USP39 and TRIM39

Number of citations of the paper that reports this interaction (PubMedID 23105109)
42

Data Source:
BioGRID (two hybrid)

		USP39	TRIM39
Description		ubiquitin specific peptidase 39	tripartite motif containing 39
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex U4/U6 X U5 Tri-snRNP Complex	Nucleus Cytoplasm Mitochondrion Cytosol
	Molecular Function	Cysteine-type Deubiquitinase Activity Protein Binding Zinc Ion Binding Hydrolase Activity Metal Ion Binding	Protein Binding Zinc Ion Binding Transferase Activity Identical Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Spliceosomal Complex Assembly MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing Protein Deubiquitination Cell Division	Apoptotic Process Mitotic G2 DNA Damage Checkpoint Signaling Regulation Of Gene Expression Protein Ubiquitination Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Canonical NF-kappaB Signal Transduction Innate Immune Response Protein Stabilization Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Apoptotic Signaling Pathway
Pathways		mRNA Splicing - Major Pathway	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Neurofibrillary tangles ( 31497858)	Anxiety ( 33859377) Asthma (adult onset) ( 31036433) Asthma (childhood onset) ( 31036433) Autism spectrum disorder or schizophrenia ( 28540026) Cutaneous lupus erythematosus ( 25827949) Neuroticism ( 29255261)
Interacting Genes		18 interacting genes: ACVR1 APP CCNB1 CEBPA CHEK2 DNAAF5 FXR2 LRRK2 NFKBIA PFKL SAE1 SIRT7 SRPK2 TRAF6 TRIM25 TRIM39 TRIM5 TRIM8	61 interacting genes: APP CACTIN CCNC DCUN1D1 DCX DIP2A EIF4A2 EPHB6 GAMT HINFP KDM1A LMNA LNX1 LXN MED18 MNAT1 MTURN OTUB2 OTUD6A PDLIM5 PLCD4 POLI PRPF3 PSMA6 PSMB1 PSMD9 RAD23A RECK RNF166 SMCO3 TP53 TRIM17 TRIM21 TRIM8 TTC32 UBAC1 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2K UBE2L3 UBE2N UBE2V1 UBE2W UBL5 UBTD1 UBTD2 UBXN1 UBXN6 UBXN7 USP2 USP39 USP5 WDFY3 ZKSCAN4 ZNF26
Entrez ID		10713	56658
HPRD ID		07165	09298
Ensembl ID		ENSG00000168883	ENSG00000204599
Uniprot IDs		A0A087X1B2 B3KMG1 B3KPG7 B7Z7L9 Q53GS9	A0A024RCP5 Q9HCM9
PDB IDs		3JCR 6AH0 6QW6 6QX9 8H6E 8H6J 8QOZ 8QP8 8QP9 8QPA 8QPB 8QPE 8QPK 8QXD 8QZS 8R08 8R09 8R0A 8R0B 8RM5 8Y6O	2DID 2DIF 2ECJ
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Macromolecule Metabolic Process Regulation Of Protein Localization Positive Regulation Of Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Intracellular Signal Transduction Response To Stress Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Transferase Activity Protein Homodimerization Activity Positive Regulation Of Defense Response Defense Response Identical Protein Binding Intracellular Signal Transduction Regulation Of Cell Communication Regulation Of Primary Metabolic Process Regulation Of Signaling Suppression Of Viral Release By Host Regulation Of Canonical NF-kappaB Signal Transduction Protein K63-linked Ubiquitination Intracellular Signaling Cassette Host-mediated Suppression Of Symbiont Invasion Protein Modification Process Protein Ubiquitination Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Innate Immune Response Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Protein Modification By Small Protein Conjugation Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Defense Response To Symbiont Defense Response To Other Organism Protein Polyubiquitination Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Signal Transduction Regulation Of Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Viral Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Establishment Of Protein Localization Cellular Response To Stress Regulation Of Defense Response Post-translational Protein Modification Positive Regulation Of Catabolic Process Positive Regulation Of Inflammatory Response Cellular Response To Metal Ion	Ubiquitin Conjugating Enzyme Activity Post-translational Protein Modification Protein Modification By Small Protein Conjugation Protein Ubiquitination Protein Polyubiquitination Proteolysis Involved In Protein Catabolic Process Ubiquitin-protein Transferase Activity Protein Metabolic Process Modification-dependent Protein Catabolic Process Proteolysis Protein Modification Process Ubiquitin-dependent Protein Catabolic Process Macromolecule Metabolic Process Protein K48-linked Ubiquitination Macromolecule Catabolic Process Protein Monoubiquitination Protein K11-linked Ubiquitination Protein K63-linked Ubiquitination Catabolic Process Nucleus Protein Binding Nucleoplasm Proteasomal Protein Catabolic Process Ubiquitin Protein Ligase Binding Ubiquitin Binding Regulation Of Post-translational Protein Modification Ubiquitin Ligase Complex Regulation Of Protein Ubiquitination Positive Regulation Of Post-translational Protein Modification Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Catabolic Process Regulation Of Protein Modification Process Cysteine-type Deubiquitinase Activity Transferase Activity Protein Deubiquitination Positive Regulation Of Protein Polyubiquitination UBC13-MMS2 Complex Ubiquitin Protein Ligase Activity Positive Regulation Of Protein Ubiquitination Positive Regulation Of Protein Modification Process Protein Modification By Small Protein Removal Regulation Of Protein Metabolic Process Negative Regulation Of Protein Deubiquitination ISG15 Transferase Activity Ubiquitin Conjugating Enzyme Complex DNA Repair Cytosol Protein K6-linked Ubiquitination Protein Autoubiquitination Positive Regulation Of Protein Metabolic Process
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?