USP39 and TRIM8

Number of citations of the paper that reports this interaction (PubMedID 23105109)
42

Data Source:
BioGRID (two hybrid)

		USP39	TRIM8
Description		ubiquitin specific peptidase 39	tripartite motif containing 8
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex U4/U6 X U5 Tri-snRNP Complex	Nucleus Cytoplasm Cytosol Nuclear Body PML Body
	Molecular Function	Cysteine-type Deubiquitinase Activity Protein Binding Zinc Ion Binding Hydrolase Activity Metal Ion Binding	Transcription Coactivator Activity Protein Binding Zinc Ion Binding Transferase Activity Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Spliceosomal Complex Assembly MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing Protein Deubiquitination Cell Division	Immune System Process Canonical NF-kappaB Signal Transduction Positive Regulation Of Autophagy Protein Ubiquitination Stem Cell Population Maintenance Negative Regulation Of Viral Transcription Positive Regulation Of Canonical NF-kappaB Signal Transduction Suppression Of Viral Release By Host Innate Immune Response Positive Regulation Of DNA-templated Transcription Host-mediated Suppression Of Symbiont Invasion Protein K63-linked Ubiquitination Positive Regulation Of Protein Localization To Nucleus
Pathways		mRNA Splicing - Major Pathway	Interferon gamma signaling
Drugs
Diseases
GWAS		Neurofibrillary tangles ( 31497858)	Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Body mass index ( 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index in physically active individuals ( 28448500) Brain morphology (MOSTest) ( 32665545) Feeling nervous ( 29500382) Hip circumference adjusted for BMI ( 34021172) Prostate cancer ( 23535732) Pulse pressure ( 30578418) Refractive error ( 32231278) Schizophrenia ( 25056061 30285260) Serum alkaline phosphatase levels ( 33547301) Smoking status (ever vs never smokers) ( 30643258) Ulcerative colitis ( 26192919) Waist circumference adjusted for body mass index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		18 interacting genes: ACVR1 APP CCNB1 CEBPA CHEK2 DNAAF5 FXR2 LRRK2 NFKBIA PFKL SAE1 SIRT7 SRPK2 TRAF6 TRIM25 TRIM39 TRIM5 TRIM8	64 interacting genes: BRAP CATSPER1 CBL CCNH DCUN1D1 ESR1 FAM124B HOXA1 ITSN1 LNX1 LONRF1 MAGEC2 MKRN3 MSL2 MTURN NRIP1 NUDT10 OTUB2 PCGF5 RAD18 RAD23A RC3H2 RCHY1 RNF111 RNF113A RNF138 RNF141 RNF168 RNF181 RNF41 RNF7 SIAH1 SOCS1 TICAM1 TNFAIP3 TNPO2 TNS2 TRAF5 TRIM15 TRIM2 TRIM21 TRIM24 TRIM25 TRIM39 TRIM43 TRIM47 TRIM9 UBASH3A UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2L6 UBE2V1 UBE2W UBXN7 UHRF2 USP2 USP21 USP39 USP5 USP7 XIAP YOD1
Entrez ID		10713	81603
HPRD ID		07165	06934
Ensembl ID		ENSG00000168883	ENSG00000171206
Uniprot IDs		A0A087X1B2 B3KMG1 B3KPG7 B7Z7L9 Q53GS9	Q9BZR9
PDB IDs		3JCR 6AH0 6QW6 6QX9 8H6E 8H6J 8QOZ 8QP8 8QP9 8QPA 8QPB 8QPE 8QPK 8QXD 8QZS 8R08 8R09 8R0A 8R0B 8RM5 8Y6O
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Macromolecule Metabolic Process Regulation Of Protein Localization Positive Regulation Of Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Intracellular Signal Transduction Response To Stress Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Transferase Activity Protein Homodimerization Activity Positive Regulation Of Defense Response Defense Response Identical Protein Binding Intracellular Signal Transduction Regulation Of Cell Communication Regulation Of Primary Metabolic Process Regulation Of Signaling Suppression Of Viral Release By Host Regulation Of Canonical NF-kappaB Signal Transduction Protein K63-linked Ubiquitination Intracellular Signaling Cassette Host-mediated Suppression Of Symbiont Invasion Protein Modification Process Protein Ubiquitination Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Innate Immune Response Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Protein Modification By Small Protein Conjugation Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Defense Response To Symbiont Defense Response To Other Organism Protein Polyubiquitination Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Signal Transduction Regulation Of Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Viral Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Establishment Of Protein Localization Cellular Response To Stress Regulation Of Defense Response Post-translational Protein Modification Positive Regulation Of Catabolic Process Positive Regulation Of Inflammatory Response Cellular Response To Metal Ion	Post-translational Protein Modification Protein Ubiquitination Protein Modification By Small Protein Conjugation Ubiquitin Protein Ligase Activity Protein Modification Process Ubiquitin-protein Transferase Activity Protein Metabolic Process Protein Polyubiquitination Zinc Ion Binding Proteolysis Transferase Activity Proteolysis Involved In Protein Catabolic Process Macromolecule Metabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Macromolecule Catabolic Process Protein Autoubiquitination Metal Ion Binding Ubiquitin Conjugating Enzyme Activity Protein Monoubiquitination Cysteine-type Deubiquitinase Activity Catabolic Process Protein Deubiquitination Protein Catabolic Process Nucleus Protein Modification By Small Protein Removal Proteasomal Protein Catabolic Process Regulation Of Post-translational Protein Modification Positive Regulation Of Post-translational Protein Modification Regulation Of Protein Ubiquitination Ubiquitin Binding Protein K48-linked Ubiquitination Positive Regulation Of Protein Ubiquitination DNA Damage Response Nucleoplasm Protein K63-linked Ubiquitination Regulation Of Signal Transduction Cysteine-type Peptidase Activity Cellular Response To Stress Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Deubiquitination DNA Repair Cytoplasm Cytosol Regulation Of Signaling Regulation Of Cell Communication Regulation Of Intracellular Signal Transduction Protein K11-linked Deubiquitination Regulation Of Protein Stability Protein K11-linked Ubiquitination
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