RAD51D and SWSAP1

Number of citations of the paper that reports this interaction (PubMedID 21965664)
23

Data Source:
BioGRID (affinity chromatography technology, pull down)

		RAD51D	SWSAP1
Description		RAD51 paralog D	SWIM-type zinc finger 7 associated protein 1
Image			No pdb structure
GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Nucleoplasm Replication Fork Chromosome Cytoplasm Centrosome Microtubule Organizing Center Cytoskeleton Rad51B-Rad51C-Rad51D-XRCC2 Complex	Nucleus Shu Complex
	Molecular Function	Nucleotide Binding Four-way Junction DNA Binding DNA Binding Single-stranded DNA Binding Protein Binding ATP Binding ATP-dependent Activity, Acting On DNA Gamma-tubulin Binding ATP-dependent DNA Damage Sensor Activity	DNA Binding Single-stranded DNA Binding Protein Binding ATP Hydrolysis Activity
	Biological Process	Telomere Maintenance Via Recombination Telomere Maintenance Double-strand Break Repair Via Homologous Recombination DNA Repair DNA Recombination DNA Damage Response Reciprocal Meiotic Recombination Interstrand Cross-link Repair DNA Strand Invasion Chromosome Organization Regulation Of Cell Cycle	Double-strand Break Repair Via Homologous Recombination DNA Repair DNA Recombination DNA Damage Response Protein Stabilization
Pathways		HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Presynaptic phase of homologous DNA pairing and strand exchange TP53 Regulates Transcription of DNA Repair Genes Defective homologous recombination repair (HRR) due to BRCA1 loss of function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function Impaired BRCA2 binding to PALB2
Drugs
Diseases
GWAS			Coronary artery disease ( 29212778)
Interacting Genes		49 interacting genes: AMOTL2 BLM C1orf94 CCDC33 CCNL1 CEP57L1 EFHC2 GEMIN4 HSF2BP IHO1 IKZF1 IKZF3 KATNBL1 KIFC3 KRT15 LIMS1 LNX1 LZTS2 MAPK8IP3 MEOX2 NFKBID PICK1 PNMA1 POLDIP3 PRDM14 PRDM6 RAD51B RAD51C RBM48 REL RHOU RNF138 SORBS3 SPATC1L STX11 SWSAP1 TCF4 TEPSIN TLE5 TRIM14 TTC23 VPS9D1 XRCC2 XRCC3 ZBTB42 ZC2HC1C ZNF343 ZNF774 ZSWIM7	8 interacting genes: A2M EPM2AIP1 RAD51 RAD51B RAD51C RAD51D SPG21 XRCC3
Entrez ID		5892	126074
HPRD ID		04261	08179
Ensembl ID		ENSG00000185379	ENSG00000173928
Uniprot IDs		O75771	A0A6I8PRB2 Q6NVH7
PDB IDs		2KZ3 8FAZ 8GBJ 8OUY 8OUZ
Enriched GO Terms of Interacting Partners?		Four-way Junction DNA Binding Recombinational Repair Double-strand Break Repair Via Homologous Recombination Double-strand Break Repair Replication Fork DNA Recombination Rad51B-Rad51C-Rad51D-XRCC2 Complex ATP-dependent DNA Damage Sensor Activity Protein Binding Rad51C-XRCC3 Complex Shu Complex DNA Repair DNA Metabolic Process DNA Binding Resolution Of DNA Recombination Intermediates Single-stranded DNA Binding Crossover Junction DNA Endonuclease Activity DNA Damage Response Telomeric Loop Disassembly T-circle Formation Telomere Maintenance Via Recombination Zinc Ion Binding Somite Development Meiosis I Cell Cycle Process	ATP-dependent DNA Damage Sensor Activity Telomere Maintenance Via Recombination Four-way Junction DNA Binding Mitotic Recombination Rad51B-Rad51C-Rad51D-XRCC2 Complex Reciprocal Meiotic Recombination Replication Fork Double-strand Break Repair Via Homologous Recombination Homologous Recombination Recombinational Repair Double-strand Break Repair DNA Recombination Telomere Maintenance Rad51C-XRCC3 Complex Telomere Organization ATP-dependent Activity, Acting On DNA Interstrand Cross-link Repair DNA Repair DNA Strand Invasion DNA Recombinase Assembly Crossover Junction DNA Endonuclease Activity DNA Metabolic Process DNA Damage Response Chromosome Organization Single-stranded DNA Binding Regulation Of Cell Cycle Phase Transition Regulation Of Cell Cycle Chromosome, Telomeric Region Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Cell Cycle G2/M Phase Transition Meiosis I ATP Binding Positive Regulation Of Cell Cycle Process Regulation Of Cell Cycle Process Cellular Response To Stress Positive Regulation Of Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition Nucleotide Binding Meiosis I Cell Cycle Process Response To Glucoside Female Meiosis Sister Chromatid Cohesion Meiotic Nuclear Division Negative Regulation Of Complement Activation, Lectin Pathway Mitotic Recombination-dependent Replication Fork Processing Nuclear Division Macromolecule Metabolic Process DNA Strand Exchange Activity Presynaptic Intermediate Filament Cytoskeleton Nucleic Acid Metabolic Process Positive Regulation Of Mitotic Cell Cycle Phase Transition
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