TYRO3 and AXL

Number of citations of the paper that reports this interaction (PubMedID 15964779)
0

Data Source:
BioGRID (two hybrid)

		TYRO3	AXL
Description		TYRO3 protein tyrosine kinase	AXL receptor tyrosine kinase
Image
GO Annotations	Cellular Component	Nucleus Nuclear Envelope Endoplasmic Reticulum Membrane Plasma Membrane Cell Surface Membrane Receptor Complex	Extracellular Space Plasma Membrane Cell Surface Actin Cytoskeleton Membrane Receptor Complex Extracellular Exosome
	Molecular Function	Nucleotide Binding Virus Receptor Activity Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Phosphatidylinositol 3-kinase Binding	Nucleotide Binding Virus Receptor Activity Phosphatidylserine Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity
	Biological Process	Neuron Migration Natural Killer Cell Differentiation Phagocytosis Cell Adhesion Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Neuropeptide Signaling Pathway Spermatogenesis Nervous System Development Cell Migration Forebrain Cell Migration Platelet Activation Secretion By Cell Negative Regulation Of Toll-like Receptor Signaling Pathway Substrate Adhesion-dependent Cell Spreading Ovulation Cycle Apoptotic Cell Clearance Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Innate Immune Response Lymphocyte Activation Symbiont Entry Into Host Cell Negative Regulation Of Inflammatory Response Negative Regulation Of Lymphocyte Activation Neuron Apoptotic Process Establishment Of Localization In Cell Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Vagina Development Neuron Cellular Homeostasis Platelet Aggregation Positive Regulation Of Viral Life Cycle	Neuron Migration Natural Killer Cell Differentiation Negative Regulation Of Cytokine Production Positive Regulation Of Cytokine-mediated Signaling Pathway Blood Vessel Remodeling Immune System Process Phagocytosis Apoptotic Process Inflammatory Response Signal Transduction Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Spermatogenesis Nervous System Development Positive Regulation Of Signal Transduction Negative Regulation Of Macrophage Cytokine Production Cell Migration Forebrain Cell Migration Cell Differentiation Platelet Activation Negative Regulation Of Type II Interferon Production Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Natural Killer Cell Differentiation Secretion By Cell Erythrocyte Homeostasis Substrate Adhesion-dependent Cell Spreading Cellular Response To Interferon-alpha Ovulation Cycle Negative Regulation Of Apoptotic Process Apoptotic Cell Clearance Negative Regulation Of Neuron Apoptotic Process Innate Immune Response Lymphocyte Activation Symbiont Entry Into Host Cell Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell Maturation Positive Regulation Of Pinocytosis Regulation Of Lymphocyte Activation Negative Regulation Of Lymphocyte Activation Neuron Apoptotic Process Establishment Of Localization In Cell Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Vagina Development Cellular Response To Lipopolysaccharide Dendritic Cell Differentiation Neutrophil Clearance Mononuclear Cell Differentiation Positive Regulation Of Viral Life Cycle Negative Regulation Of Dendritic Cell Apoptotic Process
Pathways			VEGFA-VEGFR2 Pathway
Drugs		Fostamatinib	Fostamatinib Gilteritinib
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Blood protein levels ( 30072576) HDL cholesterol levels ( 32203549) Metabolic syndrome ( 31589552) Microalbuminuria ( 31511532) Red blood cell count ( 32888494) Systemic lupus erythematosus ( 24871463) Urinary albumin-to-creatinine ratio ( 31511532 31630189)	Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) HDL cholesterol ( 31170924) Heel bone mineral density ( 30598549) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red blood cell count ( 32888494) Triglyceride levels ( 32154731 32203549)
Interacting Genes		27 interacting genes: A2M APOE AXL CTDSP1 CTDSP2 ERBB2 FYN GAS6 IKBKG KLK4 KRT40 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP4-2 KRTAP5-9 KRTAP9-2 LNX1 MDFI MGAT5B PIK3R1 PROS1 SRC TNIP1 VWC2L YES1	24 interacting genes: ADAM10 CBL EGFR FBXO25 GAS6 GRB2 IL15RA IL2RG LCK MTDH NCK2 PIK3R1 PIK3R2 PIK3R3 PLCG1 PTPN11 RANBP9 SHC1 SHC3 SOCS1 SRC TNS2 TYRO3 UBC
Entrez ID		7301	558
HPRD ID		02641	00171
Ensembl ID		ENSG00000092445	ENSG00000167601
Uniprot IDs		H0YNK6 Q06418	M0R0W6 P30530
PDB IDs		1RHF	2C5D 4RA0 5U6B 5VXZ
Enriched GO Terms of Interacting Partners?		Intermediate Filament Keratin Filament Signaling Receptor Binding Protein Tyrosine Kinase Activity Identical Protein Binding Cellular Response To Platelet-derived Growth Factor Stimulus Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Response To Platelet-derived Growth Factor Negative Regulation Of Immune System Process Regulation Of Immune System Process Negative Regulation Of Inflammatory Response To Antigenic Stimulus Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Dendritic Spine Maintenance Vascular Endothelial Growth Factor Receptor Signaling Pathway ErbB-3 Class Receptor Binding Fc-gamma Receptor Signaling Pathway Leukocyte Migration Cellular Response To Oxygen-containing Compound Regulation Of Cell Activation Negative Regulation Of Multicellular Organismal Process Positive Regulation Of Intracellular Signal Transduction Enzyme-linked Receptor Protein Signaling Pathway Substrate Adhesion-dependent Cell Spreading T Cell Costimulation Non-membrane Spanning Protein Tyrosine Kinase Activity RNA Polymerase II CTD Heptapeptide Repeat Phosphatase Activity Regulation Of Innate Immune Response Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Negative Regulation Of Defense Response Cellular Response To Growth Factor Stimulus Peptidyl-tyrosine Phosphorylation Ephrin Receptor Signaling Pathway Regulation Of ERK1 And ERK2 Cascade Regulation Of Immune Response Negative Regulation Of Dendritic Cell Apoptotic Process Fc Receptor Signaling Pathway Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cell-substrate Adhesion Positive Regulation Of Natural Killer Cell Differentiation Cellular Response To Interferon-alpha Regulation Of Intracellular Signal Transduction Positive Regulation Of Establishment Of Protein Localization Positive Regulation Of Immune System Process Regulation Of Lymphocyte Activation Response To Growth Factor Cellular Response To Transforming Growth Factor Beta Stimulus Phospholipase Activator Activity Platelet Alpha Granule Lumen Positive Regulation Of Lymphocyte Activation	Phosphotyrosine Residue Binding Cell Surface Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Receptor Tyrosine Kinase Binding Leukocyte Activation Cell Activation Neurotrophin TRKA Receptor Binding Mononuclear Cell Differentiation Positive Regulation Of Lymphocyte Activation Regulation Of Lymphocyte Activation Leukocyte Differentiation Positive Regulation Of Cell Activation Immune System Process Positive Regulation Of Immune System Process Signal Transduction Regulation Of Cell Activation Lymphocyte Activation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Signal Transduction Regulation Of Immune System Process Lymphocyte Differentiation Regulation Of Cell Adhesion Regulation Of Intracellular Signal Transduction Positive Regulation Of T Cell Activation 1-phosphatidylinositol-3-kinase Regulator Activity Positive Regulation Of Multicellular Organismal Process Ephrin Receptor Binding Insulin Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Positive Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Multicellular Organismal Process Protein Kinase Binding Regulation Of Cell Communication Regulation Of Signaling Regulation Of Apoptotic Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of MAPK Cascade Intracellular Signal Transduction T Cell Activation Cell Migration Regulation Of Programmed Cell Death Protein Phosphatase Binding Response To Growth Factor Phosphatidylinositol 3-kinase Regulatory Subunit Binding Phosphatidylinositol 3-kinase Complex, Class IA
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