XRCC3 and RAD51D

Number of citations of the paper that reports this interaction (PubMedID 11744692)
0

Data Source:
HPRD (in vitro, in vivo)

		XRCC3	RAD51D
Description		X-ray repair cross complementing 3	RAD51 paralog D
Image		No pdb structure
GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Nucleoplasm Replication Fork Cytoplasm Mitochondrion Cytosol Rad51C-XRCC3 Complex Perinuclear Region Of Cytoplasm	Chromosome, Telomeric Region Nucleus Nucleoplasm Replication Fork Chromosome Cytoplasm Centrosome Microtubule Organizing Center Cytoskeleton Rad51B-Rad51C-Rad51D-XRCC2 Complex
	Molecular Function	Nucleotide Binding Four-way Junction DNA Binding DNA Binding Protein Binding ATP Binding Crossover Junction DNA Endonuclease Activity ATP-dependent DNA Damage Sensor Activity	Nucleotide Binding Four-way Junction DNA Binding DNA Binding Single-stranded DNA Binding Protein Binding ATP Binding ATP-dependent Activity, Acting On DNA Gamma-tubulin Binding ATP-dependent DNA Damage Sensor Activity
	Biological Process	Telomere Maintenance Via Recombination Double-strand Break Repair Via Homologous Recombination DNA Repair DNA Recombination DNA Damage Response Regulation Of Centrosome Duplication Interstrand Cross-link Repair Double-strand Break Repair Via Synthesis-dependent Strand Annealing Resolution Of Mitotic Recombination Intermediates Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint T-circle Formation Telomeric Loop Disassembly Telomere Maintenance Via Telomere Trimming	Telomere Maintenance Via Recombination Telomere Maintenance Double-strand Break Repair Via Homologous Recombination DNA Repair DNA Recombination DNA Damage Response Reciprocal Meiotic Recombination Interstrand Cross-link Repair DNA Strand Invasion Chromosome Organization Regulation Of Cell Cycle
Pathways		HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange	HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Presynaptic phase of homologous DNA pairing and strand exchange TP53 Regulates Transcription of DNA Repair Genes Defective homologous recombination repair (HRR) due to BRCA1 loss of function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function Impaired BRCA2 binding to PALB2
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 31043756) Body mass index ( 26426971 29273807) Schizophrenia ( 25056061 29483656)
Interacting Genes		22 interacting genes: BAP1 BCAS3 CXCL1 FANCG GREB1 ITIH5 LRATD2 MRC2 OSGIN1 PALB2 PSMC3IP RAD51 RAD51C RAD51D RNF20 SCGB3A1 SERPINB5 SNAI1 SWSAP1 TFF1 ZNHIT3 ZSWIM7	49 interacting genes: AMOTL2 BLM C1orf94 CCDC33 CCNL1 CEP57L1 EFHC2 GEMIN4 HSF2BP IHO1 IKZF1 IKZF3 KATNBL1 KIFC3 KRT15 LIMS1 LNX1 LZTS2 MAPK8IP3 MEOX2 NFKBID PICK1 PNMA1 POLDIP3 PRDM14 PRDM6 RAD51B RAD51C RBM48 REL RHOU RNF138 SORBS3 SPATC1L STX11 SWSAP1 TCF4 TEPSIN TLE5 TRIM14 TTC23 VPS9D1 XRCC2 XRCC3 ZBTB42 ZC2HC1C ZNF343 ZNF774 ZSWIM7
Entrez ID		7517	5892
HPRD ID		07201	04261
Ensembl ID		ENSG00000126215	ENSG00000185379
Uniprot IDs		O43542 Q53XC8	O75771
PDB IDs			2KZ3 8FAZ 8GBJ 8OUY 8OUZ
Enriched GO Terms of Interacting Partners?		Recombinational Repair DNA Strand Invasion Double-strand Break Repair Via Homologous Recombination DNA Recombination Reciprocal Meiotic Recombination Homologous Recombination Double-strand Break Repair Telomere Maintenance Via Recombination ATP-dependent DNA Damage Sensor Activity Shu Complex Mitotic Recombination DNA Metabolic Process DNA Repair Rad51B-Rad51C-Rad51D-XRCC2 Complex DNA Recombinase Assembly Interstrand Cross-link Repair DNA Damage Response Meiosis I Cell Cycle Process Four-way Junction DNA Binding Telomere Maintenance Single-stranded DNA Binding Nucleic Acid Metabolic Process Telomere Organization Replication Fork ATP-dependent Activity, Acting On DNA Reproductive Process Growth Factor Activity Response To Glucoside Chromosome Organization Meiosis I Female Meiosis Sister Chromatid Cohesion Nucleate Erythrocyte Differentiation Thrombocyte Differentiation Meiotic Joint Molecule Formation DNA Recombinase Auxiliary Factor Complex Recombinase Activator Activity Meiotic Strand Invasion Involved In Reciprocal Meiotic Recombination Histone H2B C-terminal K Residue Ubiquitin Ligase Activity Condensed Nuclear Chromosome Mitotic Recombination-dependent Replication Fork Processing DNA Strand Exchange Activity Chromosome Organization Involved In Meiotic Cell Cycle Presynaptic Intermediate Filament Cytoskeleton Rad51C-XRCC3 Complex Meiotic DNA Recombinase Assembly Mesoderm Development Negative Regulation Of Cell Differentiation Involved In Embryonic Placenta Development Macrophage Homeostasis Cellular Response To Stress Nucleobase-containing Compound Metabolic Process	Four-way Junction DNA Binding Recombinational Repair Double-strand Break Repair Via Homologous Recombination Double-strand Break Repair Replication Fork DNA Recombination Rad51B-Rad51C-Rad51D-XRCC2 Complex ATP-dependent DNA Damage Sensor Activity Protein Binding Rad51C-XRCC3 Complex Shu Complex DNA Repair DNA Metabolic Process DNA Binding Resolution Of DNA Recombination Intermediates Single-stranded DNA Binding Crossover Junction DNA Endonuclease Activity DNA Damage Response Telomeric Loop Disassembly T-circle Formation Telomere Maintenance Via Recombination Zinc Ion Binding Somite Development Meiosis I Cell Cycle Process
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