catabolic Process Positive Regulation Of Catalytic Activity Post-translational Protein Modification Cellular Protein Metabolic Process
Pathways			Post-translational protein modification SUMOylation SUMO is conjugated to E1 (UBA2:SAE1) Processing and activation of SUMO SUMO is transferred from E1 to E2 (UBE2I, UBC9)
Drugs
Diseases
GWAS			Multiple sclerosis ( 21833088)
Protein-Protein Interactions		11 interactors: ACVR1 APP SAE1 SP1 SRPK1 TRAF6 TRIM25 TRIM26 TRIM39 TRIM5 TRIM8	15 interactors: APP ETV4 HSPA1A HSPA2 IL3RA PTK2 RANBP2 SP100 SUMO1 SUMO2 SUMO3 UBA2 UBE2E3 UBE2I USP39
Entrez ID		10713	10055
HPRD ID		07165	18010
Ensembl ID		ENSG00000168883	ENSG00000142230
Uniprot IDs		B3KMG1 B7Z7L9 Q53GS9	Q9UBE0
PDB IDs			1Y8Q 1Y8R 3KYC 3KYD
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Viral Release From Host Cell Regulation Of Viral Process Negative Regulation Of Viral Entry Into Host Cell Regulation Of Viral Entry Into Host Cell Negative Regulation Of Viral Process Regulation Of Viral Release From Host Cell Defense Response Innate Immune Response Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Protein Ubiquitination Protein Modification By Small Protein Conjugation Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Interferon-gamma-mediated Signaling Pathway Immune Response Cellular Response To Interferon-gamma Immune System Process Cellular Protein Modification Process Response To Interferon-gamma Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Cytokine-mediated Signaling Pathway Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Metabolic Process Negative Regulation Of Locomotion Cellular Response To Cytokine Stimulus Regulation Of Signal Transduction Cellular Response To Organic Substance Negative Regulation Of Activin Receptor Signaling Pathway Positive Regulation Of Signal Transduction Cellular Protein Metabolic Process Response To Cytokine Regulation Of Signaling Cell Surface Receptor Signaling Pathway Regulation Of RNA Metabolic Process Response To Stress Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Response To Organic Substance Regulation Of Lipopolysaccharide-mediated Signaling Pathway Atrial Septum Development Signal Transduction Regulation Of Activin Receptor Signaling Pathway Protein Metabolic Process Viral Process Signaling Cell Communication Protein K63-linked Ubiquitination Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process	Protein Sumoylation Peptidyl-lysine Modification Protein Modification By Small Protein Conjugation Post-translational Protein Modification Cellular Protein Metabolic Process Positive Regulation Of Proteolysis Peptidyl-amino Acid Modification Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Cellular Protein Catabolic Process Positive Regulation Of Metabolic Process Protein Metabolic Process Positive Regulation Of Protein Catabolic Process Negative Regulation Of Inclusion Body Assembly Cellular Protein Modification Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Proteolysis Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Inclusion Body Assembly Cellular Metabolic Process Protein Refolding Regulation Of Protein Catabolic Process Regulation Of Cellular Protein Metabolic Process Cytokine-mediated Signaling Pathway Regulation Of Metabolic Process Protein Localization To Nucleus Regulation Of Protein Metabolic Process Regulation Of Protein Ubiquitination Viral Process Cellular Response To Cytokine Stimulus Negative Regulation Of DNA Binding Response To Organic Substance Regulation Of Growth Regulation Of Binding Synaptonemal Complex Disassembly Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Involved In G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of SUMO Transferase Activity Protein Folding Response To Cytokine Nuclear Envelope Organization Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Kinase Activity Regulation Of Synapse Structure Or Activity Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Innate Immune Response SMT3-dependent Protein Catabolic Process
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