MST1R and HYAL2

Number of citations: 32 (PubMedID 12676986)
Data Source: HPRD (in vivo)

		MST1R	HYAL2
Name		macrophage stimulating 1 receptor	hyaluronidase 2
Structure			No pdb structure
GO Annotations	Cellular Component	Stress Fiber Vacuole Plasma Membrane Cell Surface Membrane Receptor Complex	Golgi Membrane Cytoplasm Lysosome Endoplasmic Reticulum Cytosol Plasma Membrane Microvillus External Side Of Plasma Membrane Cell Surface Membrane Apical Plasma Membrane Endocytic Vesicle Cytoplasmic Vesicle Membrane Raft Perinuclear Region Of Cytoplasm RNA Polymerase II Transcription Regulator Complex Side Of Membrane
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Macrophage Colony-stimulating Factor Receptor Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Enzyme Binding	Virus Receptor Activity Transcription Coactivator Activity Hyalurononglucosaminidase Activity Protein Binding Hyaluronic Acid Binding Hydrolase Activity Hydrolase Activity, Acting On Glycosyl Bonds Enzyme Binding Receptor Signaling Protein Tyrosine Kinase Inhibitor Activity Receptor Tyrosine Kinase Binding Hyaluronoglucuronidase Activity Transforming Growth Factor Beta Binding
	Biological Process	Immune System Process Phagocytosis Defense Response Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Single Fertilization Nervous System Development Positive Regulation Of Cell Population Proliferation Response To Virus Cell Migration Macrophage Colony-stimulating Factor Signaling Pathway Positive Regulation Of MAP Kinase Activity Innate Immune Response Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction	Response To Reactive Oxygen Species Kidney Development Hematopoietic Progenitor Cell Differentiation Carbohydrate Metabolic Process Glycosaminoglycan Catabolic Process Response To Virus Negative Regulation Of Fibroblast Migration Hyaluronan Catabolic Process Negative Regulation Of Cell Growth Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Urine Volume Monocyte Activation Positive Regulation Of Protein Import Into Nucleus Cellular Response To Fibroblast Growth Factor Stimulus Positive Regulation Of Transcription By RNA Polymerase II Response To Antibiotic Symbiont Entry Into Host Cell Skeletal System Morphogenesis Positive Regulation Of Inflammatory Response Cartilage Development Defense Response To Virus Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Multicellular Organismal-level Iron Ion Homeostasis Renal Water Absorption Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Cellular Response To UV-B Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Signaling by MST1	Hyaluronan metabolism Hyaluronan degradation
Drugs		Crizotinib Fostamatinib	None
GWAS		Adult body size ( 32376654 ) Age at first birth ( 27798627 ) Body mass index ( 26426971 29273807 ) Brain morphology (min-P) ( 32665545 ) Brain morphology (MOSTest) ( 32665545 ) Cortical surface area (MOSTest) ( 32665545 ) Extremely high intelligence ( 29520040 ) Inflammatory bowel disease ( 23128233 ) Refractive error ( 32231278 ) Regular attendance at a gym or sports club ( 29970889 ) Regular attendance at a religious group ( 29970889 ) Sleep duration (short sleep) ( 30846698 ) Subcortical volume (min-P) ( 32665545 ) Subcortical volume (MOSTest) ( 32665545 ) Ulcerative colitis ( 25082827 ) Walking pace ( 33128006 )	Body mass index ( 26426971 ) Brain morphology (min-P) ( 32665545 ) Brain morphology (MOSTest) ( 32665545 ) Cortical surface area (MOSTest) ( 32665545 ) Sleep duration (short sleep) ( 30846698 ) Subcortical volume (min-P) ( 32665545 ) Subcortical volume (MOSTest) ( 32665545 )
Novel Interactors		1 novel interactors: GPX1	None recorded
Interacting Genes		24 interacting genes: AKT1 EPOR ERBB2 GAB1 GJB1 GRB2 HYAL2 JAK2 MST1 PIK3R1 PLCG1 PPP1CA PTPRR RELA SFN SHC1 SRC STUB1 YES1 YWHAB YWHAE YWHAH YWHAQ YWHAZ	16 interacting genes: CYSRT1 FHL3 KRT31 KRT34 KRTAP1-1 KRTAP10-3 KRTAP3-2 KRTAP6-2 KRTAP6-3 MST1R PELI2 SMAD2 SMAD3 SMAD4 TRIM54 WWOX
Entrez ID		4486	8692
HPRD ID		02545	04649
Ensembl ID		ENSG00000164078	ENSG00000068001
Uniprot IDs		B4E058 G9JXB8 H7C074 Q04912	Q12891
PDB IDs		3PLS 4FWW 4QT8 8ZKD	Not available
GO Terms Enriched among Interactors		ERBB Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Intracellular Signal Transduction Regulation Of Defense Response Phosphoserine Residue Binding Neurotrophin TRKA Receptor Binding Negative Regulation Of Immune System Process Signal Transduction Regulation Of Protein Localization To Nucleus Regulation Of Immune Response Enzyme Binding Regulation Of Cell Communication Regulation Of Signaling Regulation Of Signal Transduction Cellular Response To Growth Factor Stimulus Cytosol Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Intracellular Signaling Cassette Response To Growth Factor Regulation Of Apoptotic Process Negative Regulation Of Immune Response Regulation Of Nucleocytoplasmic Transport Regulation Of Cell-cell Adhesion Developmental Process Regulation Of Programmed Cell Death Regulation Of Multicellular Organismal Process Protein Domain Specific Binding Positive Regulation Of Nucleocytoplasmic Transport Regulation Of Cellular Localization ERBB2 Signaling Pathway Transmembrane Transporter Binding Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Protein Transport Regulation Of Immune System Process Regulation Of Intracellular Transport Regulation Of Cell Adhesion Insulin Receptor Signaling Pathway Focal Adhesion Regulation Of Extrinsic Apoptotic Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Negative Regulation Of Inflammatory Response To Antigenic Stimulus Negative Regulation Of Defense Response Cytoplasm Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Innate Immune Response Negative Regulation Of Apoptotic Process Protein Kinase Binding	Intermediate Filament Keratin Filament SMAD Protein Complex Heteromeric SMAD Protein Complex I-SMAD Binding Response To Transforming Growth Factor Beta SMAD Protein Signal Transduction R-SMAD Binding Activin Responsive Factor Complex Paraxial Mesoderm Morphogenesis Activin Receptor Signaling Pathway Endoderm Development Mesoderm Morphogenesis Gastrulation Pericardium Development Trophoblast Cell Migration Epithelial Cell Differentiation Embryonic Pattern Specification Positive Regulation Of Epithelial To Mesenchymal Transition Regulation Of Transforming Growth Factor Beta2 Production Cellular Response To Transforming Growth Factor Beta Stimulus Tissue Morphogenesis Tissue Development Embryonic Foregut Morphogenesis Positive Regulation Of Extracellular Matrix Assembly Nodal Signaling Pathway Co-SMAD Binding Secondary Palate Development Primary MiRNA Processing Transforming Growth Factor Beta Receptor Binding Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Skeletal System Morphogenesis Regulation Of Epithelial To Mesenchymal Transition Extrinsic Apoptotic Signaling Pathway Response To Growth Factor Regulation Of Extracellular Matrix Assembly Response To Glucose Morphogenesis Of An Epithelium Ameboidal-type Cell Migration Osteoblast Differentiation Adrenal Gland Development Response To Monosaccharide Positive Regulation Of Extracellular Matrix Organization Epidermis Development Embryonic Cranial Skeleton Morphogenesis Embryonic Axis Specification Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cytosol Response To Carbohydrate