TYRO3 and KLK4

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		TYRO3	KLK4
Description		TYRO3 protein tyrosine kinase	kallikrein related peptidase 4
Image
GO Annotations	Cellular Component	Nucleus Nuclear Envelope Endoplasmic Reticulum Membrane Plasma Membrane Cell Surface Membrane Receptor Complex	Extracellular Region Extracellular Space Secretory Granule
	Molecular Function	Nucleotide Binding Virus Receptor Activity Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Phosphatidylinositol 3-kinase Binding	Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Metal Ion Binding
	Biological Process	Neuron Migration Natural Killer Cell Differentiation Phagocytosis Cell Adhesion Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Neuropeptide Signaling Pathway Spermatogenesis Nervous System Development Cell Migration Forebrain Cell Migration Platelet Activation Secretion By Cell Negative Regulation Of Toll-like Receptor Signaling Pathway Substrate Adhesion-dependent Cell Spreading Ovulation Cycle Apoptotic Cell Clearance Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Innate Immune Response Lymphocyte Activation Symbiont Entry Into Host Cell Negative Regulation Of Inflammatory Response Negative Regulation Of Lymphocyte Activation Neuron Apoptotic Process Establishment Of Localization In Cell Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Vagina Development Neuron Cellular Homeostasis Platelet Aggregation Positive Regulation Of Viral Life Cycle	Proteolysis Extracellular Matrix Disassembly Biomineral Tissue Development Protein Maturation Amelogenesis
Pathways
Drugs		Fostamatinib
Diseases			Amelogenesis imperfecta
GWAS		Apolipoprotein A1 levels ( 32203549) Blood protein levels ( 30072576) HDL cholesterol levels ( 32203549) Metabolic syndrome ( 31589552) Microalbuminuria ( 31511532) Red blood cell count ( 32888494) Systemic lupus erythematosus ( 24871463) Urinary albumin-to-creatinine ratio ( 31511532 31630189)	Celiac disease ( 23936387) Dental caries (decayed, missing and filled tooth surfaces) ( 31533690) Obesity-related traits ( 23251661)
Interacting Genes		27 interacting genes: A2M APOE AXL CTDSP1 CTDSP2 ERBB2 FYN GAS6 IKBKG KLK4 KRT40 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP4-2 KRTAP5-9 KRTAP9-2 LNX1 MDFI MGAT5B PIK3R1 PROS1 SRC TNIP1 VWC2L YES1	3 interacting genes: SERPINA3 SHBG TYRO3
Entrez ID		7301	9622
HPRD ID		02641	04793
Ensembl ID		ENSG00000092445	ENSG00000167749
Uniprot IDs		H0YNK6 Q06418	A0A0C4DFQ5 Q5BQA0 Q9Y5K2
PDB IDs		1RHF	2BDG 2BDH 2BDI 4K1E 4K8Y 4KEL 4KGA 6KBR 6NVB 6O21 7JOD 7JOE 7JOS 7JOW 7JQK 7JQN 7JQO 7JQV
Enriched GO Terms of Interacting Partners?		Intermediate Filament Keratin Filament Signaling Receptor Binding Protein Tyrosine Kinase Activity Identical Protein Binding Cellular Response To Platelet-derived Growth Factor Stimulus Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Response To Platelet-derived Growth Factor Negative Regulation Of Immune System Process Regulation Of Immune System Process Negative Regulation Of Inflammatory Response To Antigenic Stimulus Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Dendritic Spine Maintenance Vascular Endothelial Growth Factor Receptor Signaling Pathway ErbB-3 Class Receptor Binding Fc-gamma Receptor Signaling Pathway Leukocyte Migration Cellular Response To Oxygen-containing Compound Regulation Of Cell Activation Negative Regulation Of Multicellular Organismal Process Positive Regulation Of Intracellular Signal Transduction Enzyme-linked Receptor Protein Signaling Pathway Substrate Adhesion-dependent Cell Spreading T Cell Costimulation Non-membrane Spanning Protein Tyrosine Kinase Activity RNA Polymerase II CTD Heptapeptide Repeat Phosphatase Activity Regulation Of Innate Immune Response Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Negative Regulation Of Defense Response Cellular Response To Growth Factor Stimulus Peptidyl-tyrosine Phosphorylation Ephrin Receptor Signaling Pathway Regulation Of ERK1 And ERK2 Cascade Regulation Of Immune Response Negative Regulation Of Dendritic Cell Apoptotic Process Fc Receptor Signaling Pathway Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cell-substrate Adhesion Positive Regulation Of Natural Killer Cell Differentiation Cellular Response To Interferon-alpha Regulation Of Intracellular Signal Transduction Positive Regulation Of Establishment Of Protein Localization Positive Regulation Of Immune System Process Regulation Of Lymphocyte Activation Response To Growth Factor Cellular Response To Transforming Growth Factor Beta Stimulus Phospholipase Activator Activity Platelet Alpha Granule Lumen Positive Regulation Of Lymphocyte Activation
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