ZSCAN21 and CLK2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ZSCAN21	CLK2
Description		zinc finger and SCAN domain containing 21	CDC like kinase 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus	Nucleus Nucleoplasm Nuclear Body Nuclear Speck
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Identical Protein Binding Protein Serine Kinase Activity
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Male Meiosis I Spermatogenesis Cell Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Meiotic Cell Cycle	Protein Phosphorylation Response To Ionizing Radiation Regulation Of RNA Splicing Negative Regulation Of Gluconeogenesis Protein Autophosphorylation
Pathways
Drugs			Fostamatinib
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Refractive error ( 32231278) Subcortical volume (MOSTest) ( 32665545)	Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		25 interacting genes: APP BRCA1 CAVIN1 CEP70 CLK2 DVL3 KRT40 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-3 OGT PICK1 SCAND1 TRIM41 ZKSCAN7 ZNF396 ZNF446 ZNF483 ZNF496 ZNF837 ZSCAN12 ZSCAN22	62 interacting genes: AKT1 AP2M1 ASPSCR1 CACTIN CLASRP CLK1 CLK3 CPSF7 DDIT4L ECE1 EHHADH GMCL1 GTPBP2 KLHL2 LNX1 LUC7L LUZP4 MRPL2 MRPL4 NIP7 NXF1 PATL1 PRM1 PRPF38A PRPF6 PTPN1 RBM39 RBM6 RNF8 RNPS1 RSRP1 SDCBP SNRNP27 SRPK2 SRRM1 SRSF1 SRSF10 SRSF8 TACC2 TRIM27 TRIM50 U2AF1 UBE2I UBL5 YTHDC1 YTHDF1 YWHAG ZNF136 ZNF263 ZNF317 ZNF394 ZNF398 ZNF436 ZNF440 ZNF473 ZNF491 ZNF558 ZNF764 ZNF768 ZNF837 ZRSR2 ZSCAN21
Entrez ID		7589	1196
HPRD ID		03162	04289
Ensembl ID		ENSG00000166529	ENSG00000176444
Uniprot IDs		G3V0F4 Q9Y5A6	A8K7I0 B1AVT0 B7Z8N6 P49760
PDB IDs			3NR9 5UNP 6FYI 6FYK 6FYL 6KHE
Enriched GO Terms of Interacting Partners?		Keratin Filament Intermediate Filament Identical Protein Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Zinc Ion Binding Regulation Of RNA Metabolic Process DNA Binding	MRNA Metabolic Process MRNA Processing RNA Splicing MRNA Splicing, Via Spliceosome RNA Binding RNA Splicing, Via Transesterification Reactions RS Domain Binding RNA Processing Nucleus RNA Metabolic Process Nuclear Speck Regulation Of RNA Splicing Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing Nucleic Acid Metabolic Process Regulation Of MRNA Metabolic Process Spliceosomal Complex Regulation Of RNA Metabolic Process Zinc Ion Binding Protein-RNA Complex Assembly Nucleic Acid Binding Regulation Of Gene Expression Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Nucleoplasm Regulation Of Nucleobase-containing Compound Metabolic Process MRNA Binding Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Splice Site Recognition Macromolecule Metabolic Process Catalytic Step 2 Spliceosome Regulation Of Metabolic Process Spliceosomal Complex Assembly Mammalian Oogenesis Stage Protein Binding MRNA Alternative Polyadenylation DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein K6-linked Ubiquitination Protein Serine/threonine/tyrosine Kinase Activity Pre-mRNA 3'-splice Site Binding U2AF Complex MRNA 3'-end Processing RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA Binding Positive Regulation Of Translational Initiation Regulation Of Transcription By RNA Polymerase II Negative Regulation Of PERK-mediated Unfolded Protein Response N6-methyladenosine-containing RNA Reader Activity
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