MST1R and PTPRR

Number of citations: 51 (PubMedID 28065597)
Data Source: BioGRID (two hybrid)

		MST1R	PTPRR
Name		macrophage stimulating 1 receptor	protein tyrosine phosphatase receptor type R
Structure
GO Annotations	Cellular Component	Stress Fiber Vacuole Plasma Membrane Cell Surface Membrane Receptor Complex	Extracellular Region Extracellular Space Cytoplasm Cytosol Plasma Membrane Membrane Cell Junction Perinuclear Region Of Cytoplasm
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Macrophage Colony-stimulating Factor Receptor Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Enzyme Binding	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Protein Binding Hydrolase Activity Protein Kinase Binding
	Biological Process	Immune System Process Phagocytosis Defense Response Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Single Fertilization Nervous System Development Positive Regulation Of Cell Population Proliferation Response To Virus Cell Migration Macrophage Colony-stimulating Factor Signaling Pathway Positive Regulation Of MAP Kinase Activity Innate Immune Response Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction	In Utero Embryonic Development Protein Dephosphorylation Signal Transduction Negative Regulation Of Epithelial Cell Migration ERBB2 Signaling Pathway Negative Regulation Of ERK1 And ERK2 Cascade Regulation Of Homophilic Cell Adhesion
Pathways		Signaling by MST1	None
Drugs		Crizotinib Fostamatinib	None
GWAS		Adult body size ( 32376654 ) Age at first birth ( 27798627 ) Body mass index ( 26426971 29273807 ) Brain morphology (min-P) ( 32665545 ) Brain morphology (MOSTest) ( 32665545 ) Cortical surface area (MOSTest) ( 32665545 ) Extremely high intelligence ( 29520040 ) Inflammatory bowel disease ( 23128233 ) Refractive error ( 32231278 ) Regular attendance at a gym or sports club ( 29970889 ) Regular attendance at a religious group ( 29970889 ) Sleep duration (short sleep) ( 30846698 ) Subcortical volume (min-P) ( 32665545 ) Subcortical volume (MOSTest) ( 32665545 ) Ulcerative colitis ( 25082827 ) Walking pace ( 33128006 )	Apolipoprotein A1 levels ( 32203549 ) Aspartate aminotransferase levels ( 33547301 ) Asthma (adult onset) ( 31036433 ) Asthma (childhood onset) ( 31036433 ) HDL cholesterol levels ( 32203549 ) Influenza A (H1N1) infection ( 26379185 ) Intraocular pressure ( 29785010 ) Mild influenza (H1N1) infection ( 26379185 ) Monobrow ( 27182965 ) Refractive error ( 23396134 32231278 ) Spherical equivalent or myopia (age of diagnosis) ( 29808027 ) Uterine fibroids ( 31649266 )
Novel Interactors		1 novel interactors: GPX1	1 novel interactors: IRS2
Interacting Genes		24 interacting genes: AKT1 EPOR ERBB2 GAB1 GJB1 GRB2 HYAL2 JAK2 MST1 PIK3R1 PLCG1 PPP1CA PTPRR RELA SFN SHC1 SRC STUB1 YES1 YWHAB YWHAE YWHAH YWHAQ YWHAZ	27 interacting genes: AATK CNKSR1 EGFR EPHA2 ERBB2 ERBB3 ERBB4 FGFR2 FGFR4 GABARAPL1 IGF1R INSR KDR LMTK2 MAPK1 MAPK3 MAPK7 MST1R NTRK1 PRKACA PTK7 RET ROR1 ROR2 RYK SNCA TEK
Entrez ID		4486	5801
HPRD ID		02545	04169
Ensembl ID		ENSG00000164078	ENSG00000153233
Uniprot IDs		B4E058 G9JXB8 H7C074 Q04912	B7Z998 Q15256
PDB IDs		3PLS 4FWW 4QT8 8ZKD	2A8B
GO Terms Enriched among Interactors		ERBB Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Intracellular Signal Transduction Regulation Of Defense Response Phosphoserine Residue Binding Neurotrophin TRKA Receptor Binding Negative Regulation Of Immune System Process Signal Transduction Regulation Of Protein Localization To Nucleus Regulation Of Immune Response Enzyme Binding Regulation Of Cell Communication Regulation Of Signaling Regulation Of Signal Transduction Cellular Response To Growth Factor Stimulus Cytosol Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Intracellular Signaling Cassette Response To Growth Factor Regulation Of Apoptotic Process Negative Regulation Of Immune Response Regulation Of Nucleocytoplasmic Transport Regulation Of Cell-cell Adhesion Developmental Process Regulation Of Programmed Cell Death Regulation Of Multicellular Organismal Process Protein Domain Specific Binding Positive Regulation Of Nucleocytoplasmic Transport Regulation Of Cellular Localization ERBB2 Signaling Pathway Transmembrane Transporter Binding Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Protein Transport Regulation Of Immune System Process Regulation Of Intracellular Transport Regulation Of Cell Adhesion Insulin Receptor Signaling Pathway Focal Adhesion Regulation Of Extrinsic Apoptotic Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Negative Regulation Of Inflammatory Response To Antigenic Stimulus Negative Regulation Of Defense Response Cytoplasm Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Innate Immune Response Negative Regulation Of Apoptotic Process Protein Kinase Binding	Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Kinase Activity Protein Tyrosine Kinase Activity Kinase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Receptor Complex Enzyme-linked Receptor Protein Signaling Pathway ATP Binding Nucleotide Binding Transferase Activity Regulation Of MAPK Cascade Cell Surface Receptor Signaling Pathway Positive Regulation Of MAPK Cascade Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Protein Phosphorylation Positive Regulation Of Intracellular Signal Transduction Phosphorylation Peptidyl-tyrosine Phosphorylation Regulation Of Intracellular Signal Transduction Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Response To Growth Factor Positive Regulation Of Signal Transduction Regulation Of Signal Transduction Protein Autophosphorylation ERBB2 Signaling Pathway Positive Regulation Of Cell Population Proliferation Regulation Of Signaling Regulation Of Cell Communication Plasma Membrane Regulation Of ERK1 And ERK2 Cascade Signal Transduction Regulation Of Locomotion Cellular Response To Growth Factor Stimulus Phosphate-containing Compound Metabolic Process Positive Regulation Of ERK1 And ERK2 Cascade Coreceptor Activity Positive Regulation Of Cell Migration Regulation Of Cell Population Proliferation Animal Organ Development Epidermal Growth Factor Receptor Signaling Pathway ERBB2-ERBB3 Signaling Pathway ERBB3 Signaling Pathway Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Cell Motility Positive Regulation Of Locomotion ERBB Signaling Pathway Regulation Of Multicellular Organismal Process Membrane